ID OR4C3_HUMAN Reviewed; 302 AA.
AC Q8NH37; B2RNF2; Q6IFB3;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2003, sequence version 2.
DT 24-JAN-2024, entry version 161.
DE RecName: Full=Olfactory receptor 4C3;
DE AltName: Full=Olfactory receptor OR11-98;
GN Name=OR4C3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI36854.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI36855.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC05803.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=DAA04747.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=EAW67868.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C3";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065567; BAC05803.1; ALT_INIT; Genomic_DNA.
DR EMBL; AC023080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW67868.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC136853; AAI36854.1; ALT_INIT; mRNA.
DR EMBL; BC136854; AAI36855.1; ALT_INIT; mRNA.
DR EMBL; BK004349; DAA04747.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS31489.2; -.
DR RefSeq; NP_001004702.1; NM_001004702.1.
DR AlphaFoldDB; Q8NH37; -.
DR SMR; Q8NH37; -.
DR STRING; 9606.ENSP00000493096; -.
DR GlyCosmos; Q8NH37; 1 site, No reported glycans.
DR GlyGen; Q8NH37; 1 site.
DR iPTMnet; Q8NH37; -.
DR PhosphoSitePlus; Q8NH37; -.
DR BioMuta; OR4C3; -.
DR DMDM; 38372802; -.
DR MassIVE; Q8NH37; -.
DR PaxDb; 9606-ENSP00000321419; -.
DR ProteomicsDB; 73652; -.
DR Antibodypedia; 63155; 48 antibodies from 17 providers.
DR DNASU; 256144; -.
DR Ensembl; ENST00000319856.5; ENSP00000321419.5; ENSG00000176547.11.
DR GeneID; 256144; -.
DR KEGG; hsa:256144; -.
DR MANE-Select; ENST00000319856.5; ENSP00000321419.5; NM_001004702.2; NP_001004702.2.
DR UCSC; uc010rhv.3; human.
DR AGR; HGNC:14697; -.
DR CTD; 256144; -.
DR DisGeNET; 256144; -.
DR GeneCards; OR4C3; -.
DR HGNC; HGNC:14697; OR4C3.
DR HPA; ENSG00000176547; Not detected.
DR neXtProt; NX_Q8NH37; -.
DR PharmGKB; PA32261; -.
DR VEuPathDB; HostDB:ENSG00000176547; -.
DR eggNOG; ENOG502TK3X; Eukaryota.
DR GeneTree; ENSGT00940000163173; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NH37; -.
DR OMA; MPHNITE; -.
DR OrthoDB; 4052270at2759; -.
DR PhylomeDB; Q8NH37; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NH37; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 256144; 7 hits in 736 CRISPR screens.
DR GeneWiki; OR4C3; -.
DR GenomeRNAi; 256144; -.
DR Pharos; Q8NH37; Tdark.
DR PRO; PR:Q8NH37; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH37; Protein.
DR Bgee; ENSG00000176547; Expressed in cortex of kidney.
DR ExpressionAtlas; Q8NH37; differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR CDD; cd15939; 7tmA_OR4A-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR48002:SF40; OLFACTORY RECEPTOR 4C3; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..302
FT /note="Olfactory receptor 4C3"
FT /id="PRO_0000150529"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..302
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 302 AA; 33726 MW; 2DF2E650E040E4E1 CRC64;
MDIPQNITEF FMLGLSQNSE VQRVLFVVFL LIYVVTVCGN MLIVVTITSS PTLASPVYFF
LANLSFIDTF YSSSMAPKLI ADSLYEGRTI SYECCMAQLF GAHFLGGVEI ILLTVMAYDR
YVAICKPLHN TTIMTRHLCA MLVGVAWLGG FLHSLVQLLL VLWLPFCGPN VINHFACDLY
PLLEVACTNT YVIGLLVVAN SGLICLLNFL MLAASYIVIL YSLRSHSADG RCKALSTCGA
HFIVVALFFV PCIFTYVHPF STLPIDKNMA LFYGILTPML NPLIYTLRNE EVKNAMRKLF
TW
//
