ID ACP_BORBU Reviewed; 80 AA.
AC O51647;
DT 02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE RecName: Full=Acyl carrier protein {ECO:0000255|HAMAP-Rule:MF_01217};
DE Short=ACP {ECO:0000255|HAMAP-Rule:MF_01217};
GN Name=acpP {ECO:0000255|HAMAP-Rule:MF_01217}; OrderedLocusNames=BB_0704;
OS Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS (Borrelia burgdorferi).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Borreliaceae;
OC Borreliella.
OX NCBI_TaxID=224326;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL Nature 390:580-586(1997).
CC -!- FUNCTION: Carrier of the growing fatty acid chain in fatty acid
CC biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01217}.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP-
CC Rule:MF_01217}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01217}.
CC -!- PTM: 4'-phosphopantetheine is transferred from CoA to a specific serine
CC of apo-ACP by AcpS. This modification is essential for activity because
CC fatty acids are bound in thioester linkage to the sulfhydryl of the
CC prosthetic group. {ECO:0000255|HAMAP-Rule:MF_01217}.
CC -!- SIMILARITY: Belongs to the acyl carrier protein (ACP) family.
CC {ECO:0000255|HAMAP-Rule:MF_01217}.
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DR EMBL; AE000783; AAC67041.1; -; Genomic_DNA.
DR PIR; G70187; G70187.
DR RefSeq; NP_212838.1; NC_001318.1.
DR RefSeq; WP_002656801.1; NC_001318.1.
DR PDB; 2KWL; NMR; -; A=1-80.
DR PDBsum; 2KWL; -.
DR AlphaFoldDB; O51647; -.
DR BMRB; O51647; -.
DR SMR; O51647; -.
DR STRING; 224326.BB_0704; -.
DR PaxDb; 224326-BB_0704; -.
DR EnsemblBacteria; AAC67041; AAC67041; BB_0704.
DR GeneID; 56567513; -.
DR KEGG; bbu:BB_0704; -.
DR PATRIC; fig|224326.49.peg.1095; -.
DR HOGENOM; CLU_108696_5_6_12; -.
DR OrthoDB; 9804551at2; -.
DR UniPathway; UPA00094; -.
DR EvolutionaryTrace; O51647; -.
DR Proteomes; UP000001807; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000036; F:acyl carrier activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR HAMAP; MF_01217; Acyl_carrier; 1.
DR InterPro; IPR003231; ACP.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR NCBIfam; TIGR00517; acyl_carrier; 1.
DR PANTHER; PTHR20863; ACYL CARRIER PROTEIN; 1.
DR PANTHER; PTHR20863:SF77; ACYL CARRIER PROTEIN; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Fatty acid biosynthesis; Fatty acid metabolism;
KW Lipid biosynthesis; Lipid metabolism; Phosphopantetheine; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..80
FT /note="Acyl carrier protein"
FT /id="PRO_0000180110"
FT DOMAIN 4..79
FT /note="Carrier"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 39
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT HELIX 3..18
FT /evidence="ECO:0007829|PDB:2KWL"
FT HELIX 22..24
FT /evidence="ECO:0007829|PDB:2KWL"
FT TURN 27..29
FT /evidence="ECO:0007829|PDB:2KWL"
FT HELIX 30..33
FT /evidence="ECO:0007829|PDB:2KWL"
FT STRAND 35..37
FT /evidence="ECO:0007829|PDB:2KWL"
FT HELIX 39..53
FT /evidence="ECO:0007829|PDB:2KWL"
FT TURN 57..60
FT /evidence="ECO:0007829|PDB:2KWL"
FT HELIX 61..64
FT /evidence="ECO:0007829|PDB:2KWL"
FT HELIX 68..79
FT /evidence="ECO:0007829|PDB:2KWL"
SQ SEQUENCE 80 AA; 9334 MW; 8B7AD6C944C26FAC CRC64;
MDNDEIFSKV RSIISEQLDK KEDEITTDSR FVEDLNADSL DIYELLYLLE EAFDDKIPEN
EANEFETVGD VVNFIKKRKG
//
