ID O57092_9POXV Unreviewed; 316 AA.
AC O57092;
DT 01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JUN-1998, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Tumor necrosis factor receptor II homolog {ECO:0000313|EMBL:AAB94350.1};
GN Name=crmD {ECO:0000313|EMBL:AAB94350.1};
OS Ectromelia virus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=12643 {ECO:0000313|EMBL:AAB94350.1};
RN [1] {ECO:0000313|EMBL:AAB94350.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Munich-SF {ECO:0000313|EMBL:AAB94350.1};
RX PubMed=9520445; DOI=10.1073/pnas.95.7.3786;
RA Loparev V.N., Parsons J.M., Knight J.C., Panus J.F., Ray C.A., Buller R.M.,
RA Pickup D.J., Esposito J.J.;
RT "A third distinct tumor necrosis factor receptor of orthopoxviruses.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:3786-3791(1998).
CC -!- SIMILARITY: Belongs to the orthopoxvirus OPG002 family.
CC {ECO:0000256|ARBA:ARBA00034724}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; U87580; AAB94350.1; -; Genomic_DNA.
DR GO; GO:0005031; F:tumor necrosis factor receptor activity; IEA:InterPro.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:InterPro.
DR CDD; cd15839; TNFRSF_viral; 1.
DR Gene3D; 2.60.240.20; -; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR010806; Poxvirus_TNF-rcpt-II_C.
DR InterPro; IPR011172; Poxvirus_TNF_rcpt-II.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR034059; TNFRSF_N_viral.
DR PANTHER; PTHR47386; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B; 1.
DR PANTHER; PTHR47386:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B; 1.
DR Pfam; PF07190; CrmD_SECRET; 1.
DR Pfam; PF00020; TNFR_c6; 1.
DR PIRSF; PIRSF001790; TNF_C22L; 1.
DR SMART; SM00208; TNFR; 3.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Receptor {ECO:0000313|EMBL:AAB94350.1}.
FT REPEAT 26..60
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 26..60
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 62..103
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 62..103
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 39..52
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 42..60
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 63..78
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 85..103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 316 AA; 34660 MW; 443CC1185B4E12A9 CRC64;
MMKMTPSYIL LVVVSGDVPY TPINGKCNGT DYNSNNLCCK QCNPGMYMTH SCNTTSNTKC
DKCPDDTFTS IPNHSPACLS CRGKCSSNQV ETKSCSNTQD RVCVCASGYY CEFEGSNGCR
LCVPQTKCGS GYGVYGYSSK GDVICKKCPG NIDKCDLSFN SIDVEINMYP VNKTSCNSSI
GSSSTISTSE LTITLTHEDC TPVFIGDYYS VVDKLATSGF FTNDKVRQDL TTQCKINLEI
KCNSGRESRQ LTPTTKVYFM PHSETVTVVG DCLSNLDVYI VYANTDAIYS DMNVVAYHTS
YILNVDHIPP NDCERD
//
