ID OR2L8_HUMAN Reviewed; 312 AA.
AC Q8NGY9; B9EIN6; Q6IF03;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 24-JAN-2024, entry version 155.
DE RecName: Full=Olfactory receptor 2L8;
DE AltName: Full=Olfactory receptor OR1-46;
GN Name=OR2L8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-294 AND LYS-301.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2L8";
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DR EMBL; AB065627; BAC05853.1; -; Genomic_DNA.
DR EMBL; BC140751; AAI40752.1; -; mRNA.
DR EMBL; BK004459; DAA04857.1; -; Genomic_DNA.
DR RefSeq; NP_001001963.1; NM_001001963.1.
DR AlphaFoldDB; Q8NGY9; -.
DR SMR; Q8NGY9; -.
DR STRING; 9606.ENSP00000485287; -.
DR GlyCosmos; Q8NGY9; 2 sites, No reported glycans.
DR GlyGen; Q8NGY9; 2 sites.
DR BioMuta; OR2L8; -.
DR DMDM; 38372791; -.
DR MassIVE; Q8NGY9; -.
DR PaxDb; 9606-ENSP00000349719; -.
DR PeptideAtlas; Q8NGY9; -.
DR Antibodypedia; 79198; 76 antibodies from 16 providers.
DR DNASU; 391190; -.
DR Ensembl; ENST00000623922.1; ENSP00000485287.1; ENSG00000279263.1.
DR GeneID; 391190; -.
DR KEGG; hsa:391190; -.
DR MANE-Select; ENST00000623922.1; ENSP00000485287.1; NM_001001963.1; NP_001001963.1.
DR UCSC; uc001idt.1; human.
DR AGR; HGNC:15014; -.
DR CTD; 391190; -.
DR GeneCards; OR2L8; -.
DR HGNC; HGNC:15014; OR2L8.
DR HPA; ENSG00000279263; Not detected.
DR neXtProt; NX_Q8NGY9; -.
DR PharmGKB; PA32189; -.
DR VEuPathDB; HostDB:ENSG00000279263; -.
DR eggNOG; ENOG502RTYI; Eukaryota.
DR GeneTree; ENSGT01090000259995; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGY9; -.
DR OMA; PEMASNY; -.
DR OrthoDB; 3784606at2759; -.
DR PhylomeDB; Q8NGY9; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NGY9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 391190; 10 hits in 630 CRISPR screens.
DR GeneWiki; OR2L8; -.
DR GenomeRNAi; 391190; -.
DR Pharos; Q8NGY9; Tdark.
DR PRO; PR:Q8NGY9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGY9; Protein.
DR Bgee; ENSG00000279263; Expressed in adrenal tissue.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR CDD; cd15421; 7tmA_OR2T-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR26453:SF632; OLFACTORY RECEPTOR 2L8; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 2L8"
FT /id="PRO_0000150489"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 196
FT /note="G -> C (in dbSNP:rs4925788)"
FT /id="VAR_059987"
FT VARIANT 202
FT /note="A -> T (in dbSNP:rs4925790)"
FT /id="VAR_059988"
FT VARIANT 217
FT /note="Y -> C (in dbSNP:rs4925583)"
FT /id="VAR_053147"
FT VARIANT 226
FT /note="H -> R (in dbSNP:rs4925792)"
FT /id="VAR_062024"
FT VARIANT 294
FT /note="K -> R (in dbSNP:rs10888282)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_059989"
FT VARIANT 301
FT /note="T -> K (in dbSNP:rs74155337)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_080452"
SQ SEQUENCE 312 AA; 35444 MW; 845325F98685A4D4 CRC64;
MENYNQTSTD FILLGLFPPS RIDLFFFILI VFIFLMALIG NLSMILLIFL DTHLHTPMYF
LLSQLSLIDL NYISTIVPKM ASDFLHGNKS ISFTGCGIQS FFFLALGGAE ALLLASMAYD
RYIAICFPLH YLIRMSKRVC VLMITGSWII GSINACAHTV YVLHIPYCRS RAINHFFCDV
PAMVTLACMD TWVYEGTVFL SATIFLVFPF IGISCSYGQV LFAVYHMKSA EGRKKAYLTC
STHLTVVTFY YAPFVYTYLR PRSLRSPTED KVLAVFYTIL TPMLNPIIYS LRNKEVMGAL
TRVSQRICSV KM
//
