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Database: UniProt
Entry: O59781
LinkDB: O59781
Original site: O59781 
ID   GEM1_SCHPO              Reviewed;         630 AA.
AC   O59781;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-APR-2014, entry version 92.
DE   RecName: Full=Mitochondrial Rho GTPase 1;
DE            EC=3.6.5.-;
DE   AltName: Full=GTPase EF-hand protein of mitochondria 1;
GN   Name=gem1; ORFNames=SPCC320.04c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Mitochondrial GTPase involved in mitochondrial
CC       trafficking. Probably involved in control of anterograde transport
CC       of mitochondria and their subcellular distribution (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass
CC       type IV membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the mitochondrial Rho GTPase family.
CC   -!- SIMILARITY: Contains 2 EF-hand domains.
CC   -!- SIMILARITY: Contains 2 Miro domains.
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DR   EMBL; CU329672; CAA18306.1; -; Genomic_DNA.
DR   PIR; T41307; T41307.
DR   RefSeq; NP_587725.1; NM_001022720.2.
DR   ProteinModelPortal; O59781; -.
DR   MINT; MINT-4676138; -.
DR   STRING; 4896.SPCC320.04c-1; -.
DR   EnsemblFungi; SPCC320.04c.1; SPCC320.04c.1:pep; SPCC320.04c.
DR   GeneID; 2538910; -.
DR   KEGG; spo:SPCC320.04c; -.
DR   PomBase; SPCC320.04c; -.
DR   eggNOG; COG1100; -.
DR   HOGENOM; HOG000215553; -.
DR   KO; K07870; -.
DR   OMA; REDHKSY; -.
DR   OrthoDB; EOG73545F; -.
DR   PhylomeDB; O59781; -.
DR   NextBio; 20800088; -.
DR   PRO; PR:O59781; -.
DR   GO; GO:0005829; C:cytosol; IDA:PomBase.
DR   GO; GO:0032865; C:ERMES complex; ISO:PomBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; IDA:PomBase.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; ISO:PomBase.
DR   GO; GO:0019725; P:cellular homeostasis; IEA:InterPro.
DR   GO; GO:0006184; P:GTP catabolic process; ISO:GOC.
DR   GO; GO:0007005; P:mitochondrion organization; ISO:PomBase.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.238.10; -; 2.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR013566; EF_hand_assoc_1.
DR   InterPro; IPR013567; EF_hand_assoc_2.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR020860; MIRO.
DR   InterPro; IPR013684; MIRO-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR021181; Rho_GTPase_Mt.
DR   InterPro; IPR001806; Small_GTPase.
DR   PANTHER; PTHR24072:SF69; PTHR24072:SF69; 1.
DR   Pfam; PF13405; EF-hand_6; 1.
DR   Pfam; PF08355; EF_assoc_1; 1.
DR   Pfam; PF08356; EF_assoc_2; 1.
DR   Pfam; PF08477; Miro; 2.
DR   PIRSF; PIRSF037488; Mt_Rho_GTPase; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS51423; MIRO; 2.
PE   3: Inferred from homology;
KW   Calcium; Complete proteome; GTP-binding; Hydrolase; Membrane;
KW   Metal-binding; Mitochondrion; Mitochondrion outer membrane;
KW   Nucleotide-binding; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    630       Mitochondrial Rho GTPase 1.
FT                                /FTId=PRO_0000239339.
FT   TOPO_DOM      1    598       Mitochondrial intermembrane (Potential).
FT   TRANSMEM    599    619       Helical; Anchor for type IV membrane
FT                                protein; (Potential).
FT   TOPO_DOM    620    630       Cytoplasmic (Potential).
FT   DOMAIN        1    155       Miro 1.
FT   DOMAIN      184    219       EF-hand 1.
FT   DOMAIN      304    339       EF-hand 2.
FT   DOMAIN      415    561       Miro 2.
FT   NP_BIND      10     17       GTP 1 (Potential).
FT   NP_BIND      57     61       GTP 1 (Potential).
FT   NP_BIND     113    116       GTP 1 (Potential).
FT   CA_BIND     197    208       1 (Potential).
FT   CA_BIND     317    328       2 (Potential).
FT   NP_BIND     428    435       GTP 2 (Potential).
FT   NP_BIND     459    463       GTP 2 (Potential).
FT   NP_BIND     527    530       GTP 2 (Potential).
SQ   SEQUENCE   630 AA;  71177 MW;  9B36A65260CA3919 CRC64;
     MKEVRVVICG DQGVGKSSLI SALIQEDNVT SIPKVFPIIS IPSNPDSNDD VSLVLVDTQS
     DSNEREYLAA EIKKANVICL VYSDNYSYER VSIFWLPYFR SLGVNVPIVL CENKSEDLDN
     YQGLHTIEHE MIPLINEFKE IEACILCSAL EKINVNELFY MCRACVIYPI TPLWDAKERT
     MRKATIHALS RIFFLIDKNN DDLLSVDELN SLSEKCFSKN LSIEDASEIL SKVKEICPEG
     VYEGQLTLPG FLAYNRVQVE NGKQESTWGI LRAFHYTDSL SLDDSYLSPK FEVAPGQIVE
     LSPKGYRFLV DLFYQFDRDN DGALNNEELS ALFRHTPGLP EIWVSSQFPN STVLNEHGYV
     TYNGWLAQWS MITLFDYKTT LAYLAYLGFD TDGRGHNTDA LKVMRKRVSQ NRKVSKYDRN
     VFLCFVVGSK SCGKTALLSS FINNNTNRLT PNTVVNSVEF QSTQRYLVLS EIGETDLDIL
     AEPKSLEACD ILCLLYDSSN PNSFSFIANL LNLYPDLQKI PCVFAATKAD LDRQQQRYPV
     QPDEFTKQLG LPSPTHISTA AIWNTSKEFF IQLAESAQYP ASSIIRIPEE DSNKTNYQLV
     AALTAFGALL LSVGGSLTWK IIKHQYYSKK
//
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