ID CRMB_CWPXG Reviewed; 351 AA.
AC O73559; P87602;
DT 02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-APR-2013, entry version 59.
DE RecName: Full=Soluble TNF receptor II;
DE AltName: Full=Cytokine response-modifying protein B;
DE Flags: Precursor;
GN Name=CRMB1; ORFNames=D2L;
GN and
GN Name=CRMB2; ORFNames=I4R;
OS Cowpox virus (strain GRI-90 / Grishak) (CPV).
OC Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae;
OC Orthopoxvirus.
OX NCBI_TaxID=265871;
OH NCBI_TaxID=9913; Bos taurus (Bovine).
OH NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH NCBI_TaxID=10090; Mus musculus (Mouse).
OH NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=GRI-90 / Grishak;
RX PubMed=9568042; DOI=10.1006/viro.1998.9039;
RA Shchelkunov S.N., Safronov P.F., Totmenin A.V., Petrov N.A.,
RA Ryazankina O.I., Gutorov V.V., Kotwal G.J.;
RT "The genomic sequence analysis of the left and right species-specific
RT terminal region of a cowpox virus strain reveals unique sequences and
RT a cluster of intact ORFs for immunomodulatory and host range
RT proteins.";
RL Virology 243:432-460(1998).
RN [2]
RP FUNCTION.
RC STRAIN=Brighton red;
RX PubMed=8091665; DOI=10.1006/viro.1994.1539;
RA Hu F.Q., Smith C.A., Pickup D.J.;
RT "Cowpox virus contains two copies of an early gene encoding a soluble
RT secreted form of the type II TNF receptor.";
RL Virology 204:343-356(1994).
CC -!- FUNCTION: Receptor for TNF-alpha and TNF-beta. May contribute to
CC the modification of TNF-mediated antiviral processes.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Contains 2 TNFR-Cys repeats.
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DR EMBL; X94355; CAA64087.2; -; Genomic_DNA.
DR EMBL; X94355; CAD90756.1; -; Genomic_DNA.
DR ProteinModelPortal; O73559; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005031; F:tumor necrosis factor-activated receptor activity; IEA:InterPro.
DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:InterPro.
DR InterPro; IPR010806; Poxvirus_TNF-rcpt-II_C.
DR InterPro; IPR011172; Poxvirus_TNF_rcpt-II.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR Pfam; PF07190; DUF1406; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PIRSF; PIRSF001790; TNF_C22L; 1.
DR SMART; SM00208; TNFR; 3.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Disulfide bond; Glycoprotein; Receptor; Repeat; Secreted; Signal.
FT SIGNAL 1 19 Potential.
FT CHAIN 20 351 Soluble TNF receptor II.
FT /FTId=PRO_0000034618.
FT REPEAT 31 67 TNFR-Cys 1.
FT REPEAT 69 110 TNFR-Cys 2.
FT CARBOHYD 103 103 N-linked (GlcNAc...); by host
FT (Potential).
FT CARBOHYD 191 191 N-linked (GlcNAc...); by host
FT (Potential).
FT CARBOHYD 250 250 N-linked (GlcNAc...); by host
FT (Potential).
FT DISULFID 32 43 By similarity.
FT DISULFID 44 57 By similarity.
FT DISULFID 47 67 By similarity.
FT DISULFID 70 85 By similarity.
FT DISULFID 88 102 By similarity.
FT DISULFID 92 110 By similarity.
SQ SEQUENCE 351 AA; 38254 MW; 57CAE73EF4E5D7C7 CRC64;
MKSVLYSYIL FLSCIIINGR DIAPHAPSNG KCKDNEYNRH NLCCLSCPPG TYASRLCDSK
TNTNTQCTPC GSGTFTSRNN HLPACLSCNG RCDSNQVETR SCNTTHNRIC ECAPGYYCLL
KGSSGCKACV SQTKCGIGYG VSGHTSTGDV VCSPCGLGTY SHTVSSADKC EPVPSNTFNY
IDVEINLYPV NDTSCTRTTT TGLSESISTS ELTITMNHKD CDPVFRDGYF SVLNKVATSG
FFTGENRYQN ISKVCTLNFE IKCNNKDSSS KQLTKTKNDD GIMPHSETVT LVGDCLSSVD
IYILYSNTNT QDYETDTISY HVGNVLDVDS HMPGSCDIHK LITNSKPTRF L
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