ID O44113_DROME Unreviewed; 2559 AA.
AC O44113;
DT 01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JUN-1998, sequence version 1.
DT 03-APR-2013, entry version 90.
DE SubName: Full=Putative guanine nucleotide exchange factor RhoGEF2;
GN Name=RhoGEF2; Synonyms=rhoGEF2; ORFNames=CG9635;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9428514; DOI=10.1016/S0092-8674(00)80482-1;
RA Barrett K., Leptin M., Settleman J.;
RT "The Rho GTPase and a putative RhoGEF mediate a signaling pathway for
RT the cell shape changes in Drosophila gastrulation.";
RL Cell 91:905-915(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RA Haecker U., Perrimon N.;
RT "DRhoGEF2 encodes a member of the Dbl-family of oncogenes and
RT orchestrates cell shape changes during gastrulation in Drosophila.";
RL Genes Dev. 0:0-0(1998).
CC -!- SIMILARITY: Contains 1 DH (DBL-homology) domain.
CC -!- SIMILARITY: Contains 1 PDZ (DHR) domain.
CC -!- SIMILARITY: Contains 1 PH domain.
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DR EMBL; AF031930; AAB88816.1; -; mRNA.
DR PIR; T09144; T09144.
DR HSSP; O14745; 1I92.
DR ProteinModelPortal; O44113; -.
DR STRING; 7227.FBpp0086124; -.
DR STRING; O44113; -.
DR PRIDE; O44113; -.
DR FlyBase; FBgn0023172; RhoGEF2.
DR InParanoid; O44113; -.
DR ChiTaRS; RhoGEF2; drosophila.
DR ArrayExpress; O44113; -.
DR Bgee; O44113; -.
DR GO; GO:0030478; C:actin cap; IDA:FlyBase.
DR GO; GO:0005826; C:actomyosin contractile ring; IDA:FlyBase.
DR GO; GO:0045179; C:apical cortex; IDA:FlyBase.
DR GO; GO:0016324; C:apical plasma membrane; IDA:FlyBase.
DR GO; GO:0045178; C:basal part of cell; IDA:FlyBase.
DR GO; GO:0016328; C:lateral plasma membrane; IDA:FlyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; ISS:FlyBase.
DR GO; GO:0031532; P:actin cytoskeleton reorganization; IMP:FlyBase.
DR GO; GO:0007015; P:actin filament organization; IMP:FlyBase.
DR GO; GO:0007375; P:anterior midgut invagination; IMP:FlyBase.
DR GO; GO:0090254; P:cell elongation involved in imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR GO; GO:0007349; P:cellularization; IMP:FlyBase.
DR GO; GO:0007377; P:germ-band extension; IMP:FlyBase.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007277; P:pole cell development; IMP:FlyBase.
DR GO; GO:0007374; P:posterior midgut invagination; IMP:FlyBase.
DR GO; GO:0030589; P:pseudocleavage involved in syncytial blastoderm formation; IMP:FlyBase.
DR GO; GO:0050770; P:regulation of axonogenesis; IGI:FlyBase.
DR GO; GO:0016476; P:regulation of embryonic cell shape; IMP:FlyBase.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0035277; P:spiracle morphogenesis, open tracheal system; IMP:FlyBase.
DR GO; GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007370; P:ventral furrow formation; IMP:FlyBase.
DR Gene3D; 1.20.900.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR011993; PH_like_dom.
DR InterPro; IPR001849; Pleckstrin_homology.
DR InterPro; IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
DR InterPro; IPR015212; Regulat_G_prot_signal-like.
DR InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR InterPro; IPR015721; RhoGEF-like.
DR PANTHER; PTHR22825; PTHR22825; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DH-domain; 1.
DR SUPFAM; SSF50156; PDZ; 1.
DR SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Zinc.
SQ SEQUENCE 2559 AA; 280949 MW; 7BC661AA1E6EB40E CRC64;
MDDPSIKKRL LDLYTDEHEY DEVQEIPEES SIQPPETSTS HTSTNGSSHS GPGTATGPGA
TSAGPSAGAP QSPVIVVDSV PELPAPKQKS VKNSKSKQKQ KQLANKSKIP RSPSLASSLS
SLASSLSGHR DRDKDRDKDR ENQNAVPPQT PPLPPSYKQN QMNGDSTAAA GGGVSAPATP
TTANNNNASH NNGSIMGGGV QLNQSDNSNP VLQAPGERSS LNLTPLSRDL SGGHTQESTT
PATTPSTPSL ALPKNFQYLT LTVRKDSNGY GMKVSGDNPV FVESVKPGGA AEIAGLVAGD
MILRVNGHEV RLEKHPTVVG LIKASTTVEL AVKRSQKLTR PSSVSVVTPS TPILSGRDRT
ASITGPQPVD SIKRREMETY KIQTLQKMLE QEKLNLERLK SDQNNPSYKL SEANIRKLRE
QLHQVGAEDA PTVKLQAAAG NKNTALLTPN QIQHLSASAT HSNQQFHHLH HHHNLHNNNY
PPQQQPASTS PAFLSLLPRS LSSLSLGTRK NKTEKDLTTS SPFGLTTDFL QQQRMSHQAE
SMSQSMHQHT STPTSQQFFH PHQQQHRFKE TGPTSKGKNK FLISRSLIEE DVPPPLPQRN
PPRQLNLDLK NGNASPGGSH LVAPVSDLDR ATSPQLNRSQ QQQLPRSTDN SPSNAKSKRS
KIKTKALSDP KMSTQMFLQM ESASAAGAAG GSIEVDGGPP PLPPRLPGMM TEDMSRGSCQ
NLAQPNSVGT AFNYPLVSTT TAVQNDNLNI AFPLSQRPNI VQQLQQYQQQ QQHQMSGGQA
TGALGQTPNL GKNKHRRVGS SPDNMHPRHP DRITKTTSGS WEIVEKDGES SPPGTPPPPY
LSSSHMTVLE DPNENNRGAA AAGPGVFIES HQFTPMAGAS SPIPISLHSN HMHAAQSNDT
QKEIISMEDE NSDLDEPFID ENGPFNNLTR LLEAENVTFL AIFLNYVISN SDPAPLLFYL
ITELYKEGTS KDMRKWAYEI HSTFLVPRAP LSWYRQDESL AREVDNVLQL EYDKVEILRT
VFLRSRKRAK DLISEQLREF QQKRTAGLGT IYGPTDDKLA EAKTDKLREQ IIDKYLMPNL
HALIEDENGS PPEDVRKVAL CSALSTVIYR IFNTRPPPSS IVERVHHFVS RDKSFKSRIM
GKNRKMNVRG HPLVLRQYYE VTHCNHCQTI IWGVSPQGYH CTDCKLNIHR QCSKVVDESC
PGPLPQAKRL AHNDKISKFM GKIRPRTSDV IGNEKRSRQD EELNVELTPD RGQASIVRQP
SDRRPDANIS IRSNGNTSCN TSGLNTTDLQ SSFHGSCAND SINPGGGAGC NMDLSTSVAS
TTPSTSGSVA AGLSAFAELN ALDTVDKEAR RERYSQHPKH KSAPVSVNWS ESYKERLSNK
RNRNSRRKTS DPSLSSRPND EQLDLGLSNA TYVGSSNSSL SSAGGTESPS TSMEHFAAPG
AAGGVQVPPM GLNQNQHPHL LIQQHAQQYC QQDSFQAGLA GAAGSSAASN SSFWNAGHPL
PVARWTLESE DEDDVNEADW SSMVAAEVSA ALTDAEKKRQ EIINEIYQTE RNHVRTLKLL
DRLFFLPLYE SGLLSQDHLL LLFPPALLSL REIHGAFEQS LKQRRIEHNH VVNTIGDLLA
DMFDGQSGVV LCEFAAQFCA RQQIALEALK EKRNKDEMLQ KLLKKSESHK ACRRLELKDL
LPTVLQRLTK YPLLFENLYK VTVRLLPENT TEAEAIQRAV ESSKRILVEV NQAVRTAEDA
HKLQNIQRKL DRSSYDKEEF KKLDLTQHHL IHDGNLTIKK NPSVQLHGLL FENMIVLLTK
QDDKYYLKNL HTPLSITNKP VSPIMSIDAD TLIRQEAADK NSFFLIKMKT SQMLELRAPS
SSECKTWFKH FSDVAARQSK NRSKNASSNH DTSISDPALA AIPHSNTKES LELSTDTVQP
LAATATLTTT PLAPMLPIAT VTPAPATNNS NVSSLTGVQL RNPQRDATAS ESDADYVNTP
KPRSSQNEVN RTMSIRSTGE PIQKYSANGT EANDVTLRHS QSTRESVRPG STGEERNSTY
GMVGGNSKRD SASIVCSNNS NNTRTLLMQS PLVDPTAIQV SISPAHTAEP VLTPGEKLRR
LDASIRNDLL EKQKIICDIF RLPVEHYDQI VDIAMMPEAP KDSADIALAA YDQIQTLTKM
LNEYMHVTPE QEVSAVSTAV CGHCHEKEKL RKKVAPSSSF SSSPPPLPPP NRQHAQAQAQ
IPPSRLMPKL QTLDLDEVAI HEDDDGYCEI DELRLPAIPS KPHERPTTPL APFNTEPKTS
QSVIDASKRQ STDAVPEGLL EQEPLEGDKT ETKGEDNEVK TVPSDKLSES CNEERQCVEA
DITKEVADPT TSKNEAAASV DELPSQSREI KTAENASKSV ADKKEDNEET IEEGVASTVD
SSTQTSPTES PKETDKLTGG SSSTCGPNRI QHASVLEPSV PCHALSSIVT ILNEQISMLL
PKINERDMER ERLRKENQHL RELLSALHDR QRVDEVKETP FDLKKLMHAE DVEFDDDIDA
ISNSSLTPTP TPIPTASPSA SGQVETAEAM RITSTEDEE
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