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Database: UniProt
Entry: O73559
LinkDB: O73559
Original site: O73559 
ID   CRMB_CWPXG              Reviewed;         351 AA.
AC   O73559; P87602;
DT   02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   01-OCT-2014, entry version 62.
DE   RecName: Full=Soluble TNF receptor II;
DE   AltName: Full=Cytokine response-modifying protein B;
DE   Flags: Precursor;
GN   Name=CRMB1; ORFNames=D2L;
GN   and
GN   Name=CRMB2; ORFNames=I4R;
OS   Cowpox virus (strain GRI-90 / Grishak) (CPV).
OC   Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae;
OC   Orthopoxvirus.
OX   NCBI_TaxID=265871;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH   NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
OH   NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GRI-90 / Grishak;
RX   PubMed=9568042; DOI=10.1006/viro.1998.9039;
RA   Shchelkunov S.N., Safronov P.F., Totmenin A.V., Petrov N.A.,
RA   Ryazankina O.I., Gutorov V.V., Kotwal G.J.;
RT   "The genomic sequence analysis of the left and right species-specific
RT   terminal region of a cowpox virus strain reveals unique sequences and
RT   a cluster of intact ORFs for immunomodulatory and host range
RT   proteins.";
RL   Virology 243:432-460(1998).
RN   [2]
RP   FUNCTION.
RC   STRAIN=Brighton red;
RX   PubMed=8091665; DOI=10.1006/viro.1994.1539;
RA   Hu F.Q., Smith C.A., Pickup D.J.;
RT   "Cowpox virus contains two copies of an early gene encoding a soluble
RT   secreted form of the type II TNF receptor.";
RL   Virology 204:343-356(1994).
CC   -!- FUNCTION: Receptor for TNF-alpha and TNF-beta. May contribute to
CC       the modification of TNF-mediated antiviral processes.
CC       {ECO:0000269|PubMed:8091665}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Contains 2 TNFR-Cys repeats. {ECO:0000255|PROSITE-
CC       ProRule:PRU00206}.
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DR   EMBL; X94355; CAA64087.2; -; Genomic_DNA.
DR   EMBL; X94355; CAD90756.1; -; Genomic_DNA.
DR   ProteinModelPortal; O73559; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005031; F:tumor necrosis factor-activated receptor activity; IEA:InterPro.
DR   GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:InterPro.
DR   InterPro; IPR010806; Poxvirus_TNF-rcpt-II_C.
DR   InterPro; IPR011172; Poxvirus_TNF_rcpt-II.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   Pfam; PF07190; DUF1406; 1.
DR   Pfam; PF00020; TNFR_c6; 2.
DR   PIRSF; PIRSF001790; TNF_C22L; 1.
DR   SMART; SM00208; TNFR; 3.
DR   PROSITE; PS00652; TNFR_NGFR_1; 2.
DR   PROSITE; PS50050; TNFR_NGFR_2; 2.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Receptor; Repeat; Secreted; Signal.
FT   SIGNAL        1     19       {ECO:0000255}.
FT   CHAIN        20    351       Soluble TNF receptor II.
FT                                /FTId=PRO_0000034618.
FT   REPEAT       31     67       TNFR-Cys 1.
FT   REPEAT       69    110       TNFR-Cys 2.
FT   CARBOHYD    103    103       N-linked (GlcNAc...); by host.
FT                                {ECO:0000255}.
FT   CARBOHYD    191    191       N-linked (GlcNAc...); by host.
FT                                {ECO:0000255}.
FT   CARBOHYD    250    250       N-linked (GlcNAc...); by host.
FT                                {ECO:0000255}.
FT   DISULFID     32     43       {ECO:0000255|PROSITE-ProRule:PRU00206}.
FT   DISULFID     44     57       {ECO:0000255|PROSITE-ProRule:PRU00206}.
FT   DISULFID     47     67       {ECO:0000255|PROSITE-ProRule:PRU00206}.
FT   DISULFID     70     85       {ECO:0000255|PROSITE-ProRule:PRU00206}.
FT   DISULFID     88    102       {ECO:0000255|PROSITE-ProRule:PRU00206}.
FT   DISULFID     92    110       {ECO:0000255|PROSITE-ProRule:PRU00206}.
SQ   SEQUENCE   351 AA;  38254 MW;  57CAE73EF4E5D7C7 CRC64;
     MKSVLYSYIL FLSCIIINGR DIAPHAPSNG KCKDNEYNRH NLCCLSCPPG TYASRLCDSK
     TNTNTQCTPC GSGTFTSRNN HLPACLSCNG RCDSNQVETR SCNTTHNRIC ECAPGYYCLL
     KGSSGCKACV SQTKCGIGYG VSGHTSTGDV VCSPCGLGTY SHTVSSADKC EPVPSNTFNY
     IDVEINLYPV NDTSCTRTTT TGLSESISTS ELTITMNHKD CDPVFRDGYF SVLNKVATSG
     FFTGENRYQN ISKVCTLNFE IKCNNKDSSS KQLTKTKNDD GIMPHSETVT LVGDCLSSVD
     IYILYSNTNT QDYETDTISY HVGNVLDVDS HMPGSCDIHK LITNSKPTRF L
//
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