ID ILVBL_CAEEL Reviewed; 640 AA.
AC O61856;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 29-MAY-2013, entry version 81.
DE RecName: Full=Acetolactate synthase-like protein;
DE EC=2.2.1.-;
DE AltName: Full=IlvB-like protein;
GN ORFNames=T26C12.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for
RT investigating biology.";
RL Science 282:2012-2018(1998).
CC -!- COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
CC -!- COFACTOR: Binds 1 thiamine pyrophosphate per subunit (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
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DR EMBL; FO081749; CCD74004.1; -; Genomic_DNA.
DR PIR; T33164; T33164.
DR RefSeq; NP_500306.1; NM_067905.3.
DR UniGene; Cel.5694; -.
DR ProteinModelPortal; O61856; -.
DR SMR; O61856; 58-629.
DR IntAct; O61856; 1.
DR STRING; 6239.T26C12.1.2; -.
DR PaxDb; O61856; -.
DR EnsemblMetazoa; T26C12.1.1; T26C12.1.1; T26C12.1.
DR EnsemblMetazoa; T26C12.1.2; T26C12.1.2; T26C12.1.
DR GeneID; 177095; -.
DR KEGG; cel:CELE_T26C12.1; -.
DR UCSC; T26C12.1.1; c. elegans.
DR CTD; 177095; -.
DR WormBase; T26C12.1; CE26009; WBGene00020831; -.
DR eggNOG; COG0028; -.
DR GeneTree; ENSGT00530000063412; -.
DR HOGENOM; HOG000010642; -.
DR InParanoid; O61856; -.
DR KO; K11259; -.
DR OMA; TWNGKGA; -.
DR NextBio; 895312; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008152; P:metabolic process; IEA:GOC.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR011766; TPP_enzyme-bd_C.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Complete proteome; Magnesium; Membrane; Metal-binding;
KW Reference proteome; Thiamine pyrophosphate; Transferase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 640 Acetolactate synthase-like protein.
FT /FTId=PRO_0000314829.
FT TRANSMEM 2 22 Helical; (Potential).
FT REGION 477 557 Thiamine pyrophosphate binding (By
FT similarity).
FT METAL 528 528 Magnesium (By similarity).
FT METAL 554 554 Magnesium (By similarity).
FT BINDING 102 102 Thiamine pyrophosphate (By similarity).
SQ SEQUENCE 640 AA; 69263 MW; D5F793843BF923C8 CRC64;
MVLFLIIAAI IIGLLLWKWL DVRSTDELTS MVKLLGSGNG QHVLSNAFQV DEKSKRHGGE
LVASVLKAHD VEEIFVLCGG HISPILVAAE KLGIKIVDTR HEVTAVFAAD AVARLRQSIG
VAAVTAGPGL TNTITAVKNA QMAESPLLLI GGAAPTLLKG RGALQDIDQM VLFRPLCKYV
ARVERLRDIV PTVREAIKAA KSGCPGPVFV EFPVDVLYPY ELVVKEIGFN PNAKGFIQRA
LNFYLRCHVS RQFGNAWAPQ TITPLPTNIP MPKSEKIQEI VQLVKSAKRP VLLIGSQATL
PPVKPADLVK AVEALGCPVF LGGMARGLLG KDHPLQMRQV RRDALKDADL TILAGTVCDF
RLSYGRTLSK KSKIVALNRN SSQLTKNEKA FWNSDVSVQA DVATSLVQVA NALGANHTTT
PTEWVKSLRE KDDEKESANA KKMEQKLTNG FLNPLNFLRT LDQSLPDDAI LVADGGDFVG
SAAYIVRPRG PLQWLDPGAF GTLGVGGGFA LGAKTVYPKR PVYIIWGDGS CGYSLMEYDT
FARHKLPVIG IVGNDACWTQ IAREQVPMFQ SSVAVDLART RYDNVAKSLG SWGETIDESN
ADSARKILDE ALAVCRSGEQ SALVNVLIGK TDFREGSISV
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