ID OR6B3_HUMAN Reviewed; 331 AA.
AC Q8NGW1; Q6IFH3;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 157.
DE RecName: Full=Olfactory receptor 6B3;
DE AltName: Full=Olfactory receptor OR2-2;
GN Name=OR6B3; Synonyms=OR6B3P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04687.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6B3";
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DR EMBL; AB065662; BAC05888.1; -; Genomic_DNA.
DR EMBL; BK004289; DAA04687.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS42837.1; -.
DR RefSeq; NP_775486.1; NM_173351.1.
DR AlphaFoldDB; Q8NGW1; -.
DR SMR; Q8NGW1; -.
DR BioGRID; 127316; 3.
DR IntAct; Q8NGW1; 1.
DR STRING; 9606.ENSP00000493035; -.
DR GlyCosmos; Q8NGW1; 1 site, No reported glycans.
DR GlyGen; Q8NGW1; 1 site.
DR PhosphoSitePlus; Q8NGW1; -.
DR BioMuta; OR6B3; -.
DR DMDM; 38258179; -.
DR MassIVE; Q8NGW1; -.
DR PaxDb; 9606-ENSP00000322435; -.
DR PeptideAtlas; Q8NGW1; -.
DR Antibodypedia; 66158; 47 antibodies from 16 providers.
DR DNASU; 150681; -.
DR Ensembl; ENST00000641019.2; ENSP00000493035.1; ENSG00000178586.7.
DR GeneID; 150681; -.
DR KEGG; hsa:150681; -.
DR MANE-Select; ENST00000641019.2; ENSP00000493035.1; NM_173351.2; NP_775486.1.
DR UCSC; uc010zoe.2; human.
DR AGR; HGNC:15042; -.
DR CTD; 150681; -.
DR GeneCards; OR6B3; -.
DR HGNC; HGNC:15042; OR6B3.
DR HPA; ENSG00000178586; Tissue enriched (retina).
DR neXtProt; NX_Q8NGW1; -.
DR OpenTargets; ENSG00000178586; -.
DR PharmGKB; PA32578; -.
DR VEuPathDB; HostDB:ENSG00000178586; -.
DR eggNOG; ENOG502SJJZ; Eukaryota.
DR GeneTree; ENSGT01090000260045; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGW1; -.
DR OMA; WANTSLH; -.
DR OrthoDB; 4639121at2759; -.
DR PhylomeDB; Q8NGW1; -.
DR TreeFam; TF337475; -.
DR PathwayCommons; Q8NGW1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGW1; -.
DR BioGRID-ORCS; 150681; 8 hits in 742 CRISPR screens.
DR GeneWiki; OR6B3; -.
DR GenomeRNAi; 150681; -.
DR Pharos; Q8NGW1; Tdark.
DR PRO; PR:Q8NGW1; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8NGW1; Protein.
DR Bgee; ENSG00000178586; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 31 other cell types or tissues.
DR ExpressionAtlas; Q8NGW1; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR CDD; cd15224; 7tmA_OR6B-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26452; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR26452:SF222; OLFACTORY RECEPTOR 6B2-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..331
FT /note="Olfactory receptor 6B3"
FT /id="PRO_0000150622"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 234
FT /note="C -> Y (in dbSNP:rs12465491)"
FT /id="VAR_062049"
SQ SEQUENCE 331 AA; 37232 MW; 88E9369D2BAB6244 CRC64;
MSGENVTRVG TFILVGFPTA PGLQYLLFLL FLLTYLFVLV ENLAIILTVW SSTSLHRPMY
YFLSSMSFLE IWYVSDITPK MLEGFLLQQK RISFVGCMTQ LYFFSSLVCT ECVLLASMAY
DRYVAICHPL RYHVLVTPGL CLQLVGFSFV SGFTISMIKV CFISSVTFCG SNVLNHFFCD
ISPILKLACT DFSTAELVDF ILAFIILVFP LLATMLSYAH ITLAVLRIPS ATGCWRAFFT
CASHLTVVTV FYTALLFMYV RPQAIDSRSS NKLISVLYTV ITPILNPLIY CLRNKEFKNA
LKKAFGLTSC AVEGRLSSLL ELHLQIHSQP L
//
