ID O25496_HELPY Unreviewed; 553 AA.
AC O25496;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 24-JAN-2024, entry version 133.
DE SubName: Full=Osmoprotection protein (ProWX) {ECO:0000313|EMBL:AAD07866.1};
GN OrderedLocusNames=HP_0818 {ECO:0000313|EMBL:AAD07866.1};
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962 {ECO:0000313|EMBL:AAD07866.1, ECO:0000313|Proteomes:UP000000429};
RN [1] {ECO:0000313|EMBL:AAD07866.1, ECO:0000313|Proteomes:UP000000429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695 {ECO:0000313|Proteomes:UP000000429};
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.P., Gill S., Dougherty B.A.,
RA Nelson K., Quackenbush J., Zhou L., Kirkness E.F., Peterson S., Loftus B.,
RA Richardson D., Dodson R., Khalak H.G., Glodek A., McKenney K.,
RA Fitzegerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D.,
RA Utterback T.R., Peterson J.D., Kelley J.M., Karp P.D., Smith H.O.,
RA Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363032};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363032}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000256|RuleBase:RU363032}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the OsmX family.
CC {ECO:0000256|ARBA:ARBA00035642}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the binding-protein-
CC dependent transport system permease family.
CC {ECO:0000256|ARBA:ARBA00035652}.
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DR EMBL; AE000511; AAD07866.1; -; Genomic_DNA.
DR PIR; B64622; B64622.
DR RefSeq; NP_207611.1; NC_000915.1.
DR RefSeq; WP_000901317.1; NC_018939.1.
DR AlphaFoldDB; O25496; -.
DR SMR; O25496; -.
DR DIP; DIP-3623N; -.
DR IntAct; O25496; 2.
DR MINT; O25496; -.
DR STRING; 85962.HP_0818; -.
DR PaxDb; 85962-C694_04190; -.
DR EnsemblBacteria; AAD07866; AAD07866; HP_0818.
DR KEGG; hpy:HP_0818; -.
DR PATRIC; fig|85962.47.peg.871; -.
DR eggNOG; COG1174; Bacteria.
DR eggNOG; COG1732; Bacteria.
DR InParanoid; O25496; -.
DR OMA; FRSLHEM; -.
DR OrthoDB; 9781705at2; -.
DR PhylomeDB; O25496; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0031460; P:glycine betaine transport; IBA:GO_Central.
DR GO; GO:0006950; P:response to stress; IEA:UniProt.
DR CDD; cd13612; PBP2_ProWX; 1.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; MetI-like; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR007210; ABC_Gly_betaine_transp_sub-bd.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR PANTHER; PTHR30177; GLYCINE BETAINE/L-PROLINE TRANSPORT SYSTEM PERMEASE PROTEIN PROW; 1.
DR PANTHER; PTHR30177:SF4; OSMOPROTECTANT IMPORT PERMEASE PROTEIN OSMW; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR Pfam; PF04069; OpuAC; 1.
DR SUPFAM; SSF161098; MetI-like; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363032};
KW Reference proteome {ECO:0000313|Proteomes:UP000000429};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363032};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363032}; Transport {ECO:0000256|RuleBase:RU363032}.
FT TRANSMEM 57..84
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 91..116
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 169..197
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 217..240
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 261..280
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT DOMAIN 57..236
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50928"
SQ SEQUENCE 553 AA; 62471 MW; E39BCB1D42E7E744 CRC64;
MLGMGVFKQL IKGLYEWLLH SIDVATQHLV AIVLKISVVK YLIKEFHDRF IYFIDLIAQH
FIIVALSSFL VLVFGVLIGV LVFYNSKARA FLLPVVNFLY TIPSLALFAL FIPVIGVGLK
NALLVLVLYG LLPIVHSTYN ALKEVREEVI KAAIGLGCNP KELFFKVRFL LAIPQILAGL
RIAVVMLVAM AGIGALIGAG GLGQAIFRGL NTQNTTLLVA GSLIIALFSV LADKFVSVFQ
HENALQRLFS QNATKKQKRR VYTNLAVFLF LLLASALWLI PRNAIEEKPL VVATKPSSEQ
YILGEILSLL LEKHHIPIKR AFGIGGGTMN IHPALIRGDF DLYVEYTGTA WVNTLKNPLT
QKVDFETIKK RYEKEFNLLW VGLLGFNNTY SLAISKEDAQ KYAIETFSDL AFHSPNFDFG
AEFDFFERED AFKGLVKAYR FHFRSLHEMD INLRYKSFES HKINALDVFT TDAQIKELDL
KVLKDDKGFF PNYQAGIVIR KEIVKKYPEA LEILEKLDSK ISDEKMQDLN YQVEVLKKSP
QIVAKDFLER LGL
//