ID O27066_METTH Unreviewed; 365 AA.
AC O27066;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=Sensory transduction histidine kinase {ECO:0000313|EMBL:AAB85482.1};
GN OrderedLocusNames=MTH_985 {ECO:0000313|EMBL:AAB85482.1};
OS Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=187420 {ECO:0000313|EMBL:AAB85482.1, ECO:0000313|Proteomes:UP000005223};
RN [1] {ECO:0000313|EMBL:AAB85482.1, ECO:0000313|Proteomes:UP000005223}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H
RC {ECO:0000313|Proteomes:UP000005223};
RX PubMed=9371463;
RA Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA Pietrovski S., Church G.M., Daniels C.J., Mao J.-i., Rice P., Nolling J.,
RA Reeve J.N.;
RT "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT functional analysis and comparative genomics.";
RL J. Bacteriol. 179:7135-7155(1997).
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DR EMBL; AE000666; AAB85482.1; -; Genomic_DNA.
DR PIR; H69231; H69231.
DR RefSeq; WP_010876616.1; NC_000916.1.
DR AlphaFoldDB; O27066; -.
DR STRING; 187420.MTH_985; -.
DR PaxDb; 187420-MTH_985; -.
DR EnsemblBacteria; AAB85482; AAB85482; MTH_985.
DR GeneID; 77401518; -.
DR KEGG; mth:MTH_985; -.
DR PATRIC; fig|187420.15.peg.968; -.
DR HOGENOM; CLU_000445_114_57_2; -.
DR InParanoid; O27066; -.
DR Proteomes; UP000005223; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR011495; Sig_transdc_His_kin_sub2_dim/P.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR PANTHER; PTHR43065:SF23; SENSOR HISTIDINE KINASE PDTAS-RELATED; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07568; HisKA_2; 1.
DR Pfam; PF00989; PAS; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:AAB85482.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005223};
KW Transferase {ECO:0000313|EMBL:AAB85482.1}.
FT DOMAIN 35..100
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 106..156
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 167..360
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 365 AA; 41615 MW; 50C56FE519290714 CRC64;
MSDRDWETLR EKIIGFGEKS VRKSYYPRLQ ESMAELERFR KLLDCADDAI FLVKIPGGEL
VDANRSACVM LGYSTRDIPG HMVYDLLPGE LHNVFRGILE GDEDRVTMDG RLLKRDGDEV
PVEIKVNILD FKGDRYAVLV ARDISERLRM ESELMKSLRE NEVLLSEIHH RVKNNLQIIS
SLLSLQSHGI DDPSCRSLLS ESQDRIRSMA LIHEQLYRSG DFSSIEFSSY ASRLLKNLKR
SYAPGKNIEL SLDTENLKLS LETSIPLGLM LSELVTNALK HAFKGRDSGN IIVKFKKDGD
YCVLEVRDDG VGFNEEKIRN STSLGFRLVE ILTEQLDGSL TYSGENGGLF RIRFREPLYK
DRLTN
//
