ID MSHR_CANFA Reviewed; 317 AA.
AC O77616;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 2.
DT 03-APR-2013, entry version 89.
DE RecName: Full=Melanocyte-stimulating hormone receptor;
DE Short=MSH-R;
DE AltName: Full=Melanocortin receptor 1;
DE Short=MC1-R;
GN Name=MC1R;
OS Canis familiaris (Dog) (Canis lupus familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT 306-ARG--TRP-317 DEL.
RX PubMed=10895310; DOI=10.1046/j.1365-2052.2000.00639.x;
RA Everts R.E., Rothuizen J., van Oost B.A.;
RT "Identification of a premature stop codon in the melanocyte-
RT stimulating hormone receptor gene (MC1R) in Labrador and Golden
RT retrievers with yellow coat colour.";
RL Anim. Genet. 31:194-199(2000).
CC -!- FUNCTION: Receptor for MSH (alpha, beta) and ACTH. Does not seem
CC to be active with gamma-MSH. The activity of this receptor is
CC mediated by G proteins which activate adenylate cyclase. Could be
CC involved in spermatogenesis.
CC -!- SUBUNIT: Interacts with MGRN1, but does not undergo MGRN1-mediated
CC ubiquitination; this interaction competes with GNAS-binding and
CC thus inhibits agonist-induced cAMP production (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
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DR EMBL; AF064455; AAC33737.2; -; Genomic_DNA.
DR RefSeq; NP_001014304.1; NM_001014282.1.
DR UniGene; Cfa.23471; -.
DR ProteinModelPortal; O77616; -.
DR STRING; 9615.ENSCAFP00000032431; -.
DR GeneID; 489652; -.
DR KEGG; cfa:489652; -.
DR CTD; 4157; -.
DR eggNOG; NOG295510; -.
DR HOGENOM; HOG000246927; -.
DR HOVERGEN; HBG108148; -.
DR InParanoid; O77616; -.
DR KO; K04199; -.
DR OrthoDB; EOG4ZPDW6; -.
DR NextBio; 20862804; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004980; F:melanocyte-stimulating hormone receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001671; Melcrt_ACTH_rcpt.
DR InterPro; IPR000761; MSH_rcpt.
DR PANTHER; PTHR22750:SF2; PTHR22750:SF2; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00534; MCRFAMILY.
DR PRINTS; PR00536; MELNOCYTESHR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; G-protein coupled receptor;
KW Glycoprotein; Lipoprotein; Membrane; Palmitate; Polymorphism;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 317 Melanocyte-stimulating hormone receptor.
FT /FTId=PRO_0000069798.
FT TOPO_DOM 1 37 Extracellular (Potential).
FT TRANSMEM 38 63 Helical; Name=1; (Potential).
FT TOPO_DOM 64 72 Cytoplasmic (Potential).
FT TRANSMEM 73 93 Helical; Name=2; (Potential).
FT TOPO_DOM 94 118 Extracellular (Potential).
FT TRANSMEM 119 140 Helical; Name=3; (Potential).
FT TOPO_DOM 141 163 Cytoplasmic (Potential).
FT TRANSMEM 164 183 Helical; Name=4; (Potential).
FT TOPO_DOM 184 191 Extracellular (Potential).
FT TRANSMEM 192 211 Helical; Name=5; (Potential).
FT TOPO_DOM 212 240 Cytoplasmic (Potential).
FT TRANSMEM 241 266 Helical; Name=6; (Potential).
FT TOPO_DOM 267 279 Extracellular (Potential).
FT TRANSMEM 280 300 Helical; Name=7; (Potential).
FT TOPO_DOM 301 317 Cytoplasmic (Potential).
FT LIPID 315 315 S-palmitoyl cysteine (Potential).
FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 29 29 N-linked (GlcNAc...) (Potential).
FT VARIANT 306 317 Missing (in Labrador and Golden retriever
FT with yellow coat color).
SQ SEQUENCE 317 AA; 34984 MW; F10FDD9552BEF922 CRC64;
MVWQGPQRRL LGSLNGTSPA TPHFELAANQ TGPRCLEVSI PNGLFLSLGL VSVVENVLVV
AAIAKNRNLH SPMYYFIGCL AVSDLLVSVT NVLETAVMLL VEAGALAAQA AVVQQLDDII
DVLICGSMVS SLCFLGAIAV DRYLSIFYAL RYHSIVTLPR AWRAISAIWV ASVLSSTLFI
AYYNHTAVLL CLVSFFVAML VLMAVLYVHM LARARQHARG IARLRKRQHS VHQGFGLKGA
ATLTILLGIF FLCWGPFFLH LSLMVLCPQH PICGCVFQNF NLFLTLIICN SIIDPFIYAF
RSQELRKTLQ EVVLCSW
//
