ID O66825_AQUAE Unreviewed; 197 AA.
AC O66825;
DT 01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT 01-AUG-1998, sequence version 1.
DT 27-MAR-2024, entry version 134.
DE SubName: Full=Anthranilate synthase component II {ECO:0000313|EMBL:AAC06781.1};
GN Name=trpG {ECO:0000313|EMBL:AAC06781.1};
GN OrderedLocusNames=aq_549 {ECO:0000313|EMBL:AAC06781.1};
OS Aquifex aeolicus (strain VF5).
OC Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX NCBI_TaxID=224324 {ECO:0000313|EMBL:AAC06781.1, ECO:0000313|Proteomes:UP000000798};
RN [1] {ECO:0000313|EMBL:AAC06781.1, ECO:0000313|Proteomes:UP000000798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5 {ECO:0000313|EMBL:AAC06781.1,
RC ECO:0000313|Proteomes:UP000000798};
RX PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olson G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL Nature 392:353-358(1998).
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DR EMBL; AE000657; AAC06781.1; -; Genomic_DNA.
DR PIR; E70349; E70349.
DR RefSeq; NP_213385.1; NC_000918.1.
DR RefSeq; WP_010880323.1; NC_000918.1.
DR AlphaFoldDB; O66825; -.
DR STRING; 224324.aq_549; -.
DR MEROPS; C26.955; -.
DR EnsemblBacteria; AAC06781; AAC06781; aq_549.
DR KEGG; aae:aq_549; -.
DR PATRIC; fig|224324.8.peg.451; -.
DR eggNOG; COG0512; Bacteria.
DR HOGENOM; CLU_014340_1_2_0; -.
DR InParanoid; O66825; -.
DR OrthoDB; 9804328at2; -.
DR Proteomes; UP000000798; Chromosome.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IBA:GO_Central.
DR CDD; cd01743; GATase1_Anthranilate_Synthase; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR017926; GATASE.
DR InterPro; IPR006221; TrpG/PapA_dom.
DR NCBIfam; TIGR00566; trpG_papA; 1.
DR PANTHER; PTHR43418:SF4; MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR PANTHER; PTHR43418; MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED; 1.
DR Pfam; PF00117; GATase; 1.
DR PRINTS; PR00097; ANTSNTHASEII.
DR PRINTS; PR00099; CPSGATASE.
DR PRINTS; PR00096; GATASE.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 4: Predicted;
KW Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605};
KW Reference proteome {ECO:0000313|Proteomes:UP000000798}.
FT DOMAIN 4..186
FT /note="Glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF00117"
FT ACT_SITE 80
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 171
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 197 AA; 22365 MW; 7A8894FE244D45A0 CRC64;
MKVLMIDNYD SFTYNLVQYL GSLGADVIVR RNDQIRLEEV REINPDAIVI SPGPCTPKEA
GISVPLIKTY YKEYPILGVC LGHQSIGYAF GAKIVRAKRL MHGKTSQIFH TGEGVFKNLP
SPFTAVRYHS LVIDKNTLPE ELKITAWSDD EEIMGIEHKE YPVYGVQFHP ESVLSEHGME
ILKNFLELAE ERKLVKK
//
