ID O83693_TREPA Unreviewed; 597 AA.
AC O83693;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 135.
DE SubName: Full=Phosphoribosylglycinamide formyltransferase, putative {ECO:0000313|EMBL:AAC65662.1};
GN OrderedLocusNames=TP_0695 {ECO:0000313|EMBL:AAC65662.1};
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65662.1, ECO:0000313|Proteomes:UP000000811};
RN [1] {ECO:0000313|EMBL:AAC65662.1, ECO:0000313|Proteomes:UP000000811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols {ECO:0000313|EMBL:AAC65662.1,
RC ECO:0000313|Proteomes:UP000000811};
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE000520; AAC65662.1; -; Genomic_DNA.
DR PIR; D71293; D71293.
DR RefSeq; WP_010882140.1; NC_021490.2.
DR AlphaFoldDB; O83693; -.
DR IntAct; O83693; 2.
DR STRING; 243276.TP_0695; -.
DR EnsemblBacteria; AAC65662; AAC65662; TP_0695.
DR KEGG; tpa:TP_0695; -.
DR PATRIC; fig|243276.9.peg.687; -.
DR eggNOG; COG1181; Bacteria.
DR HOGENOM; CLU_029016_5_0_12; -.
DR OrthoDB; 9803907at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR041472; BL00235/CARNS1_N.
DR InterPro; IPR040570; LAL_C2.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR PANTHER; PTHR43585:SF2; ATP-GRASP ENZYME FSQD; 1.
DR PANTHER; PTHR43585; FUMIPYRROLE BIOSYNTHESIS PROTEIN C; 1.
DR Pfam; PF13535; ATP-grasp_4; 1.
DR Pfam; PF18130; ATPgrasp_N; 1.
DR Pfam; PF18603; LAL_C2; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000000811}.
FT DOMAIN 110..335
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 597 AA; 63326 MW; 7B775117C9BFD6A6 CRC64;
MKTILILGAG TMQAPALRAA RELGLWVCAV DGNPHAPCAA LADEFTPIDL ADSAALVAHA
RAIRARRGLD AVFTAATDFS VSVAAVAEAC ALPGHRLEAT KNATDKTRMR ACFTRARLRC
PRFTFLEPDS FAWDTPPGHA RLCSHLHSAG LSFPLVVKPT DNMGARGCTL AQCKDTLINA
CAVARQFSRS GRVIIEEFIV GREFSLEGLI FDGTLYVTAL ADRHICFPPS FVEMGHTLPA
ALCTQDAQAL IDTFHNGVRA LGLTHGAVKG DLFLSTPSPT KTPSTAATPN PSAPYTPEAV
LGEIAARLSG GFMSGWTVPY ALGFDVTRAA LHVALHGPSA AASAATASVA PPPTALTVLR
TQLTTLSPLP EKSPYASAER AWISIPGVIH RIWGLADAQQ IAYVKNVFVR MQEGAAVRFP
RNNVEKCGNV LSQAPTRAQA IAAAETACRC IVLRLVPAHP ATDAFLARKR SAESAASPAL
QDADSEYAAS ASHPFGQESI PDIVCDASGR FFTSEVACAP LVRTGLFLIP EPLVRADARD
VQGRSIHALC TLALKVEPAL EPALCFARSQ NLAELWRALI RGGIQGLLYA FDSFQLS
//
