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Database: UniProt
Entry: O74397
LinkDB: O74397
Original site: O74397 
ID   ASND1_SCHPO             Reviewed;         548 AA.
AC   O74397;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   29-OCT-2014, entry version 71.
DE   RecName: Full=Asparagine synthetase domain-containing protein C4F6.11c;
GN   ORFNames=SPBC4F6.11c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the
RT   fission yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC       Nucleus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Contains 1 asparagine synthetase domain.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 glutamine amidotransferase type-2 domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00609}.
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DR   EMBL; CU329671; CAA20731.1; -; Genomic_DNA.
DR   PIR; T40508; T40508.
DR   RefSeq; NP_596111.1; NM_001022028.2.
DR   ProteinModelPortal; O74397; -.
DR   BioGrid; 277384; 1.
DR   MINT; MINT-4678739; -.
DR   STRING; 4896.SPBC4F6.11c-1; -.
DR   MaxQB; O74397; -.
DR   EnsemblFungi; SPBC4F6.11c.1; SPBC4F6.11c.1:pep; SPBC4F6.11c.
DR   GeneID; 2540867; -.
DR   KEGG; spo:SPBC4F6.11c; -.
DR   PomBase; SPBC4F6.11c; -.
DR   eggNOG; COG0367; -.
DR   HOGENOM; HOG000038438; -.
DR   InParanoid; O74397; -.
DR   OMA; FLWNGEI; -.
DR   OrthoDB; EOG7TN04K; -.
DR   PhylomeDB; O74397; -.
DR   NextBio; 20801983; -.
DR   PRO; PR:O74397; -.
DR   GO; GO:0005829; C:cytosol; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; IDA:PomBase.
DR   GO; GO:0004066; F:asparagine synthase (glutamine-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0006529; P:asparagine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006531; P:aspartate metabolic process; NAS:PomBase.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.620; -; 1.
DR   Gene3D; 3.60.20.10; -; 1.
DR   InterPro; IPR001962; Asn_synthase.
DR   InterPro; IPR017932; GATase_2_dom.
DR   InterPro; IPR000583; GATase_dom.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   Pfam; PF00733; Asn_synthase; 1.
DR   Pfam; PF13537; GATase_7; 1.
DR   SUPFAM; SSF56235; SSF56235; 1.
DR   PROSITE; PS51278; GATASE_TYPE_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Asparagine biosynthesis; Complete proteome;
KW   Cytoplasm; Glutamine amidotransferase; Nucleus; Reference proteome.
FT   INIT_MET      1      1       Removed. {ECO:0000250}.
FT   CHAIN         2    548       Asparagine synthetase domain-containing
FT                                protein C4F6.11c.
FT                                /FTId=PRO_0000314119.
FT   DOMAIN        2    193       Glutamine amidotransferase type-2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00609}.
FT   DOMAIN      239    519       Asparagine synthetase.
FT   ACT_SITE      2      2       Nucleophile. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00609}.
SQ   SEQUENCE   548 AA;  62006 MW;  C0C6DB4EA5FF39DD CRC64;
     MCGILFALAE DRDNLLESPS FSALRKRIRA RGPDFFGKHK LNSGPWNLHF ESSVLHLRGP
     SDHLTPQPHV DSFGNVLCWN GEIWQINHSD HHKFTLNRNE NDGAKLFELL NNNPGDIEKI
     LGSIQGPFAF VYYQVRTNTL WWGRDRLGRR SLLYSLRDSN FVLSSVGNSS DFREVEPGFH
     SVQVDLIPKI NFSKSLMQLE KTNPLPPVDE SFLMGSISSD TVDTLHTYLI KALQDRVLTI
     PKLCSSNLDC SHYSRVCVLY SGGVDCGVLA RLMHDIVPNN ESIDLINVAF ENPRFTETYR
     DRETGLLPDN FDAYDVCPDR QTGLQGWQEL ISVCPARKWN FVAINVPYTE VCEAQEIVKT
     LIYPNDSVMD LSIGLAFYFA SQGRGVLLQN VDDIKLKHQL PSYTIKAKVL ISGLGADEQL
     GGYMRHLRAF ERKGMAGLEE ELQLDIDRIP HRNLGRDDRV MSNQGKEVRY PFLDERLMAL
     FSKMKTTDKM RLDLVGGDKL ILRELGRRLG CPLASQEKKR AIQFGSKAAK MTPGTGRTSG
     RKKLEVCI
//
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