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Database: UniProt
Entry: O83538_TREPA
LinkDB: O83538_TREPA
Original site: O83538_TREPA 
ID   O83538_TREPA            Unreviewed;       668 AA.
AC   O83538;
DT   01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1998, sequence version 1.
DT   24-JAN-2024, entry version 147.
DE   SubName: Full=ATP-dependent helicase (HrpA) {ECO:0000313|EMBL:AAC65513.1};
GN   OrderedLocusNames=TP_0526 {ECO:0000313|EMBL:AAC65513.1};
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65513.1, ECO:0000313|Proteomes:UP000000811};
RN   [1] {ECO:0000313|EMBL:AAC65513.1, ECO:0000313|Proteomes:UP000000811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols {ECO:0000313|EMBL:AAC65513.1,
RC   ECO:0000313|Proteomes:UP000000811};
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA   Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA   Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA   Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA   Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA   Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- INTERACTION:
CC       O83538; O83862: nusA; NbExp=2; IntAct=EBI-1585740, EBI-1585751;
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DR   EMBL; AE000520; AAC65513.1; -; Genomic_DNA.
DR   PIR; H71312; H71312.
DR   RefSeq; WP_010881974.1; NC_021490.2.
DR   AlphaFoldDB; O83538; -.
DR   IntAct; O83538; 10.
DR   STRING; 243276.TP_0526; -.
DR   EnsemblBacteria; AAC65513; AAC65513; TP_0526.
DR   GeneID; 57879050; -.
DR   KEGG; tpa:TP_0526; -.
DR   PATRIC; fig|243276.9.peg.522; -.
DR   eggNOG; COG1643; Bacteria.
DR   HOGENOM; CLU_001832_5_11_12; -.
DR   OMA; MKVYPLY; -.
DR   OrthoDB; 9808833at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd17917; DEXHc_RHA-like; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   1: Evidence at protein level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000313|EMBL:AAC65513.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000811}.
FT   DOMAIN          17..180
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          207..382
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          632..668
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        649..668
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   668 AA;  75453 MW;  B0209A1C981BCD92 CRC64;
     MFSYKQLPVY SQKDKILSAL AHHHVIVVES PTGSGKTTQL PLILHEAGYN EGGAIGVTQP
     RRIAVLSVSE FIAKQVLHVQ PGIVGYKMRF EDHTDVETKI KVMTDGILLQ EMKLDPLLSK
     YSIIMVDEAH ERSLNIDFIL GLLKRVLQQR HDFRIVISSA TINTAMFSRY FNECPVIKID
     AVAYPVTVIF DPPDTPASTH TKEAEAALLE KIVCIVERVI ASRDKGAILI FLPGERSIKN
     CITRLSHERW FRKLFLLPLY GRLSKEEQEQ VFNRAPFGKR KVVIATNIAE TSITIDDVTT
     VIDSGLVKLN SYNPLSYTAS LDETPISQAS CNQRRGRAGR VRAGTCYRLY SRDDFEQREP
     YTLEEIYRTD LSEVVMRMAE LGIHDFEHFD FISPPGTHGI IGAEDTLRLL GALEDDRSLS
     EIGKMMCLFP LGPRQSRMIV EALRRYPHSI DDVLIAAAFL SARSPLIFSE DQEEKTKKAH
     GTFSDPMGDF VSFLRIYRAY AQENNKHSFC QHFYLDERIM AEISNIKEQL ELIVSGMGFP
     LLTGGTVEEY LICVGTGMIQ FVCVQEHRDS YRSLTAECIH IHPGSCVYKD RPKFIVAGEI
     VRTSRMYAMS VSPLSKKIAE LIAPALLERR GRAEKHGTSP TRAAFLKKST LRKGPRKRRV
     RVGRASLR
//
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