ID O25907_HELPY Unreviewed; 359 AA.
AC O25907;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE RecName: Full=Methyltransferase {ECO:0000256|RuleBase:RU362026};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU362026};
GN OrderedLocusNames=HP_1352 {ECO:0000313|EMBL:AAD08395.1};
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962 {ECO:0000313|EMBL:AAD08395.1, ECO:0000313|Proteomes:UP000000429};
RN [1] {ECO:0000313|EMBL:AAD08395.1, ECO:0000313|Proteomes:UP000000429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695 {ECO:0000313|Proteomes:UP000000429};
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.P., Gill S., Dougherty B.A.,
RA Nelson K., Quackenbush J., Zhou L., Kirkness E.F., Peterson S., Loftus B.,
RA Richardson D., Dodson R., Khalak H.G., Glodek A., McKenney K.,
RA Fitzegerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D.,
RA Utterback T.R., Peterson J.D., Kelley J.M., Karp P.D., Smith H.O.,
RA Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594, ECO:0000256|RuleBase:RU362026}.
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DR EMBL; AE000511; AAD08395.1; -; Genomic_DNA.
DR PIR; H64688; H64688.
DR RefSeq; NP_208144.1; NC_000915.1.
DR RefSeq; WP_000346779.1; NC_018939.1.
DR AlphaFoldDB; O25907; -.
DR STRING; 85962.HP_1352; -.
DR REBASE; 3070; M.HpyAIV.
DR REBASE; 56831; M.Hpy26695VII.
DR PaxDb; 85962-C694_06975; -.
DR EnsemblBacteria; AAD08395; AAD08395; HP_1352.
DR KEGG; hpy:HP_1352; -.
DR PATRIC; fig|85962.47.peg.1447; -.
DR eggNOG; COG2189; Bacteria.
DR InParanoid; O25907; -.
DR OrthoDB; 9800801at2; -.
DR PhylomeDB; O25907; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IBA:GO_Central.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR001091; RM_Methyltransferase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR13370:SF32; DNA ADENINE METHYLTRANSFERASE YHDJ; 1.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR PRINTS; PR00508; S21N4MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AAD08395.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000429};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 28..249
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
SQ SEQUENCE 359 AA; 41887 MW; 88A9C4D7CD82973D CRC64;
MDFLKENLNT IIEGDCLEKL KDFPNRSVDF IFADPPYFMQ TEGELKRFEG TKFQGVEDYW
DKFGSFKEYD AFCLGWLKEC QRILKDNGSI CVIGSFQNIF RIGFHLQNLG FWILNDIIWH
KSNPVPNFAG KRLCNAHETL IWCAKHKNSK VAFNYKTMKY LNNDKQEKSV WQIPICMGNE
RLKDAQGKKV HSTQKPEALL KKIILSATKP KDIILDPFFG TGTTGAVAKS MNRYFIGIEK
DSFYIKEAAK RLNNTRDKSD FITNLDLETK PPKIPMSLLI SKQLLKIGDF LYSPNKEKIC
QVLENGQVRD NENYETSIHK MSAKYLNKTN HNGWKFFYAY YQNQFLLLDE LRYICQKDS
//
