ID O41956_MHV68 Unreviewed; 383 AA.
AC O41956;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=39 protein {ECO:0000313|EMBL:AAF19304.1};
DE SubName: Full=Glycoprotein M {ECO:0000313|EMBL:AAB66437.1};
GN Name=GAMMAHV.ORF39 {ECO:0000313|EMBL:AAB66437.1};
GN Synonyms=39 {ECO:0000313|EMBL:AAF19304.1};
OS Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Gammaherpesvirinae; Rhadinovirus;
OC Rhadinovirus muridgamma4.
OX NCBI_TaxID=33708 {ECO:0000313|EMBL:AAB66437.1};
OH NCBI_TaxID=10129; Apodemus sylvaticus (European woodmouse).
RN [1] {ECO:0000313|Proteomes:UP000099649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=8083987;
RA Stewart J.P., Janjua N.J., Sunil-Chandra N.P., Nash A.A., Arrand J.R.;
RT "Characterization of murine gammaherpesvirus 68 glycoprotein B (gB)
RT homolog: similarity to Epstein-Barr virus gB (gp110).";
RL J. Virol. 68:6496-6504(1994).
RN [2] {ECO:0000313|Proteomes:UP000099649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=8648686;
RA Stewart J.P., Janjua N.J., Pepper S.D., Bennion G., Mackett M., Allen T.,
RA Nash A.A., Arrand J.R.;
RT "Identification and characterization of murine gammaherpesvirus 68 gp150: a
RT virion membrane glycoprotein.";
RL J. Virol. 70:3528-3535(1996).
RN [3] {ECO:0000313|Proteomes:UP000099649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=8638414; DOI=10.1006/viro.1996.0274;
RA Pepper S.D., Stewart J.P., Arrand J.R., Mackett M.;
RT "Murine gammaherpesvirus-68 encodes homologues of thymidine kinase and
RT glycoprotein H: sequence, expression, and characterization of pyrimidine
RT kinase activity.";
RL Virology 219:475-479(1996).
RN [4] {ECO:0000313|EMBL:AAF19304.1, ECO:0000313|Proteomes:UP000099649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G2.4 {ECO:0000313|EMBL:AAF19304.1};
RX PubMed=9191940;
RA Mackett M., Stewart J.P., de V Pepper S., Chee M., Efstathiou S.,
RA Nash A.A., Arrand J.R.;
RT "Genetic content and preliminary transcriptional analysis of a
RT representative region of murine gammaherpesvirus 68.";
RL J. Gen. Virol. 78:1425-1433(1997).
RN [5] {ECO:0000313|Proteomes:UP000099649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=9225045;
RA Bowden R.J., Simas J.P., Davis A.J., Efstathiou S.;
RT "Murine gammaherpesvirus 68 encodes tRNA-like sequences which are expressed
RT during latency.";
RL J. Gen. Virol. 78:1675-1687(1997).
RN [6] {ECO:0000313|EMBL:AAB66437.1, ECO:0000313|Proteomes:UP000099649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G2.4 {ECO:0000313|EMBL:AAF19304.1}, and WUMS
RC {ECO:0000313|EMBL:AAB66437.1};
RX PubMed=9223479;
RA Virgin H.W.IV., Latreille P., Wamsley P., Hallsworth K., Weck K.E.,
RA Dal Canto A.J., Speck S.H.;
RT "Complete sequence and genomic analysis of murine gammaherpesvirus 68.";
RL J. Virol. 71:5894-5904(1997).
RN [7] {ECO:0000313|EMBL:AAF19304.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=G2.4 {ECO:0000313|EMBL:AAF19304.1};
RA Milligan S., Efstathiou S., Stewart J.P., Nash A.A., Davison A.J.;
RT "Genetic content of murine gammaherpesviruses.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:AAB66437.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WUMS {ECO:0000313|EMBL:AAB66437.1};
RA Lynn T., Virgin H.W.;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:ACV65517.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=4556 {ECO:0000313|EMBL:ACV65517.1};
RA Halasova Z., Valovicova M., Belvoncikova P., Pancik P., Rezuchova I.,
RA Kudelova M.;
RT "Partial sequence and analysis of Murine herpesvirus strain 4556 (MHV4556)
RT genome.";
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Envelope glycoprotein important for virion assembly and
CC egress. Plays a role in the correct incorporation of gH-gL into virion
CC membrane. Directs the glycoprotein N (gN) to the host trans-Golgi
CC network. {ECO:0000256|ARBA:ARBA00003017}.
CC -!- INTERACTION:
CC O41956; P88992: BKRF1; NbExp=3; IntAct=EBI-9640701, EBI-9641262;
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DR EMBL; U97553; AAB66437.1; -; Genomic_DNA.
DR EMBL; AF105037; AAF19304.1; -; Genomic_DNA.
DR EMBL; GQ421306; ACV65517.1; -; Genomic_DNA.
DR RefSeq; NP_044877.1; NC_001826.2.
DR DIP; DIP-47205N; -.
DR IntAct; O41956; 2.
DR MINT; O41956; -.
DR GeneID; 1497194; -.
DR KEGG; vg:1497194; -.
DR OrthoDB; 7915at10239; -.
DR Proteomes; UP000099649; Genome.
DR Proteomes; UP000175018; Genome.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0044201; C:host cell nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR HAMAP; MF_04035; HSV_GM; 1.
DR InterPro; IPR000785; Herpes_glycop_M.
DR Pfam; PF01528; Herpes_glycop; 1.
DR PRINTS; PR00333; HSVINTEGRLMP.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000099649};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 360..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 383 AA; 43768 MW; 23D78027BD86A25D CRC64;
MPALKVPQLK KLEPSRSDSF LLKSWTNLLA LLTLLFVTSS TVPILASFRG VGFPCYFVNL
VDYSTLNLTV RNSAKHLTPT LFLEGPEMFV YIVWSFLTEA INIIYFIFGA VTVYRLKKIF
MPSLNAIQVW LTLIGGHSTL YLSIARLWTL QLFVHVLSFK QIFLAAFVYL FHFMLSYVHV
HVFISRYVPQ WQANDMEQKI PEGSSLEKLV LFYRPILANI QMSLLALEML VFSLSVMMAV
CNSFYILVSD AVFGAVNLFL IISLVWHIGA EVFLAKYLRH HVGFYIGLFV AYVIMLLPVI
RYDAIFVTSR LHKPITINMT IIPIICLIII VVRIIRLRSQ TSTKVTYKKL GISGAMEAQP
FQSIPQPPRA KYTDLETESE DEL
//
