ID O2AG1_HUMAN Reviewed; 316 AA.
AC Q9H205; B9EKV7; Q6IFG7; Q96R26;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2001, sequence version 2.
DT 24-JAN-2024, entry version 173.
DE RecName: Full=Olfactory receptor 2AG1;
DE AltName: Full=HT3;
DE AltName: Full=Olfactory receptor 2AG3;
DE AltName: Full=Olfactory receptor OR11-79;
GN Name=OR2AG1; Synonyms=OR2AG3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-316, AND VARIANTS LEU-187 AND
RP GLY-299.
RX PubMed=11416212; DOI=10.1073/pnas.131215398;
RA Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L.,
RA Evans G., Axel R., Hood L., Trask B.J.;
RT "Genomic analysis of orthologous mouse and human olfactory receptor loci.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001).
RN [6]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [7]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC Q9H205; O75970: MPDZ; NbExp=8; IntAct=EBI-7590304, EBI-821405;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2AG1";
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DR EMBL; AB065823; BAC06042.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68677.1; -; Genomic_DNA.
DR EMBL; BC151143; AAI51144.1; -; mRNA.
DR EMBL; AF399618; AAK95103.1; -; Genomic_DNA.
DR EMBL; AF321237; AAG45209.1; -; Genomic_DNA.
DR EMBL; BK004295; DAA04693.1; -; Genomic_DNA.
DR CCDS; CCDS31414.1; -.
DR RefSeq; NP_001004489.1; NM_001004489.2.
DR AlphaFoldDB; Q9H205; -.
DR SMR; Q9H205; -.
DR IntAct; Q9H205; 1.
DR MINT; Q9H205; -.
DR STRING; 9606.ENSP00000493074; -.
DR TCDB; 9.A.14.8.2; the g-protein-coupled receptor (gpcr) family.
DR GlyCosmos; Q9H205; 2 sites, No reported glycans.
DR GlyGen; Q9H205; 2 sites.
DR BioMuta; OR2AG1; -.
DR DMDM; 14423804; -.
DR MassIVE; Q9H205; -.
DR PaxDb; 9606-ENSP00000485326; -.
DR PeptideAtlas; Q9H205; -.
DR ProteomicsDB; 80466; -.
DR Antibodypedia; 78188; 25 antibodies from 10 providers.
DR DNASU; 144125; -.
DR Ensembl; ENST00000641258.1; ENSP00000493074.1; ENSG00000279486.6.
DR GeneID; 144125; -.
DR KEGG; hsa:144125; -.
DR MANE-Select; ENST00000641258.1; ENSP00000493074.1; NM_001004489.3; NP_001004489.1.
DR UCSC; uc001mer.2; human.
DR AGR; HGNC:15142; -.
DR CTD; 144125; -.
DR DisGeNET; 144125; -.
DR GeneCards; OR2AG1; -.
DR HGNC; HGNC:15142; OR2AG1.
DR HPA; ENSG00000279486; Not detected.
DR neXtProt; NX_Q9H205; -.
DR OpenTargets; ENSG00000279486; -.
DR PharmGKB; PA32126; -.
DR VEuPathDB; HostDB:ENSG00000279486; -.
DR eggNOG; ENOG502SIEP; Eukaryota.
DR GeneTree; ENSGT01090000259995; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q9H205; -.
DR OMA; YELFVYV; -.
DR OrthoDB; 3784606at2759; -.
DR PhylomeDB; Q9H205; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q9H205; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q9H205; -.
DR BioGRID-ORCS; 144125; 4 hits in 734 CRISPR screens.
DR GeneWiki; OR2AG1; -.
DR GenomeRNAi; 144125; -.
DR Pharos; Q9H205; Tdark.
DR PRO; PR:Q9H205; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H205; Protein.
DR Bgee; ENSG00000279486; Expressed in bone marrow cell and 5 other cell types or tissues.
DR ExpressionAtlas; Q9H205; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR CDD; cd15421; 7tmA_OR2T-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR26453:SF183; OLFACTORY RECEPTOR 2AG1; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 2AG1"
FT /id="PRO_0000150472"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 187
FT /note="V -> L (in dbSNP:rs2659880)"
FT /evidence="ECO:0000269|PubMed:11416212"
FT /id="VAR_053140"
FT VARIANT 299
FT /note="R -> G (in dbSNP:rs2659879)"
FT /evidence="ECO:0000269|PubMed:11416212"
FT /id="VAR_059985"
FT VARIANT 299
FT /note="R -> W (in dbSNP:rs2659879)"
FT /id="VAR_059986"
SQ SEQUENCE 316 AA; 35270 MW; 6885161BD606C0AE CRC64;
MELWNFTLGS GFILVGILND SGSPELLCAT ITILYLLALI SNGLLLLAIT MEARLHMPMY
LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ MFLALTMGGA EDLLLAFMAY
DRYVAICHPL TYMTLMSSRA CWLMVATSWI LASLSALIYT VYTMHYPFCR AQEIRHLLCE
IPHLLKVACA DTSRYELMVY VMGVTFLIPS LAAILASYTQ ILLTVLHMPS NEGRKKALVT
CSSHLTVVGM FYGAATFMYV LPSSFHSTRQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA
LRRVLGKYML PAHSTL
//
