ID DHX15_MOUSE Reviewed; 795 AA.
AC O35286; Q99L91;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 06-JUN-2003, sequence version 2.
DT 03-APR-2013, entry version 119.
DE RecName: Full=Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15;
DE EC=3.6.4.13;
DE AltName: Full=DEAH box protein 15;
GN Name=Dhx15; Synonyms=Ddx15, Deah9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9342318; DOI=10.1073/pnas.94.22.11803;
RA Gee S., Krauss S.W., Miller E., Aoyagi K., Arenas J., Conboy J.G.;
RT "Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of
RT Saccharomyces cerevisiae splicing factor Prp43.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:11803-11807(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Pre-mRNA processing factor involved in disassembly of
CC spliceosomes after the release of mature mRNA (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC -!- SUBUNIT: Interacts with SSB/La. Component of the U11/U12 snRNPs
CC that are part of the U12-type spliceosome (By similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus (By similarity).
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC subfamily. DDX15/PRP43 sub-subfamily.
CC -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=BC003745; Type=Frameshift; Positions=409;
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DR EMBL; AF017153; AAC36129.1; -; mRNA.
DR EMBL; BC003745; -; NOT_ANNOTATED_CDS; mRNA.
DR IPI; IPI00128818; -.
DR RefSeq; NP_031865.2; NM_007839.2.
DR UniGene; Mm.993; -.
DR ProteinModelPortal; O35286; -.
DR SMR; O35286; 115-787.
DR PhosphoSite; O35286; -.
DR PaxDb; O35286; -.
DR PRIDE; O35286; -.
DR Ensembl; ENSMUST00000031061; ENSMUSP00000031061; ENSMUSG00000029169.
DR GeneID; 13204; -.
DR KEGG; mmu:13204; -.
DR CTD; 1665; -.
DR MGI; MGI:1099786; Dhx15.
DR eggNOG; COG1643; -.
DR HOGENOM; HOG000175261; -.
DR HOVERGEN; HBG039428; -.
DR InParanoid; O35286; -.
DR KO; K12820; -.
DR OMA; TVLQIHA; -.
DR OrthoDB; EOG4K6G3N; -.
DR NextBio; 283358; -.
DR ArrayExpress; O35286; -.
DR Bgee; O35286; -.
DR CleanEx; MM_DHX15; -.
DR Genevestigator; O35286; -.
DR GermOnline; ENSMUSG00000029169; Mus musculus.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005689; C:U12-type spliceosomal complex; ISS:HGNC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR011709; DUF1605.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF04408; HA2; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 2: Evidence at transcript level;
KW Acetylation; ATP-binding; Complete proteome; Helicase; Hydrolase;
KW mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1 795 Putative pre-mRNA-splicing factor ATP-
FT dependent RNA helicase DHX15.
FT /FTId=PRO_0000055140.
FT DOMAIN 147 313 Helicase ATP-binding.
FT DOMAIN 338 518 Helicase C-terminal.
FT NP_BIND 160 167 ATP (By similarity).
FT MOTIF 260 263 DEAH box.
FT COMPBIAS 346 349 Poly-Glu.
FT COMPBIAS 395 398 Poly-Gln.
FT COMPBIAS 403 406 Poly-Pro.
FT MOD_RES 132 132 N6-acetyllysine (By similarity).
FT MOD_RES 488 488 N6-acetyllysine (By similarity).
FT CONFLICT 388 389 LY -> FS (in Ref. 1).
FT CONFLICT 391 393 TLP -> YTS (in Ref. 1).
FT CONFLICT 757 758 WL -> CW (in Ref. 1).
FT CONFLICT 759 795 Missing (in Ref. 1).
SQ SEQUENCE 795 AA; 91007 MW; 25A97254318E497A CRC64;
MSKRHRLDLG EDYPSGKKRA GTDGKDRERD RDREDRSKDR DRERDRGDRE REREKEKEKE
LRASTNAMLI SAGLPPLKAS HSAHSTHSAH STHSTHSAHS THTGHTGHTS LPQCINPFTN
LPHTPRYYDI LKKRLQLPVW EYKDRFTDIL VRHQSFVLVG ETGSGKTTQI PQWCVEYMRS
LPGPKRGVAC TQPRRVAAMS VAQRVADEMD VMLGQEVGYS IRFEDCSSAK TILKYMTDGM
LLREAMNDPL LERYGVIILD EAHERTLATD ILMGVLKEVV RQRSDLKVIV MSATLDAGKF
QIYFDNCPLL TIPGRTHPVE IFYTPEPERD YLEAAIRTVI QIHMCEEEEG DLLLFLTGQE
EIDEACKRIK REVDDLGPEV GDIKIIPLYS TLPPQQQQRI FEPPPPKKQN GAIGRKVVVS
TNIAETSLTI DGVVFVIDPG FAKQKVYNPR IRVESLLVTA ISKASAQQRA GRAGRTRPGK
CFRLYTEKAY KTEMQDNTYP EILRSNLGSV VLQLKKLGID DLVHFDFMDP PAPETLMRAL
ELLNYLAALN DDGDLTELGS MMAEFPLDPQ LAKMVIASCD YNCSNEVLSI TAMLSVPQCF
VRPTEAKKAA DEAKMRFAHI DGDHLTLLNV YHAFKQNHES VQWCYDNFIN YRSLMSADNV
RQQLSRIMDR FNLPRRSTDF TSRDYYINIR KALVTGYFMQ VAHLERTGHY LTVKDNQVVQ
LHPSTVLDHK PEWVLYNEFV LTTKNYIRTC TDIKPEWLVK IAPQYYDMSN FPQCEAKRQL
DRIIAKLQSK EYSQY
//
