ID OTC_NEIPH Reviewed; 232 AA.
AC O86408;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 29-MAY-2013, entry version 64.
DE RecName: Full=Ornithine carbamoyltransferase;
DE Short=OTCase;
DE EC=2.1.3.3;
DE Flags: Fragment;
GN Name=argF;
OS Neisseria pharyngis.
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC Neisseriaceae; Neisseria.
OX NCBI_TaxID=29434;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NCTC 4590 / Flava;
RX PubMed=10368955;
RA Smith N.H., Holmes E.C., Donovan G.M., Carpenter G.A., Spratt B.G.;
RT "Networks and groups within the genus Neisseria: analysis of argF,
RT recA, rho, and 16S rRNA sequences from human Neisseria species.";
RL Mol. Biol. Evol. 16:773-783(1999).
CC -!- FUNCTION: Reversibly catalyzes the transfer of the carbamoyl group
CC from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine
CC (ORN) to produce L-citrulline (By similarity).
CC -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-ornithine = phosphate
CC + L-citrulline.
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-
CC arginine from L-ornithine and carbamoyl phosphate: step 1/3.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR EMBL; AJ223905; CAA11636.1; -; Genomic_DNA.
DR ProteinModelPortal; O86408; -.
DR SMR; O86408; 1-232.
DR UniPathway; UPA00068; UER00112.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004585; F:ornithine carbamoyltransferase activity; IEA:EC.
DR GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006591; P:ornithine metabolic process; IEA:GOC.
DR Gene3D; 3.40.50.1370; -; 2.
DR HAMAP; MF_01109; OTCase; 1; -.
DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR InterPro; IPR002292; Orn/put_carbamltrans.
DR Pfam; PF00185; OTCace; 1.
DR Pfam; PF02729; OTCace_N; 1.
DR PRINTS; PR00100; AOTCASE.
DR PRINTS; PR00102; OTCASE.
DR SUPFAM; SSF53671; Asp/Orn_carbamoyltranf; 1.
DR TIGRFAMs; TIGR00658; orni_carb_tr; 1.
DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; PARTIAL.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm;
KW Transferase.
FT CHAIN <1 >232 Ornithine carbamoyltransferase.
FT /FTId=PRO_0000112969.
FT REGION 66 69 Carbamoyl phosphate binding (By
FT similarity).
FT REGION 167 168 Ornithine binding (By similarity).
FT REGION 204 207 Carbamoyl phosphate binding (By
FT similarity).
FT BINDING 4 4 Carbamoyl phosphate (By similarity).
FT BINDING 15 15 Carbamoyl phosphate (By similarity).
FT BINDING 39 39 Carbamoyl phosphate (By similarity).
FT BINDING 99 99 Ornithine (By similarity).
FT BINDING 163 163 Ornithine (By similarity).
FT BINDING 232 232 Carbamoyl phosphate (By similarity).
FT SITE 79 79 Important for structural integrity (By
FT similarity).
FT NON_TER 1 1
FT NON_TER 232 232
SQ SEQUENCE 232 AA; 25640 MW; 3223C9ADDC2EF01E CRC64;
DQGAGVTYLE PSASQIGHKE SIKDTARVLG RMYDGIEYRG FGQDVVEELA KYAGVPVFNG
LTNEFHPTQM LADALTMREH SGKPLSQTAF AYVGDARYNM ANSLLVLGAK LGMDVRIGAP
KTLWPSEHIV ARARAVAKET GGRILLTENA EEAVKGVDFI HTDVWVSMGE PKEAWQERID
LLKDYRVTPE LMAASGNPQV KFMHCLPAFH NRETKVGEWI YETFGLNGVE VT
//
