ID FAN_MOUSE Reviewed; 920 AA.
AC O35242; A2AKK1;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 2.
DT 27-MAR-2024, entry version 163.
DE RecName: Full=Protein FAN;
DE AltName: Full=Factor associated with neutral sphingomyelinase activation;
DE Short=Factor associated with N-SMase activation;
GN Name=Nsmaf; Synonyms=Fan;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=10228161; DOI=10.1093/emboj/18.9.2472;
RA Kreder D., Krut O., Adam-Klages S., Wiegmann K., Scherer G., Plitz T.,
RA Jensen J.M., Proksch E., Steinmann J., Pfeffer K., Kroenke M.;
RT "Impaired neutral sphingomyelinase activation and cutaneous barrier repair
RT in FAN-deficient mice.";
RL EMBO J. 18:2472-2479(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral
CC sphingomyelinase (N-SMASE). Specifically binds to the N-smase
CC activation domain of TNF-R55. May regulate ceramide production by N-
CC SMASE.
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DR EMBL; AF013632; AAB65394.1; -; mRNA.
DR EMBL; AL772306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX510318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466538; EDL05686.1; -; Genomic_DNA.
DR EMBL; BC145961; AAI45962.1; -; mRNA.
DR EMBL; BC145963; AAI45964.1; -; mRNA.
DR CCDS; CCDS17952.1; -.
DR RefSeq; NP_035075.2; NM_010945.2.
DR AlphaFoldDB; O35242; -.
DR SMR; O35242; -.
DR BioGRID; 201861; 1.
DR STRING; 10090.ENSMUSP00000029910; -.
DR iPTMnet; O35242; -.
DR PhosphoSitePlus; O35242; -.
DR EPD; O35242; -.
DR MaxQB; O35242; -.
DR PaxDb; 10090-ENSMUSP00000029910; -.
DR PeptideAtlas; O35242; -.
DR ProteomicsDB; 267570; -.
DR Pumba; O35242; -.
DR Antibodypedia; 11802; 149 antibodies from 25 providers.
DR DNASU; 18201; -.
DR Ensembl; ENSMUST00000029910.12; ENSMUSP00000029910.6; ENSMUSG00000028245.16.
DR GeneID; 18201; -.
DR KEGG; mmu:18201; -.
DR UCSC; uc008rxp.2; mouse.
DR AGR; MGI:1341864; -.
DR CTD; 8439; -.
DR MGI; MGI:1341864; Nsmaf.
DR VEuPathDB; HostDB:ENSMUSG00000028245; -.
DR eggNOG; KOG1786; Eukaryota.
DR GeneTree; ENSGT00940000155059; -.
DR HOGENOM; CLU_000218_5_2_1; -.
DR InParanoid; O35242; -.
DR OMA; LLKFPGC; -.
DR OrthoDB; 47483at2759; -.
DR PhylomeDB; O35242; -.
DR TreeFam; TF324912; -.
DR Reactome; R-MMU-5626978; TNFR1-mediated ceramide production.
DR BioGRID-ORCS; 18201; 5 hits in 81 CRISPR screens.
DR ChiTaRS; Nsmaf; mouse.
DR PRO; PR:O35242; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; O35242; Protein.
DR Bgee; ENSMUSG00000028245; Expressed in undifferentiated genital tubercle and 263 other cell types or tissues.
DR ExpressionAtlas; O35242; baseline and differential.
DR Genevisible; O35242; MM.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0005123; F:death receptor binding; TAS:MGI.
DR GO; GO:0035591; F:signaling adaptor activity; ISO:MGI.
DR GO; GO:0016230; F:sphingomyelin phosphodiesterase activator activity; ISO:MGI.
DR GO; GO:0034250; P:positive regulation of amide metabolic process; IMP:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:0045834; P:positive regulation of lipid metabolic process; IMP:MGI.
DR GO; GO:1905038; P:regulation of membrane lipid metabolic process; IMP:MGI.
DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IMP:MGI.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF162; PROTEIN FAN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..920
FT /note="Protein FAN"
FT /id="PRO_0000050976"
FT DOMAIN 176..247
FT /note="GRAM"
FT DOMAIN 189..286
FT /note="BEACH-type PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01119"
FT DOMAIN 290..575
FT /note="BEACH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00026"
FT REPEAT 631..661
FT /note="WD 1"
FT REPEAT 673..703
FT /note="WD 2"
FT REPEAT 715..743
FT /note="WD 3"
FT REPEAT 764..794
FT /note="WD 4"
FT REPEAT 806..836
FT /note="WD 5"
FT REPEAT 887..917
FT /note="WD 6"
FT CONFLICT 385..386
FT /note="RF -> KS (in Ref. 1; AAB65394)"
FT /evidence="ECO:0000305"
FT CONFLICT 390
FT /note="S -> N (in Ref. 1; AAB65394)"
FT /evidence="ECO:0000305"
FT CONFLICT 849
FT /note="E -> D (in Ref. 1; AAB65394)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 920 AA; 104546 MW; BB50AD4AB77CE124 CRC64;
MAFTRKRQRE QQLQLYSKER FSLLLLNLEE YYFEQHTAFH VQHQGSQEER KIRGSLKICS
KSVIFEPDAI SQPILKIPLR DCLKIGKHGE NGANKHFAKA KSWGISLIFS QIYFIKEHNI
VAPYKIERGK MEYVFELEVS GKVEDVVETL LQLHRASCLD KLGDQMAMIT AILQSRLART
SFDKNRFQSV SEKLHMECKA EMVTPLVTNP GHVCITDTSL YFQPLNGYPK PVVQITLQDV
RRIYKRRHGL MPLGLEVFCT DDDLCSDIYL KFYEPQDRDD LYFYIATYLE HHAAEHTAES
YMLQWQRGHL SNYQYLLHLN NLADRSCNDL SQYPVFPWII SDYSSPELDL SNPATFRDLS
KPVGALNAER LERLLTRYQE MPEPRFMYGS HYSSPGYVLF YLVRIAPEYM LCLQNGRFDN
ADRMFNSIAE TWKNCLDGAT DFKELIPEFY DEDVSFLVNS LKLDLGKRQG GQMVDDVDLP
AWASSPQDFL QKNKDALESG YVSEHLHEWI DLIFGYKQKG SEAIGAHNVF HPLTYEGGVD
LNSIEDPDEK VAMLTQILEF GQTPKQLFVT PHPRRITPKF KSLSQASSYN ASLTDSPVSP
GEESFEDLTE ESRTLAWSNI AKLQLHEQYK IHKEAVTGIA VSCNGSSVFT TSQDSTLKMF
SKESKMLQRS ISFSNMALSS CLLLPGDTTV ISSSWDNNVY FYSIAFGRRQ DTLMGHDDAV
SKICWHNDRL YSGSWDSTVK VWSGVPAEMP GTKRHQFDLL AELEHDVSVN TINLNAVSTL
LVSGTKEGMV NIWDLTTATL LHQTSCHSGT VCDAAFSPDS RHILSTGVDG CLNVIDVQTG
MLISSMASEE PQRCFVWDGN SVLSGSRSGE LLVWDLLGAK VSERIQGHTG AVTCMWMNEQ
CSSIITGGED RQIMFWKLQY
//
