ID O96456_PLAVI Unreviewed; 556 AA.
AC O96456;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 22-FEB-2023, entry version 60.
DE SubName: Full=Sporozoite surface protein 2 {ECO:0000313|EMBL:AAC97484.1};
GN Name=SSP2 {ECO:0000313|EMBL:AAC97484.1};
OS Plasmodium vivax (malaria parasite P. vivax).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5855 {ECO:0000313|EMBL:AAC97484.1};
RN [1] {ECO:0000313|EMBL:AAC97484.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sal I {ECO:0000313|EMBL:AAC97484.1};
RX PubMed=10462250; DOI=10.1016/S0264-410X(99)00146-2;
RA Rogers W.O., Gowda K., Hoffman S.L.;
RT "Construction and immunogenicity of DNA vaccine plasmids encoding four
RT Plasmodium vivax candidate vaccine antigens.";
RL Vaccine 17:3136-3144(1999).
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DR EMBL; AF063136; AAC97484.1; -; Genomic_DNA.
DR AlphaFoldDB; O96456; -.
DR SMR; O96456; -.
DR VEuPathDB; PlasmoDB:PVX_082735; -.
DR HOGENOM; CLU_471357_0_0_1; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd01471; vWA_micronemal_protein; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR16059; ANTHRAX TOXIN RECEPTOR; 1.
DR PANTHER; PTHR16059:SF25; THROMBOSPONDIN-RELATED ANONYMOUS PROTEIN; 1.
DR Pfam; PF00090; TSP_1; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..556
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004160610"
FT DOMAIN 44..230
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 280..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..299
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 556 AA; 61208 MW; 530B5A0C86E8F3A7 CRC64;
MKLLQNKSYL LVVFLLYVSI FARGDEKVVD EVKYSEEVCN ESVDLYLLVD GSGSIGYPNW
ITKVIPMLNG LINSLSLSRD TINLYMNLFG NYTTELIRLG SGQSIDKRQA LSKVTELRKT
YTPYGTTNMT AALDEVQKHL NDRVNREKAI QLVILMTDGV PNSKYRALEV ANKLKQRNVS
LAVIGIGQGI NHQFNRLIAG CRPREPNCKF YSYADWNEAV ALIKPFIAKV CTEVERVANC
GPWDPWTACS VTCGRGTHSR SRPSLHEKCT THMVSECEEG ECPVEPEPLP VPAPLPTVPE
DVNPRDTDDE NENPNFNKGL DVPDEDDDEV PPANERADGN PVEENVFPPA DDSVPDESNV
LPLPPTVPGG SSEEFPADVQ NNPDSPEELP IEQEVPQDNN VNEPERSDSK GYGVNEKVIP
NPLDNERDMA NKNKTVHPGR KDSARDRYAR PHGSTHVNNN RANENSDIPN NPVPSDYEQP
EDKAKKSSNN GYKTAGGVIA GLALVGCVGF AYNFVAGGGA AGMAGEPAPF DEAMAEDEKD
VAEADQFKLP EDNEWN
//
