ID IFN21_HUMAN Reviewed; 189 AA.
AC P01568; Q14608; Q5VWD1; Q7M4Q4;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2002, sequence version 2.
DT 01-MAY-2013, entry version 134.
DE RecName: Full=Interferon alpha-21;
DE Short=IFN-alpha-21;
DE AltName: Full=Interferon alpha-F;
DE Short=LeIF F;
DE Flags: Precursor;
GN Name=IFNA21;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT MET-119.
RX PubMed=6163083; DOI=10.1038/290020a0;
RA Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M.,
RA McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.;
RT "The structure of eight distinct cloned human leukocyte interferon
RT cDNAs.";
RL Nature 290:20-26(1981).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Gren E.Y., Berzin V.M., Tsimanis A.Y., Apsalon U.R., Vishnevskii Y.I.,
RA Yansone I.V., Dishler A.V., Pudova N.V., Smorodintsev A.A.,
RA Iovlev V.I., Stepanov A.N., Feldmane G.Y., Meldrais Y.A., Lozha V.P.,
RA Kavsan V.M., Efimov V.A., Sverdlov E.D.;
RT "A new type of leukocytic interferon.";
RL Dokl. Biochem. 269:91-95(1983).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=6548765;
RA Gren E., Berzin V.M., Jansone I., Tsimanis A., Vishnevsky Y.,
RA Apsalons U.;
RT "Novel human leukocyte interferon subtype and structural comparison of
RT alpha interferon genes.";
RL J. Interferon Res. 4:609-617(1984).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA Rogers J., Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 24-189.
RC TISSUE=Lymphoblast;
RX PubMed=3803589; DOI=10.1016/0014-5793(87)81278-4;
RA Ohara O., Teraoka H.;
RT "Anomalous behavior of human leukocyte interferon subtypes on
RT polyacrylamide gel electrophoresis in the presence of dodecyl
RT sulfate.";
RL FEBS Lett. 211:78-82(1987).
RN [8]
RP PROTEIN SEQUENCE OF 24-62, AND FUNCTION.
RX PubMed=1634550;
RA Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C.,
RA Nguyen N.Y., Hu R.-Q.;
RT "Purification and characterization of multiple components of human
RT lymphoblastoid interferon-alpha.";
RL J. Biol. Chem. 267:15210-15216(1992).
RN [9]
RP PROTEIN SEQUENCE OF 24-58.
RX PubMed=9425112;
RA Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.;
RT "Identification of nine interferon-alpha subtypes produced by Sendai
RT virus-induced human peripheral blood leucocytes.";
RL Biochem. J. 329:295-302(1998).
RN [10]
RP ABSENCE OF POLYMORPHISM.
RX PubMed=8910771; DOI=10.1089/jir.1996.16.853;
RA Hussain M., Gill D.S., Liao M.-J.;
RT "Identification of interferon-alpha 7, -alpha 14, and -alpha 21
RT variants in the genome of a large human population.";
RL J. Interferon Cytokine Res. 16:853-859(1996).
CC -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral
CC activities. Interferon stimulates the production of two enzymes: a
CC protein kinase and an oligoadenylate synthetase.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA36041.1; Type=Erroneous initiation;
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DR EMBL; V00540; CAA23801.1; -; mRNA.
DR EMBL; M12350; AAA52718.1; -; mRNA.
DR EMBL; X00145; CAA24980.1; -; mRNA.
DR EMBL; M28586; AAA36041.1; ALT_INIT; mRNA.
DR EMBL; AL390882; CAH70157.1; -; Genomic_DNA.
DR EMBL; CH471071; EAW58623.1; -; Genomic_DNA.
DR EMBL; BC069329; AAH69329.1; -; mRNA.
DR EMBL; BC069372; AAH69372.1; -; mRNA.
DR EMBL; BC069408; AAH69408.1; -; mRNA.
DR EMBL; BC096699; AAH96699.1; -; mRNA.
DR EMBL; BC101638; AAI01639.1; -; mRNA.
DR EMBL; BC101640; AAI01641.1; -; mRNA.
DR IPI; IPI00307189; -.
DR PIR; A01832; IVHUF.
DR PIR; D42753; D42753.
DR PIR; E25843; E25843.
DR PIR; I56313; I56313.
DR PIR; I84464; I84464.
DR RefSeq; NP_002166.2; NM_002175.2.
DR UniGene; Hs.113211; -.
DR ProteinModelPortal; P01568; -.
DR STRING; 9606.ENSP00000369574; -.
DR DMDM; 20178289; -.
DR PaxDb; P01568; -.
DR DNASU; 3452; -.
DR Ensembl; ENST00000380225; ENSP00000369574; ENSG00000137080.
DR GeneID; 3452; -.
DR KEGG; hsa:3452; -.
DR UCSC; uc003zom.2; human.
DR CTD; 3452; -.
DR GeneCards; GC09M021165; -.
DR HGNC; HGNC:5424; IFNA21.
DR HPA; HPA047557; -.
DR MIM; 147584; gene.
DR neXtProt; NX_P01568; -.
DR PharmGKB; PA29663; -.
DR eggNOG; NOG119628; -.
DR HOGENOM; HOG000230500; -.
DR HOVERGEN; HBG052086; -.
DR InParanoid; P01568; -.
DR KO; K05414; -.
DR OMA; MTQQIFN; -.
DR OrthoDB; EOG4DV5P6; -.
DR PhylomeDB; P01568; -.
DR Pathway_Interaction_DB; cd8tcrdownstreampathway; Downstream signaling in naive CD8+ T cells.
DR Reactome; REACT_604; Hemostasis.
DR Reactome; REACT_6900; Immune System.
DR GenomeRNAi; 3452; -.
DR NextBio; 13600; -.
DR ArrayExpress; P01568; -.
DR Bgee; P01568; -.
DR CleanEx; HS_IFNA21; -.
DR Genevestigator; P01568; -.
DR GermOnline; ENSG00000137080; Homo sapiens.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005126; F:cytokine receptor binding; TAS:ProtInc.
DR GO; GO:0007596; P:blood coagulation; TAS:Reactome.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome.
DR GO; GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR012351; 4_helix_cytokine_core.
DR InterPro; IPR015589; Interferon_alpha.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR PANTHER; PTHR11691:SF9; PTHR11691:SF9; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; 4_helix_cytokine; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 1: Evidence at protein level;
KW Antiviral defense; Complete proteome; Cytokine;
KW Direct protein sequencing; Disulfide bond; Polymorphism;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 23
FT CHAIN 24 189 Interferon alpha-21.
FT /FTId=PRO_0000016370.
FT DISULFID 24 122 By similarity.
FT DISULFID 52 162 By similarity.
FT VARIANT 119 119 L -> M (in dbSNP:rs1053885).
FT /FTId=VAR_055325.
FT VARIANT 179 179 K -> E (in dbSNP:rs3750478).
FT /FTId=VAR_049638.
FT CONFLICT 60 60 G -> E (in Ref. 8; AA sequence).
SQ SEQUENCE 189 AA; 21741 MW; F0B6C9C392905802 CRC64;
MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF SCLKDRHDFG
FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW EQSLLEKFST ELNQQLNDLE
ACVIQEVGVE ETPLMNVDSI LAVKKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSFSLSKI
FQERLRRKE
//
