ID MOEA2_MYCTU Reviewed; 405 AA.
AC O53725; L0T5D3;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 01-MAY-2013, entry version 80.
DE RecName: Full=Molybdopterin molybdenumtransferase 2;
DE Short=MPT Mo-transferase 2;
DE EC=2.10.1.1;
GN Name=moaE2; OrderedLocusNames=Rv0438c, MT0454; ORFNames=MTV037.02c;
OS Mycobacterium tuberculosis.
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
RA Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
RA Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
RA Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
RA Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
RA Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
RA Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the
RT complete genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H.,
RA Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D.,
RA Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M.,
RA Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C.,
RA Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
RN [3]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium
RT tuberculosis through an interactome, reactome and genome-scale
RT structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
CC -!- FUNCTION: Catalyzes the insertion of molybdate into adenylated
CC molybdopterin with the concomitant release of AMP (By similarity).
CC -!- CATALYTIC ACTIVITY: Adenylyl-molybdopterin + molybdate =
CC molybdenum cofactor + AMP.
CC -!- COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
CC -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC -!- SIMILARITY: Belongs to the MoeA family.
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DR EMBL; BX842573; CAE55280.1; -; Genomic_DNA.
DR EMBL; AE000516; AAK44677.1; -; Genomic_DNA.
DR EMBL; AL123456; CCP43169.1; -; Genomic_DNA.
DR PIR; G70829; G70829.
DR RefSeq; NP_334863.1; NC_002755.2.
DR RefSeq; YP_006513764.1; NC_018143.1.
DR RefSeq; YP_177725.1; NC_000962.3.
DR ProteinModelPortal; O53725; -.
DR SMR; O53725; 13-389.
DR STRING; 83332.Rv0438c; -.
DR PRIDE; O53725; -.
DR EnsemblBacteria; AAK44677; AAK44677; MT0454.
DR GeneID; 13318305; -.
DR GeneID; 886348; -.
DR GeneID; 923772; -.
DR KEGG; mtc:MT0454; -.
DR KEGG; mtu:Rv0438c; -.
DR KEGG; mtv:RVBD_0438c; -.
DR PATRIC; 18122708; VBIMycTub22151_0488.
DR TubercuList; Rv0438c; -.
DR eggNOG; COG0303; -.
DR HOGENOM; HOG000280651; -.
DR KO; K03750; -.
DR OMA; NPPQHAI; -.
DR ProtClustDB; CLSK799709; -.
DR UniPathway; UPA00344; -.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 2.40.340.10; -; 1.
DR Gene3D; 3.40.980.10; -; 1.
DR InterPro; IPR020817; Mo_cofactor_synthesis.
DR InterPro; IPR005111; MoeA_C_domain_IV.
DR InterPro; IPR005110; MoeA_linker/N.
DR InterPro; IPR001453; Mopterin-bd_dom.
DR Pfam; PF00994; MoCF_biosynth; 1.
DR Pfam; PF03454; MoeA_C; 1.
DR Pfam; PF03453; MoeA_N; 1.
DR SMART; SM00852; MoCF_biosynth; 1.
DR SUPFAM; SSF53218; MoCF_biosynth; 1.
DR SUPFAM; SSF63867; MoeA_C; 1.
DR SUPFAM; SSF63882; MoeA_N; 1.
DR TIGRFAMs; TIGR00177; molyb_syn; 1.
DR PROSITE; PS01079; MOCF_BIOSYNTHESIS_2; FALSE_NEG.
PE 3: Inferred from homology;
KW Complete proteome; Magnesium; Metal-binding; Molybdenum;
KW Molybdenum cofactor biosynthesis; Reference proteome; Transferase.
FT CHAIN 1 405 Molybdopterin molybdenumtransferase 2.
FT /FTId=PRO_0000170992.
SQ SEQUENCE 405 AA; 42021 MW; E21F6BA920EFD889 CRC64;
MRSVQEHQRV VAEMMRACRP ITVPLTQAQG LVLGGDVVAP LSLPVFDNSA MDGYAVRAED
TSGATPQNPV MLPVAEDIPA GRADMLTLQP VTAHRIMTGA PVPTGATAIV PVEATDGGVD
SVAIRQQATP GKHIRRSGED VAAGTTVLHN GQIVTPAVLG LAAALGLAEL PVLPRQRVLV
ISTGSELASP GTPLQPGQIY ESNSIMLAAA VRDAGAAVVA TATAGDDVAQ FGAILDRYAV
DADLIITSGG VSAGAYEVVK DAFGSADYRG GDHGVEFVKV AMQPGMPQGV GRVAGTPIVT
LPGNPVSALV SFEVFIRPPL RMAMGLPDPY RPHRSAVLTA SLTSPRGKRQ FRRAILDHQA
GTVISYGPPA SHHLRWLASA NGLLDIPEDV VEVAAGTQLQ VWDLT
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