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Database: UniProt
Entry: O33116
LinkDB: O33116
Original site: O33116 
ID   SERA_MYCLE              Reviewed;         528 AA.
AC   O33116;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-APR-2014, entry version 107.
DE   RecName: Full=D-3-phosphoglycerate dehydrogenase;
DE            Short=PGDH;
DE            EC=1.1.1.95;
GN   Name=serA; OrderedLocusNames=ML1692; ORFNames=MLCB637.25;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- CATALYTIC ACTIVITY: 3-phospho-D-glycerate + NAD(+) = 3-
CC       phosphonooxypyruvate + NADH.
CC   -!- CATALYTIC ACTIVITY: 2-hydroxyglutarate + NAD(+) = 2-oxoglutarate +
CC       NADH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine
CC       from 3-phospho-D-glycerate: step 1/3.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family.
CC   -!- SIMILARITY: Contains 1 ACT domain.
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DR   EMBL; Z99263; CAB16440.1; -; Genomic_DNA.
DR   EMBL; AL583923; CAC30645.1; -; Genomic_DNA.
DR   PIR; T45418; T45418.
DR   RefSeq; NP_302163.1; NC_002677.1.
DR   ProteinModelPortal; O33116; -.
DR   SMR; O33116; 3-528.
DR   STRING; 272631.ML1692; -.
DR   EnsemblBacteria; CAC30645; CAC30645; CAC30645.
DR   GeneID; 910062; -.
DR   KEGG; mle:ML1692; -.
DR   PATRIC; 18056520; VBIMycLep78757_3189.
DR   Leproma; ML1692; -.
DR   eggNOG; COG0111; -.
DR   HOGENOM; HOG000136693; -.
DR   KO; K00058; -.
DR   OMA; LMIRSGT; -.
DR   OrthoDB; EOG6VXFC3; -.
DR   ProtClustDB; PRK13581; -.
DR   UniPathway; UPA00135; UER00196.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0004617; F:phosphoglycerate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006564; P:L-serine biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.720; -; 2.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR006140; D-isomer_2_OHA_DH_NAD-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR006236; PGDH_1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   Pfam; PF01842; ACT; 1.
DR   TIGRFAMs; TIGR01327; PGDH; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; NAD; Oxidoreductase;
KW   Serine biosynthesis.
FT   CHAIN         1    528       D-3-phosphoglycerate dehydrogenase.
FT                                /FTId=PRO_0000076004.
FT   DOMAIN      455    528       ACT.
FT   NP_BIND     151    152       NAD (By similarity).
FT   NP_BIND     230    232       NAD (By similarity).
FT   NP_BIND     279    282       NAD (By similarity).
FT   ACT_SITE    232    232       By similarity.
FT   ACT_SITE    261    261       By similarity.
FT   ACT_SITE    279    279       Proton donor (By similarity).
FT   BINDING     171    171       NAD (By similarity).
FT   BINDING     256    256       NAD (By similarity).
SQ   SEQUENCE   528 AA;  54469 MW;  1A6DC60F9FB71222 CRC64;
     MDLPVVLIAD KLAQSTVAAL GDQVEVRWVD GPDRTKLLAA VPEADALLVR SATTVDAEVL
     AAAPKLKIVA RAGVGLDNVD VDAATARGVL VVNAPTSNIH SAAEHALALL LAASRQIAEA
     DASLRAHIWK RSSFSGTEIF GKTVGVVGLG RIGQLVAARI AAFGAHVIAY DPYVAPARAA
     QLGIELMSFD DLLARADFIS VHLPKTPETA GLIDKEALAK TKPGVIIVNA ARGGLVDEVA
     LADAVRSGHV RAAGLDVFAT EPCTDSPLFE LSQVVVTPHL GASTAEAQDR AGTDVAESVR
     LALAGEFVPD AVNVDGGVVN EEVAPWLDLV CKLGVLVAAL SDELPASLSV HVRGELASED
     VEILRLSALR GLFSTVIEDA VTFVNAPALA AERGVSAEIT TGSESPNHRS VVDVRAVASD
     GSVVNIAGTL SGPQLVQKIV QVNGRNFDLR AQGMNLVIRY VDQPGALGKI GTLLGAAGVN
     IQAAQLSEDT EGPGATILLR LDQDVPGDVR SAIVAAVSAN KLEVVNLS
//
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