ID RX3_DANRE Reviewed; 292 AA.
AC O42358;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 134.
DE RecName: Full=Retinal homeobox protein Rx3;
GN Name=rx3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=9177348; DOI=10.1038/42475;
RA Mathers P.H., Grinberg A., Mahon K.A., Jamrich M.;
RT "The Rx homeobox gene is essential for vertebrate eye development.";
RL Nature 387:603-607(1997).
CC -!- FUNCTION: Plays a critical role in eye formation by regulating the
CC initial specification of retinal cells and/or their subsequent
CC proliferation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|PROSITE-ProRule:PRU00138}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the ventral forebrain.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
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DR EMBL; AF001909; AAB62327.1; -; mRNA.
DR RefSeq; NP_571302.1; NM_131227.1.
DR AlphaFoldDB; O42358; -.
DR SMR; O42358; -.
DR STRING; 7955.ENSDARP00000069319; -.
DR PaxDb; 7955-ENSDARP00000069319; -.
DR GeneID; 30474; -.
DR KEGG; dre:30474; -.
DR AGR; ZFIN:ZDB-GENE-990415-238; -.
DR CTD; 30474; -.
DR ZFIN; ZDB-GENE-990415-238; rx3.
DR eggNOG; KOG0490; Eukaryota.
DR InParanoid; O42358; -.
DR OrthoDB; 3042435at2759; -.
DR PhylomeDB; O42358; -.
DR PRO; PR:O42358; -.
DR Proteomes; UP000000437; Chromosome 21.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0021984; P:adenohypophysis development; IMP:ZFIN.
DR GO; GO:0048593; P:camera-type eye morphogenesis; IMP:ZFIN.
DR GO; GO:0001708; P:cell fate specification; IMP:ZFIN.
DR GO; GO:0048596; P:embryonic camera-type eye morphogenesis; IMP:ZFIN.
DR GO; GO:0001654; P:eye development; IMP:ZFIN.
DR GO; GO:0060898; P:eye field cell fate commitment involved in camera-type eye formation; IMP:ZFIN.
DR GO; GO:0030900; P:forebrain development; IMP:ZFIN.
DR GO; GO:0021854; P:hypothalamus development; IMP:ZFIN.
DR GO; GO:0001755; P:neural crest cell migration; IMP:ZFIN.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR InterPro; IPR043562; RAX/RAX2.
DR PANTHER; PTHR46271; HOMEOBOX PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR46271:SF3; RETINAL HOMEOBOX PROTEIN RX; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..292
FT /note="Retinal homeobox protein Rx3"
FT /id="PRO_0000049285"
FT DNA_BIND 106..165
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 32..39
FT /note="Octapeptide motif"
FT MOTIF 272..285
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT MOTIF 278..282
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 292 AA; 32757 MW; 391892B067AA7A96 CRC64;
MRLVGSQYKD MEDRLSPSAR LVRSPGSQTR IHSIESILGF KGETLFHPAF PYGSGKTGKD
TEHLSPKKDS NKHFDGVCRS TVMVSPDLPD ADGGKLSDDE NPKKKHRRNR TTFTTFQLHE
LERAFEKSHY PDVYSREELA LKVNLPEVRV QVWFQNRRAK WRRQEKLEVS SIKLQESSML
SIPRSGPLSL GSGLPLEPWL TGPISTSSSP LQSLPSFITP QQAVPASYTP PQFLSSSTLN
HSLPHIGAVC PPYQCSGFMD KFSLQEADPR NTSIASLRMK AKEHIQSIGK TW
//
