ID O83750_TREPA Unreviewed; 593 AA.
AC O83750;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Conserved hypothetical integral membrane protein {ECO:0000313|EMBL:AAC65739.1};
GN OrderedLocusNames=TP_0771 {ECO:0000313|EMBL:AAC65739.1};
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65739.1, ECO:0000313|Proteomes:UP000000811};
RN [1] {ECO:0000313|EMBL:AAC65739.1, ECO:0000313|Proteomes:UP000000811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols {ECO:0000313|EMBL:AAC65739.1,
RC ECO:0000313|Proteomes:UP000000811};
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AE000520; AAC65739.1; -; Genomic_DNA.
DR PIR; H71283; H71283.
DR AlphaFoldDB; O83750; -.
DR IntAct; O83750; 3.
DR STRING; 243276.TP_0771; -.
DR EnsemblBacteria; AAC65739; AAC65739; TP_0771.
DR KEGG; tpa:TP_0771; -.
DR PATRIC; fig|243276.9.peg.758; -.
DR eggNOG; COG1283; Bacteria.
DR HOGENOM; CLU_025623_0_1_12; -.
DR OrthoDB; 9763003at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005436; F:sodium:phosphate symporter activity; IEA:InterPro.
DR GO; GO:0044341; P:sodium-dependent phosphate transport; IEA:InterPro.
DR InterPro; IPR003841; Na/Pi_transpt.
DR InterPro; IPR004633; NaPi_cotrn-rel/YqeW-like.
DR InterPro; IPR038078; PhoU-like_sf.
DR NCBIfam; NF037997; Na_Pi_symport; 1.
DR NCBIfam; TIGR00704; NaPi_cotrn_rel; 1.
DR PANTHER; PTHR10010:SF46; SODIUM_PHOSPHATE COTRANSPORTER-RELATED; 1.
DR PANTHER; PTHR10010; SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED; 1.
DR Pfam; PF02690; Na_Pi_cotrans; 2.
DR SUPFAM; SSF109755; PhoU-like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 593 AA; 65374 MW; A7D57A08B090A0FE CRC64;
MSRRDYLRKE RLTNKHTSVR RSVPLRTIDT YPLFLLWWAP MHLVAVLLQG IGSLGFMLFG
MKLMSDGIQK GTGESLHKIL QVMTSNCFFA VLTGMAVTAI VQSSGATTVM TISFINAGVL
SLTQSIGVIL GANIGTTVTA WIVALVGFQF KLASIAVPAF GIGYFLTFFK HLHKGHLGES
IMGFGLLFTG LGLLSSLIPP LSVEELSFLK IAVEDRALSV FVGLLSGFVL TVILHSSSAT
TAIVLTMAFG GVIGVEFAAA SVLGSNVGST IDAAIAAIGS KLNARRAAAV HVLFNVFGAL
VFLMFFHPVL ALLCVLTPKN SGFDNITVRL ALFHSMFNIV NTIIVFPFTK HLAAFVEWLI
RPRYDDAPER YQLVFQETAV KESAEAHIFR AEIELKKMFS IAQGMLVTIR KSIQGTCMLS
TDEIVTRLTK EEDYADQMQE QLSRFLIKTS HLSLSEKAKH NVQLMFSIAD DIENITDHLC
GIGLYFHKSI KGNVPLKRDD IEELVPYVGM VDECVDFVYS HLNRPLEDKQ VLHVNQMTHS
IESKGAHLKG LVRRRLEQGA DVKAELLYMD IVRGIEAVGN YALSISRWLA RML
//
