ID   BLO20_PSEAI             Reviewed;         266 AA.
AC   O84955;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   29-MAY-2013, entry version 63.
DE   RecName: Full=Beta-lactamase OXA-20;
DE            EC=3.5.2.6;
DE   AltName: Full=Penicillinase;
DE   Flags: Precursor;
GN   Name=bla; Synonyms=oxa20;
OS   Pseudomonas aeruginosa.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Mus;
RX   PubMed=9687410;
RA   Naas T., Sougakoff W., Casetta A., Nordmann P.;
RT   "Molecular characterization of OXA-20, a novel class D beta-lactamase,
RT   and its integron from Pseudomonas aeruginosa.";
RL   Antimicrob. Agents Chemother. 42:2074-2083(1998).
CC   -!- FUNCTION: This is an oxacillin-hydrolyzing beta-lactamase.
CC   -!- CATALYTIC ACTIVITY: A beta-lactam + H(2)O = a substituted beta-
CC       amino acid.
CC   -!- ENZYME REGULATION: Inhibited by clavulanic acid.
CC   -!- SIMILARITY: Belongs to the class-D beta-lactamase family.
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DR   EMBL; AF024602; AAC23554.1; -; Genomic_DNA.
DR   ProteinModelPortal; O84955; -.
DR   SMR; O84955; 25-265.
DR   GO; GO:0008800; F:beta-lactamase activity; IEA:EC.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0017001; P:antibiotic catabolic process; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; -; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR002137; Beta-lactam_class-D_AS.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; PBP_transp_fold; 1.
DR   PROSITE; PS00337; BETA_LACTAMASE_D; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Hydrolase; Signal.
FT   SIGNAL        1     21       Potential.
FT   CHAIN        22    266       Beta-lactamase OXA-20.
FT                                /FTId=PRO_0000017034.
FT   REGION      210    212       Substrate binding (By similarity).
FT   ACT_SITE     72     72       Acyl-ester intermediate (By similarity).
FT   MOD_RES      75     75       N6-carboxylysine (By similarity).
SQ   SEQUENCE   266 AA;  30449 MW;  8E7270EA924F2FB9 CRC64;
     MIIRFLALLF SAVVLVSLGH AQEKTHESSN WGKYFSDFNA KGTIVVVDER TNGNSTSVYN
     ESRAQQRYSP ASTFKIPHTL FALDAGAVRD EFHVFRWDGA KRSFAGHNQD QNLRSAMRNS
     TVWVYQLFAK EIGENKARSY LEKLNYGNAD PSTKSGDYWI DGNLAISANE QISILKKLYR
     NELPFRVEHQ RLVKDLMIVE AKRDWILRAK TGWDGQMGWW VGWVEWPTGP VFFALNIDTP
     NRMEDLHKRE AIARAILQSV NALPPN
//