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Database: UniProt
Entry: O25496_HELPY
LinkDB: O25496_HELPY
Original site: O25496_HELPY 
ID   O25496_HELPY            Unreviewed;       553 AA.
AC   O25496;
DT   01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JAN-1998, sequence version 1.
DT   24-JAN-2024, entry version 133.
DE   SubName: Full=Osmoprotection protein (ProWX) {ECO:0000313|EMBL:AAD07866.1};
GN   OrderedLocusNames=HP_0818 {ECO:0000313|EMBL:AAD07866.1};
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962 {ECO:0000313|EMBL:AAD07866.1, ECO:0000313|Proteomes:UP000000429};
RN   [1] {ECO:0000313|EMBL:AAD07866.1, ECO:0000313|Proteomes:UP000000429}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695 {ECO:0000313|Proteomes:UP000000429};
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.P., Gill S., Dougherty B.A.,
RA   Nelson K., Quackenbush J., Zhou L., Kirkness E.F., Peterson S., Loftus B.,
RA   Richardson D., Dodson R., Khalak H.G., Glodek A., McKenney K.,
RA   Fitzegerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D.,
RA   Utterback T.R., Peterson J.D., Kelley J.M., Karp P.D., Smith H.O.,
RA   Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363032};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363032}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. {ECO:0000256|RuleBase:RU363032}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the OsmX family.
CC       {ECO:0000256|ARBA:ARBA00035642}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the binding-protein-
CC       dependent transport system permease family.
CC       {ECO:0000256|ARBA:ARBA00035652}.
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DR   EMBL; AE000511; AAD07866.1; -; Genomic_DNA.
DR   PIR; B64622; B64622.
DR   RefSeq; NP_207611.1; NC_000915.1.
DR   RefSeq; WP_000901317.1; NC_018939.1.
DR   AlphaFoldDB; O25496; -.
DR   SMR; O25496; -.
DR   DIP; DIP-3623N; -.
DR   IntAct; O25496; 2.
DR   MINT; O25496; -.
DR   STRING; 85962.HP_0818; -.
DR   PaxDb; 85962-C694_04190; -.
DR   EnsemblBacteria; AAD07866; AAD07866; HP_0818.
DR   KEGG; hpy:HP_0818; -.
DR   PATRIC; fig|85962.47.peg.871; -.
DR   eggNOG; COG1174; Bacteria.
DR   eggNOG; COG1732; Bacteria.
DR   InParanoid; O25496; -.
DR   OMA; FRSLHEM; -.
DR   OrthoDB; 9781705at2; -.
DR   PhylomeDB; O25496; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0031460; P:glycine betaine transport; IBA:GO_Central.
DR   GO; GO:0006950; P:response to stress; IEA:UniProt.
DR   CDD; cd13612; PBP2_ProWX; 1.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; MetI-like; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR   InterPro; IPR007210; ABC_Gly_betaine_transp_sub-bd.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   PANTHER; PTHR30177; GLYCINE BETAINE/L-PROLINE TRANSPORT SYSTEM PERMEASE PROTEIN PROW; 1.
DR   PANTHER; PTHR30177:SF4; OSMOPROTECTANT IMPORT PERMEASE PROTEIN OSMW; 1.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   Pfam; PF04069; OpuAC; 1.
DR   SUPFAM; SSF161098; MetI-like; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363032};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000429};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363032};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363032}; Transport {ECO:0000256|RuleBase:RU363032}.
FT   TRANSMEM        57..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363032"
FT   TRANSMEM        91..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363032"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363032"
FT   TRANSMEM        169..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363032"
FT   TRANSMEM        217..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363032"
FT   TRANSMEM        261..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363032"
FT   DOMAIN          57..236
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50928"
SQ   SEQUENCE   553 AA;  62471 MW;  E39BCB1D42E7E744 CRC64;
     MLGMGVFKQL IKGLYEWLLH SIDVATQHLV AIVLKISVVK YLIKEFHDRF IYFIDLIAQH
     FIIVALSSFL VLVFGVLIGV LVFYNSKARA FLLPVVNFLY TIPSLALFAL FIPVIGVGLK
     NALLVLVLYG LLPIVHSTYN ALKEVREEVI KAAIGLGCNP KELFFKVRFL LAIPQILAGL
     RIAVVMLVAM AGIGALIGAG GLGQAIFRGL NTQNTTLLVA GSLIIALFSV LADKFVSVFQ
     HENALQRLFS QNATKKQKRR VYTNLAVFLF LLLASALWLI PRNAIEEKPL VVATKPSSEQ
     YILGEILSLL LEKHHIPIKR AFGIGGGTMN IHPALIRGDF DLYVEYTGTA WVNTLKNPLT
     QKVDFETIKK RYEKEFNLLW VGLLGFNNTY SLAISKEDAQ KYAIETFSDL AFHSPNFDFG
     AEFDFFERED AFKGLVKAYR FHFRSLHEMD INLRYKSFES HKINALDVFT TDAQIKELDL
     KVLKDDKGFF PNYQAGIVIR KEIVKKYPEA LEILEKLDSK ISDEKMQDLN YQVEVLKKSP
     QIVAKDFLER LGL
//
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