ID O52H1_HUMAN Reviewed; 314 AA.
AC Q8NGJ2; B9EH26; Q6IF79;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2024, sequence version 4.
DT 27-MAR-2024, entry version 164.
DE RecName: Full=Olfactory receptor 52H1;
DE AltName: Full=Olfactory receptor OR11-45;
GN Name=OR52H1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52H1";
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DR EMBL; AB065802; BAC06021.1; -; Genomic_DNA.
DR EMBL; BC136998; AAI36999.1; -; mRNA.
DR EMBL; BK004383; DAA04781.1; -; Genomic_DNA.
DR RefSeq; NP_001005289.1; NM_001005289.1.
DR AlphaFoldDB; Q8NGJ2; -.
DR SMR; Q8NGJ2; -.
DR STRING; 9606.ENSP00000493308; -.
DR GlyCosmos; Q8NGJ2; 2 sites, No reported glycans.
DR GlyGen; Q8NGJ2; 2 sites.
DR iPTMnet; Q8NGJ2; -.
DR PhosphoSitePlus; Q8NGJ2; -.
DR BioMuta; OR52H1; -.
DR DMDM; 223590251; -.
DR PaxDb; 9606-ENSP00000326259; -.
DR PeptideAtlas; Q8NGJ2; -.
DR Antibodypedia; 66901; 81 antibodies from 17 providers.
DR DNASU; 390067; -.
DR Ensembl; ENST00000322653.7; ENSP00000326259.5; ENSG00000181616.10.
DR Ensembl; ENST00000641796.2; ENSP00000493308.2; ENSG00000181616.10.
DR GeneID; 390067; -.
DR KEGG; hsa:390067; -.
DR MANE-Select; ENST00000322653.7; ENSP00000326259.5; NM_001005289.5; NP_001005289.2.
DR UCSC; uc010qzh.2; human.
DR AGR; HGNC:15218; -.
DR CTD; 390067; -.
DR GeneCards; OR52H1; -.
DR HGNC; HGNC:15218; OR52H1.
DR HPA; ENSG00000181616; Not detected.
DR neXtProt; NX_Q8NGJ2; -.
DR OpenTargets; ENSG00000181616; -.
DR PharmGKB; PA32410; -.
DR VEuPathDB; HostDB:ENSG00000181616; -.
DR eggNOG; ENOG502QW9N; Eukaryota.
DR GeneTree; ENSGT01090000260043; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGJ2; -.
DR OrthoDB; 4578140at2759; -.
DR PhylomeDB; Q8NGJ2; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NGJ2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390067; 9 hits in 745 CRISPR screens.
DR GeneWiki; OR52H1; -.
DR GenomeRNAi; 390067; -.
DR Pharos; Q8NGJ2; Tdark.
DR PRO; PR:Q8NGJ2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGJ2; Protein.
DR Bgee; ENSG00000181616; Expressed in sural nerve and 4 other cell types or tissues.
DR ExpressionAtlas; Q8NGJ2; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR CDD; cd15221; 7tmA_OR52B-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26450:SF123; OLFACTORY RECEPTOR 52H1; 1.
DR PANTHER; PTHR26450; OLFACTORY RECEPTOR 56B1-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 52H1"
FT /id="PRO_0000150777"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..101
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..197
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..275
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 269
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 39
FT /note="V -> A (in dbSNP:rs56291963)"
FT /id="VAR_062083"
FT VARIANT 41
FT /note="V -> I (in dbSNP:rs2254076)"
FT /id="VAR_054361"
FT VARIANT 83
FT /note="A -> T (in dbSNP:rs10769054)"
FT /id="VAR_054362"
FT VARIANT 124
FT /note="H -> R (in dbSNP:rs1566275)"
FT /id="VAR_054363"
FT VARIANT 229
FT /note="G -> C (in dbSNP:rs1995157)"
FT /id="VAR_054364"
FT VARIANT 236
FT /note="C -> R (in dbSNP:rs1995158)"
FT /id="VAR_054365"
FT VARIANT 277
FT /note="M -> T (in dbSNP:rs7934354)"
FT /id="VAR_054366"
SQ SEQUENCE 314 AA; 35047 MW; 18AB1277AF15E2C1 CRC64;
MIIFNLSSYN PGPFILVGIP GLEQFHVWIG IPFCIIYIVA VVGNCILLYL IVVEHSLHEP
MFFFLSMLAM TDLILSTAGV PKALSIFWLG AREITFPGCL TQMFFLHYNF VLDSAILMAM
AFDHYVAICS PLRYTTILTP KTIIKSAMGI SFRSFCIILP DVFLLTCLPF CRTRIIPHTY
CEHIGVAQLA CADISINFWY GFCVPIMTVI SDVILIAVSY AHILCAVFGL PSQDACQKAL
GTCGSHVCVI LMFYTPAFFS ILAHRFGHNV SRTFHIMFAN LYIVIPPALN PMVYGVKTKQ
IRDKVILLFS KGTG
//
