ID O83498_TREPA Unreviewed; 614 AA.
AC O83498;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE SubName: Full=Adenylate cyclase {ECO:0000313|EMBL:AAC65466.1};
GN OrderedLocusNames=TP_0485 {ECO:0000313|EMBL:AAC65466.1};
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65466.1, ECO:0000313|Proteomes:UP000000811};
RN [1] {ECO:0000313|EMBL:AAC65466.1, ECO:0000313|Proteomes:UP000000811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols {ECO:0000313|EMBL:AAC65466.1,
RC ECO:0000313|Proteomes:UP000000811};
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
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DR EMBL; AE000520; AAC65466.1; -; Genomic_DNA.
DR PIR; C71320; C71320.
DR RefSeq; WP_010881934.1; NC_021490.2.
DR AlphaFoldDB; O83498; -.
DR IntAct; O83498; 7.
DR STRING; 243276.TP_0485; -.
DR EnsemblBacteria; AAC65466; AAC65466; TP_0485.
DR GeneID; 57879005; -.
DR KEGG; tpa:TP_0485; -.
DR PATRIC; fig|243276.9.peg.482; -.
DR eggNOG; COG2114; Bacteria.
DR eggNOG; COG2972; Bacteria.
DR HOGENOM; CLU_016487_0_0_12; -.
DR OrthoDB; 9806704at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000811};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 309..361
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 393..528
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 614 AA; 67030 MW; DB30561FE1071BC5 CRC64;
MSRKNANQKI VWPLTTKLIG IISTVVVLAT IAVTAMASWF FASSLHSNAE LNNLAAAENF
AAQIKGEFEA IATSAKSFVS LGLRSGARMH SRSALSKDFF SFYPRIGYIG VGGVAELWNG
DFFKKNQLRV ADARRFLADN AQVISTLQTA PATLNAAPWF KAQIIAIVAP FEVDGATRNV
VVIFSADVVQ HLLESGASSG TMYAVTWAGN SLYHPEYSLN YSNINLQDSP VVRDLRESTQ
LTKQISFIGT DNKRYFGAFA KQTFGKFAIV LETPMSVVYQ AVYYAIILDG ILTGMVLLAS
ILLVWFIAQS ITRPILTLVG ATHAISSGQF LLDIKPSSKD EIGLLTETFV SMGRGLAERE
RMKEAFGKFV NRDIAEKAMK GELALGGERK TATIFFSDVR SFTEMSEKLP PEDVVEFLNE
YMSCMVDCIE QTGGVVDKFI GDAIMAIWGA PVSLGSARLD ALQSMKAVFL MRESLIQLNE
KRVACSKPRI GIGCGVNTGS CVAGQIGSSK RMEYTVIGDA VNTASRIEAL NKPFGTDFLI
SENTYELVKD MLIVEKMPPI TVKGKREPLN VYAAINLKGH DGPQTLDELR ALLSIEKPGL
SADPDFEEKK CEVI
//
