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Database: UniProt
Entry: O86408
LinkDB: O86408
Original site: O86408 
ID   OTC_NEIPH               Reviewed;         232 AA.
AC   O86408;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   09-JUL-2014, entry version 68.
DE   RecName: Full=Ornithine carbamoyltransferase;
DE            Short=OTCase;
DE            EC=2.1.3.3;
DE   Flags: Fragment;
GN   Name=argF;
OS   Neisseria pharyngis.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC   Neisseriaceae; Neisseria.
OX   NCBI_TaxID=29434;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NCTC 4590 / Flava;
RX   PubMed=10368955; DOI=10.1093/oxfordjournals.molbev.a026162;
RA   Smith N.H., Holmes E.C., Donovan G.M., Carpenter G.A., Spratt B.G.;
RT   "Networks and groups within the genus Neisseria: analysis of argF,
RT   recA, rho, and 16S rRNA sequences from human Neisseria species.";
RL   Mol. Biol. Evol. 16:773-783(1999).
CC   -!- FUNCTION: Reversibly catalyzes the transfer of the carbamoyl group
CC       from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine
CC       (ORN) to produce L-citrulline (By similarity).
CC   -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-ornithine = phosphate
CC       + L-citrulline.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-
CC       arginine from L-ornithine and carbamoyl phosphate: step 1/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR   EMBL; AJ223905; CAA11636.1; -; Genomic_DNA.
DR   ProteinModelPortal; O86408; -.
DR   SMR; O86408; 1-232.
DR   UniPathway; UPA00068; UER00112.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004585; F:ornithine carbamoyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.1370; -; 2.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR   InterPro; IPR002292; Orn/put_carbamltrans.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00102; OTCASE.
DR   SUPFAM; SSF53671; SSF53671; 1.
DR   TIGRFAMs; TIGR00658; orni_carb_tr; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm;
KW   Transferase.
FT   CHAIN        <1   >232       Ornithine carbamoyltransferase.
FT                                /FTId=PRO_0000112969.
FT   REGION       66     69       Carbamoyl phosphate binding (By
FT                                similarity).
FT   REGION      167    168       Ornithine binding (By similarity).
FT   REGION      204    207       Carbamoyl phosphate binding (By
FT                                similarity).
FT   BINDING       4      4       Carbamoyl phosphate (By similarity).
FT   BINDING      15     15       Carbamoyl phosphate (By similarity).
FT   BINDING      39     39       Carbamoyl phosphate (By similarity).
FT   BINDING      99     99       Ornithine (By similarity).
FT   BINDING     163    163       Ornithine (By similarity).
FT   BINDING     232    232       Carbamoyl phosphate (By similarity).
FT   SITE         79     79       Important for structural integrity (By
FT                                similarity).
FT   NON_TER       1      1
FT   NON_TER     232    232
SQ   SEQUENCE   232 AA;  25640 MW;  3223C9ADDC2EF01E CRC64;
     DQGAGVTYLE PSASQIGHKE SIKDTARVLG RMYDGIEYRG FGQDVVEELA KYAGVPVFNG
     LTNEFHPTQM LADALTMREH SGKPLSQTAF AYVGDARYNM ANSLLVLGAK LGMDVRIGAP
     KTLWPSEHIV ARARAVAKET GGRILLTENA EEAVKGVDFI HTDVWVSMGE PKEAWQERID
     LLKDYRVTPE LMAASGNPQV KFMHCLPAFH NRETKVGEWI YETFGLNGVE VT
//
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