ID O83579_TREPA Unreviewed; 774 AA.
AC O83579;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE SubName: Full=Aminopeptidase P {ECO:0000313|EMBL:AAC65543.1};
GN OrderedLocusNames=TP_0569 {ECO:0000313|EMBL:AAC65543.1};
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65543.1, ECO:0000313|Proteomes:UP000000811};
RN [1] {ECO:0000313|EMBL:AAC65543.1, ECO:0000313|Proteomes:UP000000811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols {ECO:0000313|EMBL:AAC65543.1,
RC ECO:0000313|Proteomes:UP000000811};
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
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DR EMBL; AE000520; AAC65543.1; -; Genomic_DNA.
DR PIR; G71308; G71308.
DR AlphaFoldDB; O83579; -.
DR IntAct; O83579; 1.
DR STRING; 243276.TP_0569; -.
DR EnsemblBacteria; AAC65543; AAC65543; TP_0569.
DR KEGG; tpa:TP_0569; -.
DR PATRIC; fig|243276.9.peg.565; -.
DR eggNOG; COG0006; Bacteria.
DR HOGENOM; CLU_011781_2_1_12; -.
DR OrthoDB; 9806388at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 2.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:AAC65543.1};
KW Hydrolase {ECO:0000313|EMBL:AAC65543.1};
KW Protease {ECO:0000313|EMBL:AAC65543.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000811}.
FT DOMAIN 35..164
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 430..673
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 715..773
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
FT REGION 347..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 774 AA; 83723 MW; 1ABAC7A88CAB7448 CRC64;
MIPLGKRHGH SAVAVCSRGV SVFRGEKAMD GVRGRLSALR SLMRAQGVDI CYISGENAHG
QIDGAREYFS GFTGSAGIVV VTAQRAFLWT DGRYFIQAER ELSACEVCLF RTGQAGVPRV
TELLRTELRA FSSGPGHGGG TLAVDGRTIS AAVWEQFQQE LVDVSLRLDF DGALLLPQEH
RVSVVPSPAF LLDERYTGLS AAQKLTQLRA ALSARSCDAT VLSTLDDVCW LTNVRAHDVP
CTPLLVAYMV VTHTRAFLYV DMRKISSALH QALYAQGVEC MPYDTFFDQV CARCADQEPT
VHAVGKGRAG VQEVAGRTPV VLLDFERSCA ALVDLFRASP QVCRPQVERS APSGSLSSVL
GIEEDGTETS RGGKSACALQ SARDALAAGK EKENKEERGQ TMCFSVCRGL LPTVALKALK
NDTERANVHQ AMIQDGIALV KTLQWVYQQL DVGADVDECA VAEFVRAARA VSPSFIEESF
HTIAGYGANA AMVHYRPVRF SALHPAAGQT AALLRARGFL LLDSGAHYRE GTTDVTRTLA
LGPLTDVQRA DYTLVLQAHS ALARARFPAG TSGAVLDGIA RAPLWAQGRD YPHGTGHGVG
FCLSVHEGPY SISPSAPGRG GTARGIGAEH TGDPPFFSEE AAWQLRPGML LSNEPGVYVA
GSHGVRIENL MWVVQAHESD AQCVWKEGGE GKEENAAARE CTGADRMQPS RCRSFYGFQT
ATLCPIDTRP LVRERLHDED IAWLNAYHLR VYVTLAPFLD ARTRAFLRTC CRAL
//
