ID O55415_9HEPC Unreviewed; 253 AA.
AC O55415;
DT 01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JUN-1998, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Polyprotein {ECO:0000313|EMBL:AAB88148.1};
DE Flags: Fragment;
OS Hepacivirus hominis.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC Amarillovirales; Flaviviridae; Hepacivirus.
OX NCBI_TaxID=3052230 {ECO:0000313|EMBL:AAB88148.1};
RN [1] {ECO:0000313|EMBL:AAB88148.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10201944;
RA Wang H., Eckels D.D.;
RT "Mutations in immunodominant T cell epitopes derived from the nonstructural
RT 3 protein of hepatitis C virus have the potential for generating escape
RT variants that may have important consequences for T cell recognition.";
RL J. Immunol. 162:4177-4183(1999).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; AF035130; AAB88148.1; -; Genomic_RNA.
DR MEROPS; S29.001; -.
DR euHCVdb; AF035130; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.820.10; RNA Helicase Chain A , domain 3; 1.
DR InterPro; IPR011492; Flavi_DEAD.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF07652; Flavi_DEAD; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT DOMAIN 64..241
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAB88148.1"
FT NON_TER 253
FT /evidence="ECO:0000313|EMBL:AAB88148.1"
SQ SEQUENCE 253 AA; 26812 MW; D388412EEE4BB8C7 CRC64;
KFLADGGCSG GAYDIIICDE CHSTDATSIL GIGTVLDQAE TAGARLVVLA TATPPGSVTV
SHPNIEEVAL STTGEITFYG KAIPLEVIKG GRHLIFCHPK KKCDELAAKL VALGINAAAY
YRGLDVSVVP TNGDVVVVST DALMTGFTGD FDSVIDCNTC VTQTVDFSLD PTFTIETTTL
PQDAVSRTQR RGRTGRGKPG IYRFVAPGER PSGMFDSSVL CECYDAGCAW YELMPAETTV
RLRAYMNTPG LPV
//
