ID OR4F5_HUMAN Reviewed; 305 AA.
AC Q8NH21; Q5VT22;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 24-JAN-2024, entry version 151.
DE RecName: Full=Olfactory receptor 4F5;
GN Name=OR4F5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4F5";
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DR EMBL; AB065592; BAC05820.1; -; Genomic_DNA.
DR EMBL; AL627309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001005484.1; NM_001005484.1.
DR AlphaFoldDB; Q8NH21; -.
DR SMR; Q8NH21; -.
DR STRING; 9606.ENSP00000334393; -.
DR iPTMnet; Q8NH21; -.
DR PhosphoSitePlus; Q8NH21; -.
DR BioMuta; OR4F5; -.
DR DMDM; 38372801; -.
DR PaxDb; 9606-ENSP00000334393; -.
DR PeptideAtlas; Q8NH21; -.
DR Antibodypedia; 58296; 63 antibodies from 16 providers.
DR DNASU; 79501; -.
DR GeneID; 79501; -.
DR KEGG; hsa:79501; -.
DR UCSC; uc001aal.1; human.
DR AGR; HGNC:14825; -.
DR CTD; 79501; -.
DR GeneCards; OR4F5; -.
DR HGNC; HGNC:14825; OR4F5.
DR neXtProt; NX_Q8NH21; -.
DR PharmGKB; PA32291; -.
DR VEuPathDB; HostDB:ENSG00000186092; -.
DR eggNOG; ENOG502SKZV; Eukaryota.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NH21; -.
DR OMA; VISIKGC; -.
DR OrthoDB; 4629521at2759; -.
DR PhylomeDB; Q8NH21; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NH21; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 79501; 16 hits in 636 CRISPR screens.
DR ChiTaRS; OR4F5; human.
DR GenomeRNAi; 79501; -.
DR Pharos; Q8NH21; Tdark.
DR PRO; PR:Q8NH21; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NH21; Protein.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR CDD; cd15226; 7tmA_OR4-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR48002:SF51; OLFACTORY RECEPTOR 4F17-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..305
FT /note="Olfactory receptor 4F5"
FT /id="PRO_0000150547"
FT TOPO_DOM 1..18
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..72
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..113
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..151
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..212
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..251
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..282
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 90..182
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 305 AA; 34330 MW; 70E99D068AB2DD59 CRC64;
MVTEFIFLGL SDSQELQTFL FMLFFVFYGG IVFGNLLIVI TVVSDSHLHS PMYFLLANLS
LIDLSLSSVT APKMITDFFS QRKVISFKGC LVQIFLLHFF GGSEMVILIA MGFDRYIAIC
KPLHYTTIMC GNACVGIMAV TWGIGFLHSV SQLAFAVHLL FCGPNEVDSF YCDLPRVIKL
ACTDTYRLDI MVIANSGVLT VCSFVLLIIS YTIILMTIQH RPLDKSSKAL STLTAHITVV
LLFFGPCVFI YAWPFPIKSL DKFLAVFYSV ITPLLNPIIY TLRNKDMKTA IRQLRKWDAH
SSVKF
//
