GenomeNet

Database: UniProt
Entry: O80433
LinkDB: O80433
Original site: O80433 
ID   CISY_DAUCA              Reviewed;         472 AA.
AC   O80433;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   01-OCT-2014, entry version 76.
DE   RecName: Full=Citrate synthase, mitochondrial;
DE            EC=2.3.3.16;
DE   Flags: Precursor;
GN   Name=CS;
OS   Daucus carota (Wild carrot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; asterids; campanulids; Apiales; Apiaceae; Apioideae;
OC   Scandiceae; Daucinae; Daucus.
OX   NCBI_TaxID=4039;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. MS Yonsun;
RA   Takita E., Koyama H., Shirano Y., Shibata D., Hara T.;
RT   "cDNA encoding carrot mitochondrial citrate synthase.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + H(2)O + oxaloacetate = citrate +
CC       CoA. {ECO:0000255|PROSITE-ProRule:PRU10117}.
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       isocitrate from oxaloacetate: step 1/2.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix.
CC   -!- MISCELLANEOUS: Citrate synthase is found in nearly all cells
CC       capable of oxidative metabolism.
CC   -!- SIMILARITY: Belongs to the citrate synthase family. {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AB017159; BAA32557.1; -; mRNA.
DR   ProteinModelPortal; O80433; -.
DR   SMR; O80433; 36-464.
DR   PRIDE; O80433; -.
DR   BioCyc; MetaCyc:MONOMER-15824; -.
DR   BRENDA; 2.3.3.1; 1841.
DR   UniPathway; UPA00223; UER00717.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR   GO; GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.580.10; -; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR002020; Citrate_synthase-like.
DR   InterPro; IPR016141; Citrate_synthase-like_core.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   InterPro; IPR010109; Citrate_synthase_euk.
DR   PANTHER; PTHR11739; PTHR11739; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; SSF48256; 1.
DR   TIGRFAMs; TIGR01793; cit_synth_euk; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Transferase; Transit peptide; Tricarboxylic acid cycle.
FT   TRANSIT       1      ?       Mitochondrion. {ECO:0000255}.
FT   CHAIN         ?    472       Citrate synthase, mitochondrial.
FT                                /FTId=PRO_0000005487.
FT   ACT_SITE    308    308       {ECO:0000255|PROSITE-ProRule:PRU10117}.
FT   ACT_SITE    354    354       {ECO:0000255|PROSITE-ProRule:PRU10117}.
FT   ACT_SITE    409    409       {ECO:0000255|PROSITE-ProRule:PRU10117}.
SQ   SEQUENCE   472 AA;  52657 MW;  A6C8CFCA17142120 CRC64;
     MVFFRSVSLL NKLRSRAVQQ SNLSNTVRWF QVQTSASDLD LRSQLKELIP EQQERIKKLK
     AEHGKVQLGN ITVDMVLGGM RGMTGLLWET SLLDPEEGIR FRGLSIPECQ KLLPGAKPGG
     EPLPEGLLWL LLTGKVPTKE QVDALSAELR SRAAVPEHVY KTIDALPVTA HPMTQFATGV
     MALQVQSEFQ KAYEKGIHKT KYWEPTYEDS ITLIAQLPVV AAYIYRRMYK NGQSISTDDS
     LDYGANFAHM LGYDSPSMQE LMRLYVTIHT DHEGGNVSAH TGHLVASALS DPYLSFAAAL
     NGLAGPLHGL ANQEVLLWIK SVVSECGENV TKEQLKDYIW KTLNSGKVVP GYGHGVLRNT
     DPRYICQREF ALKHLPDDPL FQLVSNLFEV VPPILTELGK VKNPWPNVDA HSGVLLNHYG
     LTEARYYTVL FGVSRAIGIC SQLVWDRALG LPLERPKSVT MEWLENHCKK SS
//
DBGET integrated database retrieval system