ID O51I1_HUMAN Reviewed; 314 AA.
AC Q9H343; B9EKW2; Q6IF33;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 24-JAN-2024, entry version 168.
DE RecName: Full=Olfactory receptor 51I1;
DE AltName: Full=Odorant receptor HOR5'beta11;
DE AltName: Full=Olfactory receptor OR11-39;
GN Name=OR51I1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA Felsenfeld G., Groudine M., Hardison R.;
RT "Comparative structural and functional analysis of the olfactory receptor
RT genes flanking the human and mouse beta-globin gene clusters.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51I1";
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DR EMBL; AF137396; AAG41679.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68794.1; -; Genomic_DNA.
DR EMBL; BC151148; AAI51149.1; -; mRNA.
DR EMBL; BK004429; DAA04827.1; -; Genomic_DNA.
DR CCDS; CCDS31382.1; -.
DR RefSeq; NP_001005288.1; NM_001005288.2.
DR AlphaFoldDB; Q9H343; -.
DR SMR; Q9H343; -.
DR STRING; 9606.ENSP00000369559; -.
DR BioMuta; OR51I1; -.
DR DMDM; 14423835; -.
DR PaxDb; 9606-ENSP00000369559; -.
DR PeptideAtlas; Q9H343; -.
DR Antibodypedia; 55456; 91 antibodies from 20 providers.
DR DNASU; 390063; -.
DR Ensembl; ENST00000380211.1; ENSP00000369559.1; ENSG00000167359.8.
DR GeneID; 390063; -.
DR KEGG; hsa:390063; -.
DR MANE-Select; ENST00000380211.1; ENSP00000369559.1; NM_001005288.3; NP_001005288.1.
DR UCSC; uc010qze.3; human.
DR AGR; HGNC:15200; -.
DR CTD; 390063; -.
DR DisGeNET; 390063; -.
DR GeneCards; OR51I1; -.
DR HGNC; HGNC:15200; OR51I1.
DR HPA; ENSG00000167359; Not detected.
DR neXtProt; NX_Q9H343; -.
DR PharmGKB; PA32380; -.
DR VEuPathDB; HostDB:ENSG00000167359; -.
DR eggNOG; ENOG502RF9W; Eukaryota.
DR GeneTree; ENSGT01090000259999; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q9H343; -.
DR OMA; TFCFNYH; -.
DR OrthoDB; 4578140at2759; -.
DR PhylomeDB; Q9H343; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q9H343; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390063; 10 hits in 755 CRISPR screens.
DR GeneWiki; OR51I1; -.
DR GenomeRNAi; 390063; -.
DR Pharos; Q9H343; Tdark.
DR PRO; PR:Q9H343; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H343; Protein.
DR Bgee; ENSG00000167359; Expressed in right uterine tube and 5 other cell types or tissues.
DR ExpressionAtlas; Q9H343; baseline and differential.
DR Genevisible; Q9H343; HS.
DR GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR CDD; cd15222; 7tmA_OR51-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26450:SF66; OLFACTORY RECEPTOR 51I1; 1.
DR PANTHER; PTHR26450; OLFACTORY RECEPTOR 56B1-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 51I1"
FT /id="PRO_0000150757"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 124
FT /note="R -> H (in dbSNP:rs16930982)"
FT /id="VAR_053328"
FT VARIANT 164
FT /note="V -> L (in dbSNP:rs11037445)"
FT /id="VAR_034320"
FT VARIANT 252
FT /note="A -> S (in dbSNP:rs1498486)"
FT /id="VAR_024142"
SQ SEQUENCE 314 AA; 35484 MW; 08B40AD79CB94911 CRC64;
MLGLNGTPFQ PATLQLTGIP GIQTGLTWVA LIFCILYMIS IVGNLSILTL VFWEPALHQP
MYYFLSMLAL NDLGVSFSTL PTVISTFCFN YNHVAFNACL VQMFFIHTFS FMESGILLAM
SLDRFVAICY PLRYVTVLTH NRILAMGLGI LTKSFTTLFP FPFVVKRLPF CKGNVLHHSY
CLHPDLMKVA CGDIHVNNIY GLLVIIFTYG MDSTFILLSY ALILRAMLVI ISQEQRLKAL
NTCMSHICAV LAFYVPIIAV SMIHRFWKSA PPVVHVMMSN VYLFVPPMLN PIIYSVKTKE
IRKGILKFFH KSQA
//
