ID COX6C_BOVIN Reviewed; 74 AA.
AC P04038; A0JNM4;
DT 01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 2.
DT 03-APR-2013, entry version 104.
DE RecName: Full=Cytochrome c oxidase subunit 6C;
DE AltName: Full=Cytochrome c oxidase polypeptide VIc;
DE AltName: Full=Cytochrome c oxidase subunit STA;
GN Name=COX6C;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC Pecora; Bovidae; Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal medulla;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 2-74.
RC TISSUE=Liver;
RX PubMed=2988583;
RA Erdweg M., Buse G.;
RT "Studies on cytochrome c oxidase, XI. The amino-acid sequence of
RT bovine heart polypeptide VIc.";
RL Biol. Chem. Hoppe-Seyler 366:257-263(1985).
RN [3]
RP PROTEIN SEQUENCE OF 2-21.
RC TISSUE=Liver;
RX PubMed=2844245; DOI=10.1021/bi00413a048;
RA Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.;
RT "Tissue-specific differences between heart and liver cytochrome c
RT oxidase.";
RL Biochemistry 27:4909-4914(1988).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
RX PubMed=8638158; DOI=10.1126/science.272.5265.1136;
RA Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H.,
RA Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.;
RT "The whole structure of the 13-subunit oxidized cytochrome c oxidase
RT at 2.8 A.";
RL Science 272:1136-1144(1996).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
RC TISSUE=Heart;
RX PubMed=10089392; DOI=10.1107/S0907444998006362;
RA Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T.,
RA Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.;
RT "Structure analysis of bovine heart cytochrome c oxidase at 2.8 A
RT resolution.";
RL Acta Crystallogr. D 55:31-45(1999).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
RC TISSUE=Heart;
RX PubMed=10771420; DOI=10.1107/S0907444900002213;
RA Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T.,
RA Shinzawa-Itoh K., Nakashima R., Yoshikawa S.;
RT "X-ray structure of azide-bound fully oxidized cytochrome c oxidase
RT from bovine heart at 2.9 A resolution.";
RL Acta Crystallogr. D 56:529-535(2000).
CC -!- FUNCTION: This protein is one of the nuclear-coded polypeptide
CC chains of cytochrome c oxidase, the terminal oxidase in
CC mitochondrial electron transport.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 6c family.
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DR EMBL; BC126788; AAI26789.1; -; mRNA.
DR IPI; IPI00707430; -.
DR PIR; A00496; OGBO6C.
DR RefSeq; NP_001231040.1; NM_001244111.1.
DR UniGene; Bt.28261; -.
DR PDB; 1OCC; X-ray; 2.80 A; I/V=2-74.
DR PDB; 1OCO; X-ray; 2.80 A; I/V=2-73.
DR PDB; 1OCR; X-ray; 2.35 A; I/V=2-73.
DR PDB; 1OCZ; X-ray; 2.90 A; I/V=2-73.
DR PDB; 1V54; X-ray; 1.80 A; I/V=2-73.
DR PDB; 1V55; X-ray; 1.90 A; I/V=2-73.
DR PDB; 2DYR; X-ray; 1.80 A; I/V=2-73.
DR PDB; 2DYS; X-ray; 2.20 A; I/V=2-74.
DR PDB; 2EIJ; X-ray; 1.90 A; I/V=2-73.
DR PDB; 2EIK; X-ray; 2.10 A; I/V=2-73.
DR PDB; 2EIL; X-ray; 2.10 A; I/V=2-73.
DR PDB; 2EIM; X-ray; 2.60 A; I/V=2-73.
DR PDB; 2EIN; X-ray; 2.70 A; I/V=2-73.
DR PDB; 2OCC; X-ray; 2.30 A; I/V=2-73.
DR PDB; 2Y69; X-ray; 1.95 A; I/V=1-74.
DR PDB; 2YBB; EM; 19.00 A; T=2-74.
DR PDB; 2ZXW; X-ray; 2.50 A; I/V=2-74.
DR PDB; 3ABK; X-ray; 2.00 A; I/V=2-74.
DR PDB; 3ABL; X-ray; 2.10 A; I/V=2-74.
DR PDB; 3ABM; X-ray; 1.95 A; I/V=2-74.
DR PDB; 3AG1; X-ray; 2.20 A; I/V=2-74.
DR PDB; 3AG2; X-ray; 1.80 A; I/V=2-74.
DR PDB; 3AG3; X-ray; 1.80 A; I/V=2-74.
DR PDB; 3AG4; X-ray; 2.05 A; I/V=2-74.
DR PDB; 3ASN; X-ray; 3.00 A; I/V=2-74.
DR PDB; 3ASO; X-ray; 2.30 A; I/V=2-74.
DR PDBsum; 1OCC; -.
DR PDBsum; 1OCO; -.
DR PDBsum; 1OCR; -.
DR PDBsum; 1OCZ; -.
DR PDBsum; 1V54; -.
DR PDBsum; 1V55; -.
DR PDBsum; 2DYR; -.
DR PDBsum; 2DYS; -.
DR PDBsum; 2EIJ; -.
DR PDBsum; 2EIK; -.
DR PDBsum; 2EIL; -.
DR PDBsum; 2EIM; -.
DR PDBsum; 2EIN; -.
DR PDBsum; 2OCC; -.
DR PDBsum; 2Y69; -.
DR PDBsum; 2YBB; -.
DR PDBsum; 2ZXW; -.
DR PDBsum; 3ABK; -.
DR PDBsum; 3ABL; -.
DR PDBsum; 3ABM; -.
DR PDBsum; 3AG1; -.
DR PDBsum; 3AG2; -.
DR PDBsum; 3AG3; -.
DR PDBsum; 3AG4; -.
DR PDBsum; 3ASN; -.
DR PDBsum; 3ASO; -.
DR ProteinModelPortal; P04038; -.
DR SMR; P04038; 2-74.
DR IntAct; P04038; 2.
DR PRIDE; P04038; -.
DR Ensembl; ENSBTAT00000018778; ENSBTAP00000018778; ENSBTAG00000014130.
DR GeneID; 614700; -.
DR KEGG; bta:614700; -.
DR eggNOG; NOG86594; -.
DR GeneTree; ENSGT00390000004573; -.
DR HOGENOM; HOG000039249; -.
DR HOVERGEN; HBG051091; -.
DR InParanoid; P04038; -.
DR KO; K02268; -.
DR OMA; ADNERMT; -.
DR OrthoDB; EOG42JNT3; -.
DR EvolutionaryTrace; P04038; -.
DR NextBio; 20899236; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR Gene3D; 4.10.93.10; -; 1.
DR InterPro; IPR004204; Cyt_c_oxidase_su6c.
DR PANTHER; PTHR12916; PTHR12916; 1.
DR Pfam; PF02937; COX6C; 1.
DR ProDom; PD015032; Cyt_c_oxidase_su6c; 1.
DR SUPFAM; SSF81415; COX6C; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Complete proteome;
KW Direct protein sequencing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 74 Cytochrome c oxidase subunit 6C.
FT /FTId=PRO_0000191301.
FT TOPO_DOM 2 12 Mitochondrial matrix.
FT TRANSMEM 13 53 Helical.
FT TOPO_DOM 54 74 Mitochondrial intermembrane.
FT MOD_RES 59 59 N6-acetyllysine (By similarity).
FT HELIX 13 39
FT HELIX 41 53
FT HELIX 57 66
SQ SEQUENCE 74 AA; 8610 MW; E063BDB1B7AE9E4C CRC64;
MSTALAKPQM RGLLARRLRF HIVGAFMVSL GFATFYKFAV AEKRKKAYAD FYRNYDSMKD
FEEMRKAGIF QSAK
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