ID NRDR_STRC2 Reviewed; 172 AA.
AC O86848;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-APR-2013, entry version 57.
DE RecName: Full=Transcriptional repressor NrdR;
GN Name=nrdR;
OS Streptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 /
OS NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Streptomycineae; Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=443255;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 /
RC NRRL 3585 / VKM Ac-602;
RA Kreisberg-Zakarin R., Borovok I., Schreiber R., Holmgren A.,
RA Aslund F., Reichard P., Cohen G., Aharonowitz Y.;
RT "Streptomyces clavuligerus vitamin B12-dependent ribonucleotide
RT reductase enzyme: from protein to gene.";
RL Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION.
RX PubMed=15949864; DOI=10.1016/j.tig.2005.05.011;
RA Rodionov D.A., Gelfand M.S.;
RT "Identification of a bacterial regulatory system for ribonucleotide
RT reductases by phylogenetic profiling.";
RL Trends Genet. 21:385-389(2005).
CC -!- FUNCTION: Negatively regulates transcription of bacterial
CC ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC boxes (By similarity).
CC -!- COFACTOR: Binds 1 zinc ion (By similarity).
CC -!- SIMILARITY: Belongs to the NrdR family.
CC -!- SIMILARITY: Contains 1 ATP-cone domain.
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DR EMBL; AJ224870; CAA12170.1; -; Genomic_DNA.
DR PATRIC; 29747573; VBIStrCla15562_3093.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:HAMAP.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:HAMAP.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR HAMAP; MF_00440; NrdR; 1; -.
DR InterPro; IPR005144; ATP-cone.
DR InterPro; IPR003796; RNR_NrdR-like.
DR Pfam; PF03477; ATP-cone; 1.
DR TIGRFAMs; TIGR00244; TIGR00244; 1.
DR PROSITE; PS51161; ATP_CONE; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding;
KW Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 172 Transcriptional repressor NrdR.
FT /FTId=PRO_0000182364.
FT DOMAIN 46 136 ATP-cone.
FT ZN_FING 3 34 By similarity.
SQ SEQUENCE 172 AA; 18689 MW; F3846A5190251ED2 CRC64;
MHCPFCRHPD SRVVDSRTTD DGTSIRRRRQ CPDCSRRFTT VETASLMVIK RSGVTEPFSR
TKVISGVRKA CQGRPVTEDA LAQLGQRVEE AVRATGSAEL TTHDVGLAIL GPLQELDLVA
YLRFASVYRA FDSLEDFEAA IAELREHRLP AERSGGGTCG TGTVPVPAGT AD
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