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Database: UniProt
Entry: O35599
LinkDB: O35599
Original site: O35599 
ID   OPSG_MOUSE              Reviewed;         359 AA.
AC   O35599; Q548Z4;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-SEP-2014, entry version 110.
DE   RecName: Full=Medium-wave-sensitive opsin 1;
DE   AltName: Full=Green cone photoreceptor pigment;
DE   AltName: Full=Green-sensitive opsin;
DE            Short=M opsin;
DE   AltName: Full=Medium wavelength-sensitive cone opsin;
GN   Name=Opn1mw; Synonyms=Gcp;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9238068; DOI=10.1073/pnas.94.16.8860;
RA   Sun H., Macke J.P., Nathans J.;
RT   "Mechanisms of spectral tuning in the mouse green cone pigment.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:8860-8865(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=BALB/c, and C57BL/10;
RX   PubMed=11055434; DOI=10.1016/S0896-6273(00)00062-3;
RA   Applebury M.L., Antoch M.P., Baxter L.C., Chun L.Y., Falk J.D.,
RA   Farhangfar F., Kage K., Krzystolik M.G., Lyass L.A., Robbins J.T.;
RT   "The murine cone photoreceptor: a single cone type expresses both S
RT   and M opsins with retinal spatial patterning.";
RL   Neuron 27:513-523(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6; TISSUE=Retina;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC       mediate vision. They consist of an apoprotein, opsin, covalently
CC       linked to cis-retinal. May increase spectral sensitivity in dim
CC       light.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in cone photoreceptor cells.
CC   -!- PTM: Phosphorylated on some or all of the serine and threonine
CC       residues present in the C-terminal region (By similarity).
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Opsin subfamily.
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DR   EMBL; AF011389; AAB64302.1; -; mRNA.
DR   EMBL; AF190672; AAG17991.1; -; mRNA.
DR   EMBL; AF191085; AAG17992.1; -; Genomic_DNA.
DR   EMBL; AF191080; AAG17992.1; JOINED; Genomic_DNA.
DR   EMBL; AF191081; AAG17992.1; JOINED; Genomic_DNA.
DR   EMBL; AF191082; AAG17992.1; JOINED; Genomic_DNA.
DR   EMBL; AF191083; AAG17992.1; JOINED; Genomic_DNA.
DR   EMBL; AF191084; AAG17992.1; JOINED; Genomic_DNA.
DR   EMBL; BC014826; AAH14826.1; -; mRNA.
DR   CCDS; CCDS30220.1; -.
DR   RefSeq; NP_032132.1; NM_008106.2.
DR   UniGene; Mm.284825; -.
DR   ProteinModelPortal; O35599; -.
DR   SMR; O35599; 16-354.
DR   PhosphoSite; O35599; -.
DR   PRIDE; O35599; -.
DR   Ensembl; ENSMUST00000033771; ENSMUSP00000033771; ENSMUSG00000031394.
DR   GeneID; 14539; -.
DR   KEGG; mmu:14539; -.
DR   UCSC; uc009tnv.1; mouse.
DR   CTD; 2652; -.
DR   MGI; MGI:1097692; Opn1mw.
DR   eggNOG; NOG240324; -.
DR   GeneTree; ENSGT00710000106574; -.
DR   HOGENOM; HOG000253932; -.
DR   HOVERGEN; HBG107442; -.
DR   KO; K04251; -.
DR   OrthoDB; EOG72NRQJ; -.
DR   PhylomeDB; O35599; -.
DR   TreeFam; TF324998; -.
DR   Reactome; REACT_196615; Retinoid cycle disease events.
DR   Reactome; REACT_196617; The retinoid cycle in cones (daylight vision).
DR   NextBio; 286212; -.
DR   PRO; PR:O35599; -.
DR   Bgee; O35599; -.
DR   Genevestigator; O35599; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001750; C:photoreceptor outer segment; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:MGI.
DR   GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR   GO; GO:0018298; P:protein-chromophore linkage; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1070.10; -; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001760; Opsin.
DR   InterPro; IPR000378; Opsin_red/grn.
DR   InterPro; IPR027430; Retinal_BS.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00238; OPSIN.
DR   PRINTS; PR00575; OPSINREDGRN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   PROSITE; PS00238; OPSIN; 1.
PE   1: Evidence at protein level;
KW   Chromophore; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein;
KW   Photoreceptor protein; Receptor; Reference proteome; Retinal protein;
KW   Sensory transduction; Transducer; Transmembrane; Transmembrane helix;
KW   Vision.
FT   CHAIN         1    359       Medium-wave-sensitive opsin 1.
FT                                /FTId=PRO_0000197786.
FT   TOPO_DOM      1     47       Extracellular (Potential).
FT   TRANSMEM     48     72       Helical; Name=1; (Potential).
FT   TOPO_DOM     73     84       Cytoplasmic (Potential).
FT   TRANSMEM     85    110       Helical; Name=2; (Potential).
FT   TOPO_DOM    111    124       Extracellular (Potential).
FT   TRANSMEM    125    144       Helical; Name=3; (Potential).
FT   TOPO_DOM    145    163       Cytoplasmic (Potential).
FT   TRANSMEM    164    187       Helical; Name=4; (Potential).
FT   TOPO_DOM    188    213       Extracellular (Potential).
FT   TRANSMEM    214    241       Helical; Name=5; (Potential).
FT   TOPO_DOM    242    263       Cytoplasmic (Potential).
FT   TRANSMEM    264    287       Helical; Name=6; (Potential).
FT   TOPO_DOM    288    295       Extracellular (Potential).
FT   TRANSMEM    296    320       Helical; Name=7; (Potential).
FT   TOPO_DOM    321    359       Cytoplasmic (Potential).
FT   MOD_RES     307    307       N6-(retinylidene)lysine.
FT   CARBOHYD     29     29       N-linked (GlcNAc...) (Probable).
FT   DISULFID    121    198       Potential.
SQ   SEQUENCE   359 AA;  40218 MW;  1BB5F531A6FAE357 CRC64;
     MAQRLTGEQT LDHYEDSTHA SIFTYTNSNS TKGPFEGPNY HIAPRWVYHL TSTWMILVVV
     ASVFTNGLVL AATMRFKKLR HPLNWILVNL AVADLAETII ASTISVVNQI YGYFVLGHPL
     CVIEGYIVSL CGITGLWSLA IISWERWLVV CKPFGNVRFD AKLATVGIVF SWVWAAIWTA
     PPIFGWSRYW PYGLKTSCGP DVFSGTSYPG VQSYMMVLMV TCCIFPLSII VLCYLQVWLA
     IRAVAKQQKE SESTQKAEKE VTRMVVVMVF AYCLCWGPYT FFACFATAHP GYAFHPLVAS
     LPSYFAKSAT IYNPIIYVFM NRQFRNCILH LFGKKVDDSS ELSSTSKTEV SSVSSVSPA
//
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