ID   O73749_XENLA            Unreviewed;      1219 AA.
AC   O73749;
DT   01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT   01-AUG-1998, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   SubName: Full=Nucleoporin Nup153 homolog {ECO:0000313|EMBL:AAC41273.1};
DE   Flags: Fragment;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:AAC41273.1};
RN   [1] {ECO:0000313|EMBL:AAC41273.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9531546; DOI=10.1083/jcb.141.1.31;
RA   Shah S., Tugendreich S., Forbes D.;
RT   "Major binding sites for the nuclear import receptor are the internal
RT   nucleoporin Nup153 and the adjacent nuclear filament protein Tpr.";
RL   J. Cell Biol. 141:31-49(1998).
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DR   EMBL; AF045567; AAC41273.1; -; mRNA.
DR   PIR; T14578; T14578.
DR   AlphaFoldDB; O73749; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 4.
DR   InterPro; IPR026054; Nucleoporin.
DR   InterPro; IPR013913; Nup153_N.
DR   InterPro; IPR001876; Znf_RanBP2.
DR   InterPro; IPR036443; Znf_RanBP2_sf.
DR   PANTHER; PTHR23193; NUCLEAR PORE COMPLEX PROTEIN NUP; 1.
DR   PANTHER; PTHR23193:SF23; NUCLEAR PORE COMPLEX PROTEIN NUP153; 1.
DR   Pfam; PF08604; Nup153; 1.
DR   Pfam; PF00641; zf-RanBP; 5.
DR   SMART; SM00547; ZnF_RBZ; 5.
DR   SUPFAM; SSF90209; Ran binding protein zinc finger-like; 4.
DR   PROSITE; PS01358; ZF_RANBP2_1; 5.
DR   PROSITE; PS50199; ZF_RANBP2_2; 5.
PE   2: Evidence at transcript level;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT   DOMAIN          269..298
FT                   /note="RanBP2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50199"
FT   DOMAIN          334..363
FT                   /note="RanBP2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50199"
FT   DOMAIN          404..433
FT                   /note="RanBP2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50199"
FT   DOMAIN          456..485
FT                   /note="RanBP2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50199"
FT   DOMAIN          520..549
FT                   /note="RanBP2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50199"
FT   REGION          1..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1109..1142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1170..1189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1195..1219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..323
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1109..1139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1195..1210
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAC41273.1"
SQ   SEQUENCE   1219 AA;  123248 MW;  24EB9F96683696F6 CRC64;
     ANRSLYIKPS LTPSAVSNTN SRRIQPDKHN ESTKNNLQST SQSHSFSYPK FSTPASNGLS
     SGTGGGKMMR EKGSHYSTKP ANEELDGPVL PEIPLPLSTA ALPSFQFSTL SGSATSPISV
     TKPANSTTCH LTSSSPSFTF SSPIVKSTES NAQFSGSSVD FTFSVPAAKA SSATSDESKV
     SAVSSAAKTH AAVNSSAKNT DDEQVGFCKP AKTLKEGSVL DMLRSPGFSS LPSLLTSEST
     LNRSTPTLSK TVGNTFSPAN VSLGVGSKQF GLWQCSACFH ENMSSDSNCI SCSAVKPRPT
     ETSKKLPASP PSSNTKSTVP LSSTPGLGDI FKKPAGMWDC DTCLVQNKAE VTKCVACETP
     KPGTCIKATL LIPSTTKSIN PATNTLAFAS CSASIPNEEM FKKPMGSWEC TVCHMQNKTE
     DNTCVGCKAE KPGTVKSVPT AAPSGLLGLL HQFKKPTGSW DCDVCLIQNK PEAAKCIACE
     SAKPGTKAEP KGTFDTVKNS VSVAPLSSGQ LGLLDQFKKS AGSWDCDVCL VENKPEATKC
     VACETSKPGT KAELKGFGTS TFSSGTAAPT FKFGVQSSDS TAELKSGAST SGFAKSIGDF
     KFGLVSASTT TEETGKKSFT FGSSTTNEVS AGFKFGIAGS AQTKPDTLSQ STTSGFTFGS
     VSNTVSLAPA ATSSSSTGLQ VAAAIADSNL ATTAALKSAE EKKAEAPTIT PFSFGKTDQN
     KETASTSFVF GKKDEKTDSA PTGSSFAFGL KKDGEESKPF LFGKPEPTKV DGNAASAGFA
     FGVTNPTEKK DIEQPGKSVF AFGAQTSITD AGASKQPFSF LTNVSSTAAS SSTCGVSSSV
     FGSVTQSSTP ATPSNVFGSA ISANAPAPSS GVFGNLTPSN APAASSTLFG NVAPSSTPSG
     SSGLFGTAAA SSTPATSTSL FGSAAKSSAP ASSGGVFNSA APAAPASTTS SVFGSVASST
     NTSANSANIF GSSGGAATAP GAFVFGQPAS TASTVFGNSS ESKSTFVFSG QENKPVTSAS
     TSVTPFLFGA VSATTTPAAP SFNFGRTITS NTTGTSSSPF IFGAGASGSA SSSITAQANP
     VPAFGQSSNP STAPAFGSST SVPVFPAGSS QQVPAFGSSS AQPPVFGQQA AQPSFGSPAA
     PSAGSGFPFG NNANFNFNST NSSGGVFTFN ANSGSTTQPP PPGYMFNAAA PGFNIGTNGR
     TTPASTISTR KIKTARRRK
//