ID O96620_DROME Unreviewed; 320 AA.
AC O96620;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 27-MAR-2024, entry version 149.
DE SubName: Full=Intermediate neuroblasts defective protein {ECO:0000313|EMBL:AAC97116.1};
GN Name=ind {ECO:0000313|EMBL:AAC97116.1,
GN ECO:0000313|FlyBase:FBgn0025776};
GN ORFNames=CG11551 {ECO:0000313|FlyBase:FBgn0025776};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAC97116.1};
RN [1] {ECO:0000313|EMBL:AAC97116.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9832510;
RA Weiss J.B., Von Ohlen T., Mellerick D.M., Dressler G., Doe C.Q.,
RA Scott M.P.;
RT "Dorsoventral patterning in the Drosophila central nervous system: the
RT intermediate neuroblasts defective homeobox gene specifies intermediate
RT column identity.";
RL Genes Dev. 12:3591-3602(1998).
RN [2] {ECO:0000313|EMBL:AAC97116.1}
RP NUCLEOTIDE SEQUENCE.
RA Weiss J., Von Ohlen T., Mellerick D., Dressler G., Doe C., Scott M.;
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR EMBL; AF095926; AAC97116.1; -; mRNA.
DR AlphaFoldDB; O96620; -.
DR IntAct; O96620; 10.
DR AGR; FB:FBgn0025776; -.
DR FlyBase; FBgn0025776; ind.
DR VEuPathDB; VectorBase:FBgn0025776; -.
DR HOGENOM; CLU_077496_0_0_1; -.
DR ExpressionAtlas; O96620; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IPI:FlyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0007420; P:brain development; TAS:FlyBase.
DR GO; GO:0007417; P:central nervous system development; IMP:FlyBase.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; TAS:FlyBase.
DR GO; GO:0007398; P:ectoderm development; TAS:FlyBase.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:FlyBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0007400; P:neuroblast fate determination; TAS:FlyBase.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0007389; P:pattern specification process; NAS:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR GO; GO:0007419; P:ventral cord development; HMP:FlyBase.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR PANTHER; PTHR45664:SF20; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 225..285
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 227..286
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 177..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 320 AA; 34524 MW; 9503653C4F5296B5 CRC64;
MSRSFLMDSL LSDRPNLSQK KEKLGSPVGS PTAAAAVAAA AMLPSIPMLP YPASYVGSYL
FSLGIQQQQQ QQQQQQQQAA AAAAAAAAAA ALQQHPHVSS SPGSLYHPYA QLFASKRKSS
GFSNYEGCYP SPPLSANPNS QQLPPIHNLY GSPVVGGLPL PEPGSFCTSP SASSSASLDY
TNNFDEPQGK RFKHESSCSP NSSPLKNHSS GGPVEITPLI NDYADSSKRI RTAFTSTQLL
ELEREFSHNA YLSRLRRIEI ANRLRLSEKQ VKIWFQNRRV KQKKGGSESP TFNLSTNSNG
SPQASPVSPQ VKVHELKVEA
//
