ID O83431_TREPA Unreviewed; 452 AA.
AC O83431;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 147.
DE RecName: Full=signal-recognition-particle GTPase {ECO:0000256|ARBA:ARBA00035672};
DE EC=3.6.5.4 {ECO:0000256|ARBA:ARBA00035672};
GN OrderedLocusNames=TP_0416 {ECO:0000313|EMBL:AAC65403.1};
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65403.1, ECO:0000313|Proteomes:UP000000811};
RN [1] {ECO:0000313|EMBL:AAC65403.1, ECO:0000313|Proteomes:UP000000811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols {ECO:0000313|EMBL:AAC65403.1,
RC ECO:0000313|Proteomes:UP000000811};
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.4;
CC Evidence={ECO:0000256|ARBA:ARBA00035577};
CC -!- SIMILARITY: Belongs to the GTP-binding SRP family. SRP54 subfamily.
CC {ECO:0000256|ARBA:ARBA00005450}.
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DR EMBL; AE000520; AAC65403.1; -; Genomic_DNA.
DR PIR; F71327; F71327.
DR RefSeq; WP_010881864.1; NC_021490.2.
DR AlphaFoldDB; O83431; -.
DR STRING; 243276.TP_0416; -.
DR EnsemblBacteria; AAC65403; AAC65403; TP_0416.
DR KEGG; tpa:TP_0416; -.
DR PATRIC; fig|243276.9.peg.415; -.
DR eggNOG; COG0541; Bacteria.
DR HOGENOM; CLU_009301_6_0_12; -.
DR OrthoDB; 9804720at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0048500; C:signal recognition particle; IEA:InterPro.
DR GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.120.140; Signal recognition particle SRP54, nucleotide-binding domain; 1.
DR Gene3D; 1.10.260.30; Signal recognition particle, SRP54 subunit, M-domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036891; Signal_recog_part_SRP54_M_sf.
DR InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR InterPro; IPR004125; Signal_recog_particle_SRP54_M.
DR InterPro; IPR004780; SRP.
DR InterPro; IPR022941; SRP54.
DR InterPro; IPR000897; SRP54_GTPase_dom.
DR InterPro; IPR042101; SRP54_N_sf.
DR NCBIfam; TIGR00959; ffh; 1.
DR PANTHER; PTHR11564:SF5; SIGNAL RECOGNITION PARTICLE 54 KDA PROTEIN; 1.
DR PANTHER; PTHR11564; SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54; 1.
DR Pfam; PF00448; SRP54; 1.
DR Pfam; PF02881; SRP54_N; 1.
DR Pfam; PF02978; SRP_SPB; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00962; SRP54; 1.
DR SMART; SM00963; SRP54_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47446; Signal peptide-binding domain; 1.
DR PROSITE; PS00300; SRP54; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000811};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Signal recognition particle {ECO:0000256|ARBA:ARBA00023135}.
FT DOMAIN 273..286
FT /note="SRP54-type proteins GTP-binding"
FT /evidence="ECO:0000259|PROSITE:PS00300"
FT REGION 433..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 452 AA; 49258 MW; CBCA66F80AD77583 CRC64;
MFEQLSASFK RIVGALGGRA TISERNIQEA VESIKRALLD ADVHVRVVRR FVNQTIQHAQ
GQTVLASVSP AQQFIKIVHE RLTAFLGEHT RSLHLKGPDT QSIILLLGLQ GSGKTTSAAK
LAAYLKDAGR SPLLAACDHV RAAASAQLAV LGTHIGVPVY QHALPHEQQP CALDTARGAL
QYARSHGNDV LIIDTAGRLH VDAALMQELI LLKETLVPVE TLLVADALTG QTVVRIAEEF
HAAVGISGVV LSKFDSDTRG GAALSLKSIT GQPLLFVGTG ERPQDFEPFH PERAAGRILG
MGDIVSLVEK AQKAFDAQEH ARAQKKTQSH ERFTLSDMLD HLQTIEKMGP LHSLVEMIPG
LAVAVSADAL DARAFKRQKA IIQSMTVQER DNFLIIGPSR RRRIAAGSGT SVADVNRLIK
NFERMRTLMR KTAWQSRRAH PKGDTPYGWP HR
//
