ID O83538_TREPA Unreviewed; 668 AA.
AC O83538;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 24-JAN-2024, entry version 147.
DE SubName: Full=ATP-dependent helicase (HrpA) {ECO:0000313|EMBL:AAC65513.1};
GN OrderedLocusNames=TP_0526 {ECO:0000313|EMBL:AAC65513.1};
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65513.1, ECO:0000313|Proteomes:UP000000811};
RN [1] {ECO:0000313|EMBL:AAC65513.1, ECO:0000313|Proteomes:UP000000811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols {ECO:0000313|EMBL:AAC65513.1,
RC ECO:0000313|Proteomes:UP000000811};
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
CC -!- INTERACTION:
CC O83538; O83862: nusA; NbExp=2; IntAct=EBI-1585740, EBI-1585751;
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DR EMBL; AE000520; AAC65513.1; -; Genomic_DNA.
DR PIR; H71312; H71312.
DR RefSeq; WP_010881974.1; NC_021490.2.
DR AlphaFoldDB; O83538; -.
DR IntAct; O83538; 10.
DR STRING; 243276.TP_0526; -.
DR EnsemblBacteria; AAC65513; AAC65513; TP_0526.
DR GeneID; 57879050; -.
DR KEGG; tpa:TP_0526; -.
DR PATRIC; fig|243276.9.peg.522; -.
DR eggNOG; COG1643; Bacteria.
DR HOGENOM; CLU_001832_5_11_12; -.
DR OMA; MKVYPLY; -.
DR OrthoDB; 9808833at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:AAC65513.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000811}.
FT DOMAIN 17..180
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 207..382
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 632..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..668
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 668 AA; 75453 MW; B0209A1C981BCD92 CRC64;
MFSYKQLPVY SQKDKILSAL AHHHVIVVES PTGSGKTTQL PLILHEAGYN EGGAIGVTQP
RRIAVLSVSE FIAKQVLHVQ PGIVGYKMRF EDHTDVETKI KVMTDGILLQ EMKLDPLLSK
YSIIMVDEAH ERSLNIDFIL GLLKRVLQQR HDFRIVISSA TINTAMFSRY FNECPVIKID
AVAYPVTVIF DPPDTPASTH TKEAEAALLE KIVCIVERVI ASRDKGAILI FLPGERSIKN
CITRLSHERW FRKLFLLPLY GRLSKEEQEQ VFNRAPFGKR KVVIATNIAE TSITIDDVTT
VIDSGLVKLN SYNPLSYTAS LDETPISQAS CNQRRGRAGR VRAGTCYRLY SRDDFEQREP
YTLEEIYRTD LSEVVMRMAE LGIHDFEHFD FISPPGTHGI IGAEDTLRLL GALEDDRSLS
EIGKMMCLFP LGPRQSRMIV EALRRYPHSI DDVLIAAAFL SARSPLIFSE DQEEKTKKAH
GTFSDPMGDF VSFLRIYRAY AQENNKHSFC QHFYLDERIM AEISNIKEQL ELIVSGMGFP
LLTGGTVEEY LICVGTGMIQ FVCVQEHRDS YRSLTAECIH IHPGSCVYKD RPKFIVAGEI
VRTSRMYAMS VSPLSKKIAE LIAPALLERR GRAEKHGTSP TRAAFLKKST LRKGPRKRRV
RVGRASLR
//