ID OR1E3_HUMAN Reviewed; 343 AA.
AC Q8WZA6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=Olfactory receptor 1E3;
DE AltName: Full=Olfactory receptor 17-210;
DE Short=OR17-210;
DE AltName: Full=Olfactory receptor OR17-7;
GN Name=OR1E3; Synonyms=OR1E3P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-317.
RX PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT "Sequence, structure, and evolution of a complete human olfactory receptor
RT gene cluster.";
RL Genomics 63:227-245(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=8004088; DOI=10.1093/hmg/3.2.229;
RA Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
RA Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
RT "Olfactory receptor gene cluster on human chromosome 17: possible
RT duplication of an ancestral receptor repertoire.";
RL Hum. Mol. Genet. 3:229-235(1994).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [7]
RP POLYMORPHISM.
RX PubMed=12730696; DOI=10.1038/ng1160;
RA Menashe I., Man O., Lancet D., Gilad Y.;
RT "Different noses for different people.";
RL Nat. Genet. 34:143-144(2003).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A single nucleotide deletion at position Leu-17 in the
CC gene coding for this protein is responsible for functional diversity
CC thus producing a pseudogene.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1E3P";
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DR EMBL; AC097370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF087929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U04690; AAA18353.1; -; Genomic_DNA.
DR EMBL; AF399437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; I38482; I38482.
DR AlphaFoldDB; Q8WZA6; -.
DR SMR; Q8WZA6; -.
DR GlyCosmos; Q8WZA6; 1 site, No reported glycans.
DR GlyGen; Q8WZA6; 1 site.
DR BioMuta; HGNC:8191; -.
DR DMDM; 166215840; -.
DR MassIVE; Q8WZA6; -.
DR AGR; HGNC:8191; -.
DR GeneCards; OR1E3; -.
DR HGNC; HGNC:8191; OR1E3.
DR neXtProt; NX_Q8WZA6; -.
DR InParanoid; Q8WZA6; -.
DR PhylomeDB; Q8WZA6; -.
DR PathwayCommons; Q8WZA6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR Pharos; Q8WZA6; Tdark.
DR PRO; PR:Q8WZA6; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8WZA6; Protein.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR48001:SF130; OLFACTORY RECEPTOR 1E1-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..343
FT /note="Olfactory receptor 1E3"
FT /id="PRO_0000315943"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..107
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..141
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..195
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..242
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..310
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 332..343
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 24
FT /note="Q -> R (in Ref. 2; AF087929)"
FT /evidence="ECO:0000305"
FT CONFLICT 141..143
FT /note="CLG -> WLA (in Ref. 3; AAA18353)"
FT /evidence="ECO:0000305"
FT CONFLICT 164..165
FT /note="AR -> GS (in Ref. 3; AAA18353)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 343 AA; 38518 MW; D20294E28EF1A787 CRC64;
MMKKNQTMIS EFLLLGLPIQ PEQQNLFYAL FLAVYLTTLL GNLLVIVLIR LDSHLHMPMY
LCLSNLSFSD LCFSSVTMPK LLQNMQSQNP SIPFADCLAQ MYFHLFYGVL ESFLLVVMAY
HCYVAICFPL HYTTIMSPKC CLGLLTLSWL LTTAHATLHT LLMARLSFCA ENVIPHFFCD
TSTLLKLACS NTQVNGWVMF FMGGLILVIP FLLLIMSCAR IVSTILRVPS TGGIQKAFST
CGPHLSVVSL FYGTIIGLYL CPLTNHNTVK DTVMAVMYTG VTHMLNPFIY SLRNRDMRGN
PGQSLQHKEN FFVFKIVIVG ILPLLNLVGV VKLIMKYHSK SVA
//
