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Database: UniProt
Entry: O61856
LinkDB: O61856
Original site: O61856 
ID   ILVBL_CAEEL             Reviewed;         640 AA.
AC   O61856;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 2.
DT   26-NOV-2014, entry version 89.
DE   RecName: Full=Acetolactate synthase-like protein;
DE            EC=2.2.1.-;
DE   AltName: Full=IlvB-like protein;
GN   ORFNames=T26C12.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000250};
CC       Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family. {ECO:0000305}.
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DR   EMBL; FO081749; CCD74004.1; -; Genomic_DNA.
DR   PIR; T33164; T33164.
DR   RefSeq; NP_500306.1; NM_067905.3.
DR   UniGene; Cel.5694; -.
DR   ProteinModelPortal; O61856; -.
DR   SMR; O61856; 58-629.
DR   IntAct; O61856; 1.
DR   STRING; 6239.T26C12.1.2; -.
DR   PaxDb; O61856; -.
DR   EnsemblMetazoa; T26C12.1; T26C12.1; WBGene00020831.
DR   GeneID; 177095; -.
DR   KEGG; cel:CELE_T26C12.1; -.
DR   UCSC; T26C12.1.1; c. elegans.
DR   CTD; 177095; -.
DR   WormBase; T26C12.1; CE26009; WBGene00020831; -.
DR   eggNOG; COG0028; -.
DR   GeneTree; ENSGT00530000063412; -.
DR   HOGENOM; HOG000010642; -.
DR   InParanoid; O61856; -.
DR   KO; K11259; -.
DR   OMA; WGRSTHL; -.
DR   OrthoDB; EOG75B84X; -.
DR   PhylomeDB; O61856; -.
DR   NextBio; 895312; -.
DR   PRO; PR:O61856; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1220; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 2.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Magnesium; Membrane; Metal-binding;
KW   Reference proteome; Thiamine pyrophosphate; Transferase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    640       Acetolactate synthase-like protein.
FT                                /FTId=PRO_0000314829.
FT   TRANSMEM      2     22       Helical. {ECO:0000255}.
FT   REGION      477    557       Thiamine pyrophosphate binding.
FT                                {ECO:0000250}.
FT   METAL       528    528       Magnesium. {ECO:0000250}.
FT   METAL       554    554       Magnesium. {ECO:0000250}.
FT   BINDING     102    102       Thiamine pyrophosphate. {ECO:0000250}.
SQ   SEQUENCE   640 AA;  69263 MW;  D5F793843BF923C8 CRC64;
     MVLFLIIAAI IIGLLLWKWL DVRSTDELTS MVKLLGSGNG QHVLSNAFQV DEKSKRHGGE
     LVASVLKAHD VEEIFVLCGG HISPILVAAE KLGIKIVDTR HEVTAVFAAD AVARLRQSIG
     VAAVTAGPGL TNTITAVKNA QMAESPLLLI GGAAPTLLKG RGALQDIDQM VLFRPLCKYV
     ARVERLRDIV PTVREAIKAA KSGCPGPVFV EFPVDVLYPY ELVVKEIGFN PNAKGFIQRA
     LNFYLRCHVS RQFGNAWAPQ TITPLPTNIP MPKSEKIQEI VQLVKSAKRP VLLIGSQATL
     PPVKPADLVK AVEALGCPVF LGGMARGLLG KDHPLQMRQV RRDALKDADL TILAGTVCDF
     RLSYGRTLSK KSKIVALNRN SSQLTKNEKA FWNSDVSVQA DVATSLVQVA NALGANHTTT
     PTEWVKSLRE KDDEKESANA KKMEQKLTNG FLNPLNFLRT LDQSLPDDAI LVADGGDFVG
     SAAYIVRPRG PLQWLDPGAF GTLGVGGGFA LGAKTVYPKR PVYIIWGDGS CGYSLMEYDT
     FARHKLPVIG IVGNDACWTQ IAREQVPMFQ SSVAVDLART RYDNVAKSLG SWGETIDESN
     ADSARKILDE ALAVCRSGEQ SALVNVLIGK TDFREGSISV
//
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