ID O42336_MYOSC Unreviewed; 184 AA.
AC O42336;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=Insulin {ECO:0000256|ARBA:ARBA00020180};
DE Flags: Precursor;
GN Name=IGF-I {ECO:0000313|EMBL:CAA73162.1};
OS Myoxocephalus scorpius (Shorthorn sculpin) (Cottus scorpius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Cottales; Cottidae; Myoxocephalus.
OX NCBI_TaxID=8097 {ECO:0000313|EMBL:CAA73162.1};
RN [1] {ECO:0000313|EMBL:CAA73162.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9723899; DOI=10.1016/S0303-7207(98)00057-4;
RA Loffing-Cueni DNN, Schmid ACC, Graf H, Reinecke M;
RT "IGF-I in the bony fish Cottus scorpius: cDNA, expression and differential
RT localization in brain and islets.";
RL Mol. Cell. Endocrinol. 141:187-194(1998).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Y12583; CAA73162.1; -; mRNA.
DR AlphaFoldDB; O42336; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04368; IlGF; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022341; IGF-I.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR022350; Insulin-like_growth_factor.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46845:SF3; INSULIN-LIKE GROWTH FACTOR 1; 1.
DR PANTHER; PTHR46845; INSULIN-LIKE GROWTH FACTOR I; 1.
DR Pfam; PF00049; Insulin; 2.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02005; INSLNLIKEGF1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR622350-50};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406}.
FT DOMAIN 47..103
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 110..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 50..90
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 62..103
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 89..94
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
SQ SEQUENCE 184 AA; 20345 MW; BD60E98FE5F25039 CRC64;
MSSALSFQWH LCDVFKSAMC CISCSHTLSL LLCVLTLSLT ATRAGPETLC GAELVDTLQF
VCGERGFYFS KPGGYGPNAR RSRGIVDECC FQSCELRRLE MYCAPPKTSK AARSVRAQRH
TDRAPKVSAA GHKVDKSTER RTAQQPGKTK NKKRPLPGHS HSSFKDVHQK NSSRGTMGGR
NYRM
//
