ID OPSG_MOUSE Reviewed; 359 AA.
AC O35599; Q548Z4;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 01-MAY-2013, entry version 100.
DE RecName: Full=Medium-wave-sensitive opsin 1;
DE AltName: Full=Green cone photoreceptor pigment;
DE AltName: Full=Green-sensitive opsin;
DE Short=M opsin;
DE AltName: Full=Medium wavelength-sensitive cone opsin;
GN Name=Opn1mw; Synonyms=Gcp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9238068; DOI=10.1073/pnas.94.16.8860;
RA Sun H., Macke J.P., Nathans J.;
RT "Mechanisms of spectral tuning in the mouse green cone pigment.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:8860-8865(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=BALB/c, and C57BL/10;
RX PubMed=11055434; DOI=10.1016/S0896-6273(00)00062-3;
RA Applebury M.L., Antoch M.P., Baxter L.C., Chun L.Y., Falk J.D.,
RA Farhangfar F., Kage K., Krzystolik M.G., Lyass L.A., Robbins J.T.;
RT "The murine cone photoreceptor: a single cone type expresses both S
RT and M opsins with retinal spatial patterning.";
RL Neuron 27:513-523(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6; TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently
CC linked to cis-retinal. May increase spectral sensitivity in dim
CC light.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in cone photoreceptor cells.
CC -!- PTM: Phosphorylated on some or all of the serine and threonine
CC residues present in the C-terminal region (By similarity).
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Opsin subfamily.
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DR EMBL; AF011389; AAB64302.1; -; mRNA.
DR EMBL; AF190672; AAG17991.1; -; mRNA.
DR EMBL; AF191085; AAG17992.1; -; Genomic_DNA.
DR EMBL; AF191080; AAG17992.1; JOINED; Genomic_DNA.
DR EMBL; AF191081; AAG17992.1; JOINED; Genomic_DNA.
DR EMBL; AF191082; AAG17992.1; JOINED; Genomic_DNA.
DR EMBL; AF191083; AAG17992.1; JOINED; Genomic_DNA.
DR EMBL; AF191084; AAG17992.1; JOINED; Genomic_DNA.
DR EMBL; BC014826; AAH14826.1; -; mRNA.
DR IPI; IPI00131882; -.
DR RefSeq; NP_032132.1; NM_008106.2.
DR UniGene; Mm.284825; -.
DR ProteinModelPortal; O35599; -.
DR SMR; O35599; 32-329.
DR PhosphoSite; O35599; -.
DR PRIDE; O35599; -.
DR Ensembl; ENSMUST00000033771; ENSMUSP00000033771; ENSMUSG00000031394.
DR GeneID; 14539; -.
DR KEGG; mmu:14539; -.
DR CTD; 2652; -.
DR MGI; MGI:1097692; Opn1mw.
DR eggNOG; NOG240324; -.
DR GeneTree; ENSGT00700000104057; -.
DR HOGENOM; HOG000253932; -.
DR HOVERGEN; HBG107442; -.
DR KO; K04251; -.
DR OrthoDB; EOG40K806; -.
DR NextBio; 286212; -.
DR ArrayExpress; O35599; -.
DR Bgee; O35599; -.
DR Genevestigator; O35599; -.
DR GermOnline; ENSMUSG00000031394; Mus musculus.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0001750; C:photoreceptor outer segment; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR GO; GO:0018298; P:protein-chromophore linkage; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR000378; Opsin_red/grn.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR00575; OPSINREDGRN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 1: Evidence at protein level;
KW Chromophore; Complete proteome; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein;
KW Photoreceptor protein; Receptor; Reference proteome; Retinal protein;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix;
KW Vision.
FT CHAIN 1 359 Medium-wave-sensitive opsin 1.
FT /FTId=PRO_0000197786.
FT TOPO_DOM 1 47 Extracellular (Potential).
FT TRANSMEM 48 72 Helical; Name=1; (Potential).
FT TOPO_DOM 73 84 Cytoplasmic (Potential).
FT TRANSMEM 85 110 Helical; Name=2; (Potential).
FT TOPO_DOM 111 124 Extracellular (Potential).
FT TRANSMEM 125 144 Helical; Name=3; (Potential).
FT TOPO_DOM 145 163 Cytoplasmic (Potential).
FT TRANSMEM 164 187 Helical; Name=4; (Potential).
FT TOPO_DOM 188 213 Extracellular (Potential).
FT TRANSMEM 214 241 Helical; Name=5; (Potential).
FT TOPO_DOM 242 263 Cytoplasmic (Potential).
FT TRANSMEM 264 287 Helical; Name=6; (Potential).
FT TOPO_DOM 288 295 Extracellular (Potential).
FT TRANSMEM 296 320 Helical; Name=7; (Potential).
FT TOPO_DOM 321 359 Cytoplasmic (Potential).
FT MOD_RES 307 307 N6-(retinylidene)lysine.
FT CARBOHYD 29 29 N-linked (GlcNAc...) (Probable).
FT DISULFID 121 198 Potential.
SQ SEQUENCE 359 AA; 40218 MW; 1BB5F531A6FAE357 CRC64;
MAQRLTGEQT LDHYEDSTHA SIFTYTNSNS TKGPFEGPNY HIAPRWVYHL TSTWMILVVV
ASVFTNGLVL AATMRFKKLR HPLNWILVNL AVADLAETII ASTISVVNQI YGYFVLGHPL
CVIEGYIVSL CGITGLWSLA IISWERWLVV CKPFGNVRFD AKLATVGIVF SWVWAAIWTA
PPIFGWSRYW PYGLKTSCGP DVFSGTSYPG VQSYMMVLMV TCCIFPLSII VLCYLQVWLA
IRAVAKQQKE SESTQKAEKE VTRMVVVMVF AYCLCWGPYT FFACFATAHP GYAFHPLVAS
LPSYFAKSAT IYNPIIYVFM NRQFRNCILH LFGKKVDDSS ELSSTSKTEV SSVSSVSPA
//
