ID O93414_9TELE Unreviewed; 559 AA.
AC O93414;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Orphan G protein-coupled receptor {ECO:0000313|EMBL:AAC33474.1};
OS Sphoeroides nephelus (southern puffer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Sphoeroides.
OX NCBI_TaxID=39110 {ECO:0000313|EMBL:AAC33474.1};
RN [1] {ECO:0000313|EMBL:AAC33474.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10628755; DOI=10.1210/me.14.1.160;
RA Palyha O.C., Feighner S.D., Tan C.P., McKee K.K., Hreniuk D.L., Gao Y.D.,
RA Schleim K.D., Yang L., Morriello G.J., Nargund R., Patchett A.A.,
RA Howard A.D., Smith R.G.;
RT "Ligand activation domain of human orphan growth hormone (GH) secretagogue
RT receptor (GHS-R) conserved from Pufferfish to humans.";
RL Mol. Endocrinol. 14:160-169(2000).
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AF082211; AAC33474.1; -; Genomic_DNA.
DR AlphaFoldDB; O93414; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24243; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24243:SF3; MOTILIN RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 2.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 3.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 55..519
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 237..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 61957 MW; AFB9F35FAF0CD5F6 CRC64;
MAEIGSGCED ENCSLASGFL HKCSNQECHW EEPVFGMIVC VTIIYIPLML FGLLGNILTI
LVVWLRPYMR SSTYLYLSSL AVSDILILLL LPVDLYKLWR PRPWPFGEIF CKSTMFFSEC
CTFCSILHIT FISLERYLAV CWPFTAKTVV TRRRTRTIIG CIWLGAAISA APVWVMVGVE
EVQSEDQGLS GWRESGAWTG KEGEKGFIIG ERERENRDKG LKDEQLEEMN WKDKEMNECG
DKNGVTKGFK GGDKSLEVGE GTKEQEHGER AAEGEEAQNK MKEDEGGGGG EGDTDGGGRM
QVDTRECRCT DYAVSSGLLS AMLVLSNMYF LVPLCILGLV YGLIGRTLWL RSQISRRDVN
NRNTVKMLGV IVLVFVLCWL PFHVGRTIFF FSLGSDRPGV NASHALLDSR VPLELPPPGA
LGESDEAAGD AFSEAQTGRG DGGRAVLDTR GTEARSDGEA AGPSTPEATT ADPYDAENST
PLDDTHSHSQ YFLYYLSQYF NLVSSVLFYL SAAINPLLYN LMSERYRHAV HSLLPRRAGT
RARRLQTLTA VHSITTTTM
//
