ID OR7AA_HUMAN Reviewed; 309 AA.
AC O76100; Q6IFP0; Q96R97;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 24-JAN-2024, entry version 172.
DE RecName: Full=Olfactory receptor 7A10;
DE AltName: Full=OST027;
DE AltName: Full=Olfactory receptor OR19-18;
GN Name=OR7A10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Sperm;
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7A10";
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DR EMBL; AC005255; AAC25627.1; -; Genomic_DNA.
DR EMBL; AF399542; AAK95027.1; -; Genomic_DNA.
DR EMBL; BK004222; DAA04620.1; -; Genomic_DNA.
DR CCDS; CCDS32936.1; -.
DR RefSeq; NP_001005190.1; NM_001005190.1.
DR AlphaFoldDB; O76100; -.
DR SMR; O76100; -.
DR BioGRID; 133724; 2.
DR IntAct; O76100; 1.
DR STRING; 9606.ENSP00000493055; -.
DR GlyCosmos; O76100; 1 site, No reported glycans.
DR GlyGen; O76100; 1 site.
DR BioMuta; OR7A10; -.
DR MassIVE; O76100; -.
DR PaxDb; 9606-ENSP00000248058; -.
DR PeptideAtlas; O76100; -.
DR TopDownProteomics; O76100; -.
DR Antibodypedia; 59282; 48 antibodies from 14 providers.
DR DNASU; 390892; -.
DR Ensembl; ENST00000641129.1; ENSP00000493055.1; ENSG00000127515.3.
DR GeneID; 390892; -.
DR KEGG; hsa:390892; -.
DR MANE-Select; ENST00000641129.1; ENSP00000493055.1; NM_001005190.2; NP_001005190.1.
DR UCSC; uc002mzx.1; human.
DR AGR; HGNC:8356; -.
DR CTD; 390892; -.
DR GeneCards; OR7A10; -.
DR HGNC; HGNC:8356; OR7A10.
DR HPA; ENSG00000127515; Not detected.
DR neXtProt; NX_O76100; -.
DR PharmGKB; PA32611; -.
DR VEuPathDB; HostDB:ENSG00000127515; -.
DR eggNOG; ENOG502RTYS; Eukaryota.
DR GeneTree; ENSGT00940000153523; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; O76100; -.
DR OMA; PLHYRAM; -.
DR OrthoDB; 5401587at2759; -.
DR PhylomeDB; O76100; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; O76100; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; O76100; -.
DR BioGRID-ORCS; 390892; 205 hits in 683 CRISPR screens.
DR ChiTaRS; OR7A10; human.
DR GeneWiki; OR7A10; -.
DR GenomeRNAi; 390892; -.
DR Pharos; O76100; Tdark.
DR PRO; PR:O76100; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O76100; Protein.
DR ExpressionAtlas; O76100; baseline and differential.
DR Genevisible; O76100; HS.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd15234; 7tmA_OR7-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR48001:SF112; OLFACTORY RECEPTOR 7A10; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 7A10"
FT /id="PRO_0000150644"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 151
FT /note="M -> T (in dbSNP:rs12972670)"
FT /id="VAR_053225"
FT VARIANT 183
FT /note="Q -> E (in dbSNP:rs9305052)"
FT /id="VAR_034254"
FT VARIANT 225
FT /note="I -> L (in dbSNP:rs11880955)"
FT /id="VAR_053226"
FT VARIANT 273
FT /note="A -> T (in dbSNP:rs10221530)"
FT /id="VAR_053227"
FT CONFLICT 70
FT /note="D -> G (in Ref. 2; AAK95027)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 309 AA; 34406 MW; 8761B3C97FE3ADB1 CRC64;
MKSWNNTIIL EFLLLGISEE PELQAFLFGL FLSMYLVTVL GNLLIILATI SDSHLHTPMY
FFLSNLSFVD ICFVSTTVPK MLVNIQTHNK VITYAGCITQ MCFFLLFVGL DNFLLTVMAY
DRFVAICHPL HYMVIMNPQL CGLLVLASWI MSVLNSMLQS LMVLPLPFCT HMEIPHFFCE
INQVVHLACS DTFLNDIVMY FAVALLGGGP LTGILYSYSK IVSSIRAISS AQGKYKAFST
CASHLSVVSL FYGTCLGVYL SSAATHNSHT GAAASVMYTV VTPMLNPFIY SLRNKHIKGA
MKTFFRGKQ
//
