ID O25223_HELPY Unreviewed; 545 AA.
AC O25223;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=HP_0478 {ECO:0000313|EMBL:AAD07545.1};
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962 {ECO:0000313|EMBL:AAD07545.1, ECO:0000313|Proteomes:UP000000429};
RN [1] {ECO:0000313|EMBL:AAD07545.1, ECO:0000313|Proteomes:UP000000429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695 {ECO:0000313|Proteomes:UP000000429};
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.P., Gill S., Dougherty B.A.,
RA Nelson K., Quackenbush J., Zhou L., Kirkness E.F., Peterson S., Loftus B.,
RA Richardson D., Dodson R., Khalak H.G., Glodek A., McKenney K.,
RA Fitzegerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D.,
RA Utterback T.R., Peterson J.D., Kelley J.M., Karp P.D., Smith H.O.,
RA Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; AE000511; AAD07545.1; -; Genomic_DNA.
DR PIR; F64579; F64579.
DR RefSeq; NP_207276.1; NC_000915.1.
DR RefSeq; WP_001139725.1; NC_018939.1.
DR AlphaFoldDB; O25223; -.
DR STRING; 85962.HP_0478; -.
DR REBASE; 3066; M.HpyAVII.
DR REBASE; 56852; M.Hpy26695II.
DR PaxDb; 85962-C694_02450; -.
DR EnsemblBacteria; AAD07545; AAD07545; HP_0478.
DR KEGG; hpy:HP_0478; -.
DR PATRIC; fig|85962.47.peg.513; -.
DR eggNOG; COG0827; Bacteria.
DR InParanoid; O25223; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.90.220.10; Adenine-n6-DNA-methyltransferase Taqi, Chain A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR023135; N6_DNA_MeTrfase_TaqI_C.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR025931; TaqI_C.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF12950; TaqI_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AAD07545.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000429};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 93..318
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 388..501
FT /note="TaqI-like C-terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF12950"
SQ SEQUENCE 545 AA; 63177 MW; 7752822ABB9C671E CRC64;
MPSNALLIEE ITHLINVSHS SVHNWIKTNL LEKLEIDHKI YVKTSSFLDF CRNHLGKNKL
NKYANKSLKG VHNHQELILK YLEILENSSD LEKLGSYYEE ELSNATRNLE GIYYTPNRIV
EQLFTLPKDF DVSQAIFCDP AVGSGNFIMH ALKLGFKVEN IYGYDTDAFA VALTKKRIKE
RYHLDCLNIV QKDFLNLKHT PQFDCIFTNP PWGKKYNQNQ KENFKQQFNL SQSLDSASLF
FIASLNCLKE NAHLGLLLPE SCLNIDAFKK MREMALKFHI RSLIDFDKPF KNLMTKAVGL
ALKKTPNKDQ KISCFYQNSK FKRSPSSFFN NPKKIFNIHC SSKENKILDH LFSLPHMTLK
NNAHFALGIV TGNNKEKLHP KQEKNTIPIF RGSDILKDGL KAPSQFINAG LKDCQQVAPL
SLYQAREKIV YKFISSKLVF FYDNKQRLFL NSANMFVLKE NFPINAHALK ELLNSDLMQF
IFESLFKTHK ILRKDLECLP LFVQFINDNF DEKFYLKNLG IEKKDPKHFT IRKNHACCLS
FGFRG
//
