ID O45732_CAEEL Unreviewed; 763 AA.
AC O45732;
DT 01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JUN-1998, sequence version 1.
DT 27-MAR-2024, entry version 168.
DE SubName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000313|EMBL:CAB07650.1};
GN Name=dop-5 {ECO:0000313|EMBL:CAB07650.1,
GN ECO:0000313|WormBase:T02E9.3a};
GN ORFNames=CELE_T02E9.3 {ECO:0000313|EMBL:CAB07650.1}, T02E9.3
GN {ECO:0000313|WormBase:T02E9.3a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB07650.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB07650.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB07650.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; BX284605; CAB07650.1; -; Genomic_DNA.
DR PIR; T24367; T24367.
DR RefSeq; NP_505884.1; NM_073483.6.
DR AlphaFoldDB; O45732; -.
DR SMR; O45732; -.
DR STRING; 6239.T02E9.3.1; -.
DR PaxDb; 6239-T02E9-3; -.
DR EnsemblMetazoa; T02E9.3a.1; T02E9.3a.1; WBGene00011382.
DR GeneID; 179571; -.
DR UCSC; T02E9.3; c. elegans.
DR AGR; WB:WBGene00011382; -.
DR WormBase; T02E9.3a; CE13066; WBGene00011382; dop-5.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_021350_0_0_1; -.
DR InParanoid; O45732; -.
DR OMA; NSAWRPS; -.
DR OrthoDB; 2875965at2759; -.
DR PhylomeDB; O45732; -.
DR Reactome; R-CEL-390650; Histamine receptors.
DR Reactome; R-CEL-418555; G alpha (s) signalling events.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00011382; Expressed in larva and 3 other cell types or tissues.
DR ExpressionAtlas; O45732; baseline and differential.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR CDD; cd14967; 7tmA_amine_R-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24248:SF125; DOPAMINE D2-LIKE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 2.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 2.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:CAB07650.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..735
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 238..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 763 AA; 86117 MW; BEEEF4B1FD20B7DA CRC64;
MLLSVSNGTD QNPQDLNDLQ WNAFHAFLLL LIILVVFGNT MVIFAVAVDR KLRSVTTNKF
IASLAVSDLL VGLIVMPLSL YYKMHNDHWT LGYTWCQFHL VSGVFSTTAS IVHLVAISLD
RYFAIMFPTE YQRHSVSTST VPYVVMIWLM ALAVSSTLFM EQRDSFDGIC WISNPQYIVL
SSFLSFFLPG AIVVYLYMKI FKKLRNHQLY MFGQLTHRGG ERERRHSLPR VIIEEVRSRR
GSRMSQTGSQ SGSPTRRQSG GSKERSPSQP DIHIVAKPQQ RWRSPTICAE TLAHDRLLAA
KKRVSIVPDP PSMDVSVNMA SIDQMKDEHH HNLMREEELL GCEAGRRKQS EEEVRKLSDE
RKRVIYERRR SSTSENPNGI PIMQAFQKAY QEVRAGRRRS TIHDITAYHF PSLTTVNEPA
TPPPGEDCEE KEKDSDGTSI MHKLSSGSSI AETVIAMLPK TSTLSKTDSH ESSVSTEASQ
KPLLGPPTHH YTKKSQTQKE PRYSPSIPAP TFLMVPAMMA VNTPPATPNT KEAPTNCTSL
LQVPRLFDCP SPCSVPSNSS HSSYTSASGS SDTYRRISMN SYGSSLTDGT ESTFECDSRR
SSAWSTIRAA VFDRQQMRGG KASVDITVDR TGSPQKKMST ISRGKLRRIA TQVTRAIRRK
RRESMAIRRE SRATRVVAAI LIAFLICWIP YFCISIFRGV LMGFQININT PIHLTLFVYT
SWLGYAHSCF NPLIYMCLNK NFRNTMRKMM QKTNRAKMAE QEG
//