ID O58378_PYRHO Unreviewed; 364 AA.
AC O58378;
DT 01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT 01-AUG-1998, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=THUMP domain-containing protein {ECO:0000259|PROSITE:PS51165};
GN OrderedLocusNames=PH0644 {ECO:0000313|EMBL:BAA29735.1};
OS Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS 100139 / OT-3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=70601 {ECO:0000313|EMBL:BAA29735.1, ECO:0000313|Proteomes:UP000000752};
RN [1] {ECO:0000313|EMBL:BAA29735.1, ECO:0000313|Proteomes:UP000000752}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3
RC {ECO:0000313|Proteomes:UP000000752};
RX PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA Otuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Nakamura Y.,
RA Robb T.F., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT "Complete sequence and gene organization of the genome of a hyper-
RT thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL DNA Res. 5:55-76(1998).
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DR EMBL; BA000001; BAA29735.1; -; Genomic_DNA.
DR PIR; E71109; E71109.
DR RefSeq; WP_010884742.1; NC_000961.1.
DR AlphaFoldDB; O58378; -.
DR STRING; 70601.gene:9377588; -.
DR EnsemblBacteria; BAA29735; BAA29735; BAA29735.
DR GeneID; 1442977; -.
DR KEGG; pho:PH0644; -.
DR eggNOG; arCOG00048; Archaea.
DR OrthoDB; 7080at2157; -.
DR Proteomes; UP000000752; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006400; P:tRNA modification; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR NCBIfam; NF040850; Trm14_Thcoccales; 1.
DR PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14911:SF22; TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SMART; SM00981; THUMP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF143437; THUMP domain-like; 1.
DR PROSITE; PS51165; THUMP; 1.
DR PROSITE; PS01261; UPF0020; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 67..180
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
SQ SEQUENCE 364 AA; 41298 MW; F8B4AFBAD96D5C8F CRC64;
MRLLLTTAQG IEDIAKKEIM ELLKENTVTI QEKPFNVEGR LLVEVKETFY TDEKGRKRPF
EFATYLNEKS KTLHRVIIEI ASHEFKGITE ENPEKALKRI EEFTVNIPVE RFIKVTESFA
VRAFRKGEHT ITSVDIARVV GKAIFDRLSR IGSPIVNLDH PSTIVRAELI NEAFFLGIDT
TGDHSLHRRP WRVYDHPAHL KASIANALIE LAEVEDGASF IDPFCGSGTI PIELALRGYQ
GRIICLEKFA KHLNGAKMNA LAAGVFDKIE FIKGDARRLS KYVDEVDFAV SNLPYGLKIG
RKSMIPSLYE RFFDELSKVL QKRGVFITTE KEAIEKAIEE VGFKITHYRI IGHGGLRVHT
YVIS
//
