ID O86799_STRCO Unreviewed; 426 AA.
AC O86799;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=Methyltransferase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=SCO4758 {ECO:0000313|EMBL:CAA20414.1};
GN ORFNames=SC6G4.36c {ECO:0000313|EMBL:CAA20414.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAA20414.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAA20414.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
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DR EMBL; AL939121; CAA20414.1; -; Genomic_DNA.
DR PIR; T35587; T35587.
DR RefSeq; NP_628916.1; NC_003888.3.
DR AlphaFoldDB; O86799; -.
DR STRING; 100226.gene:17762407; -.
DR PaxDb; 100226-SCO4758; -.
DR PATRIC; fig|100226.15.peg.4830; -.
DR eggNOG; COG2265; Bacteria.
DR HOGENOM; CLU_038123_1_1_11; -.
DR InParanoid; O86799; -.
DR OrthoDB; 9810570at2; -.
DR PhylomeDB; O86799; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0009058; P:biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR041497; Thump-like.
DR PANTHER; PTHR14741; S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED; 1.
DR PANTHER; PTHR14741:SF32; TRIMETHYLGUANOSINE SYNTHASE; 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR Pfam; PF18096; Thump_like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001973}.
FT DOMAIN 135..202
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13649"
FT DOMAIN 353..423
FT /note="THUMP-like"
FT /evidence="ECO:0000259|Pfam:PF18096"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 426 AA; 44942 MW; 12717D33308917D5 CRC64;
MYDCSHGAGS SQSPAAEPGP TPRRRHTIHR LAHNDPVNDL DFLLTPEGRA LLDEVRDTDP
VRELAVATRL RRTHPAELVS AALGQARLRQ RAVAKFGAED AGRMFFTPNG VEQSTRASVA
AYRAGRFAAL GVASVADLCC GIGGDAIALA RAGIRVLAVD RDPVTAAAAR ANADALGLAG
LIEVREADVT EVDTEAYDAV FVDPARRGGR GRIFDPEAYS PPLSWAVRAA RTASRAAALK
VAPGIPHEAV PEDAEAEWIS DGGDVKEAVL WFGAGAAPGA VRATLLPGPR TLPGTGLPDP
EVRTPGRYLY EPDGAVIRAH LVAEVAAQVG GGLLDATIAY VTADELLPTP YATAYEITDR
MPFNVKKLKA LLRERGVGTL TVKKRGSAVE PEELRRKVKP QGPNSATVFL TRVAGAPTML
VGHPAR
//
